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At least 19 recordsLinked to original sources

PubMed1991

[Pre-project evaluation of a government based international family planning co-operative project--from a survey at project site in Colombia].

A government based international co-operative project for family planning was formulated between Japan and Colombia. A baseline survey was carried out at the project site in northern Colombia as a pre-project evaluation. A total of 330 households were sampled and the housewives were interviewed concerning family planning. Births averted by the existing government program were estimated employing Bongaarts prevalence model. In addition, background and conditions leading to inability to receive family planning services were analyzed. The results showed that of total births averted, government programs contributed around 50% reflecting the apparent insufficiency of the services in reaching women in their forties and teens. Educational attainment and place of birth on the part of the woman, household income, discussion of number of children desired between husband and wife were among the most important factors for women wishing contraception practice but not being able to receive family planning services. Based on this analysis, a service program was mapped out to meet the need of residents of the project site.

Adolescent↗

PubMed2000

Conditionally immortal neuroepithelial stem cell grafts restore spatial learning in rats with lesions at the source of cholinergic forebrain projections cholinergic forebrain projections Conditionally immortal neuroepithelial stem cell grafts restore spatial leaming in rats with lesions at the source of cholinergic forebrain projections.

Purpose: Loss of cholinergic projections from the basal forebrain (BF) to the cortex and from the medial septal area (MSA) to tbe hippocampus is a reliable correlate of cognitive deficits in aging and Alzheimer's disease (AD). We assessed the capacity of grafts of the conditionally immortal MHP36 clonal stem cell line to improve spatial learning in rats showing profound deficits after lesions to these projections. Methods: Rats were lesioned by infusions of S-AMPA unilaterally into BF or bilaterally into both BF and MSA. MHP36 cells were implanted ipsilaterally in cortex or basal forebrain two weeks after unilateral BF lesions, and in cortex and hippocampus bilaterally six months after bilateral BF-MSA lesions. Intact and lesion-only controls received vehicle. Six weeks later rats were assessed in spatial learning and memory tasks in the water maze, and then perfused for identification of grafted cells by beta-galactosidase immunohistocheniistry. Results: Lesioned rats with MHP36 grafts, whether implanted two weeks or six months after lesioning, learned to find a submerged platform in the water maze as rapidly as intact controls, and showed a strong preference for the platform quadrant on probe trials, whereas lesioned controls were impaired in all measures. Grafted cells of both neuronal and glial morphologies, migrated away from cortical implantation sites in BF Lesioned rats to the striatum, thalamus and basal forebrain lesion area. Cells implanted in basal forebrain showed a similar distribution. In rats with bilateral BF-MSA lesions, grafts implanted in the hippocampus migrated widely through all layers but cortical grafts largely escaped up the needle tract into the meninges. Conclusions: Although MHP36 grafts were functionally effective in both lesion models, the site and age of lesions and site of implantation influenced the pattern of engraftment. This flexibility encourages the development of conditionally immortal human stem cell lines with similar capacities for functional repair of variable neuronal degeneration in AD or aging.

Journal Article↗

PubMed1997

Competition among the axonal projections of an identified neuron contributes to the retraction of some of those projections.

AP neurons in the embryonic leech CNS extend lateral projections to peripheral targets through the ganglionic nerve roots and longitudinal projections toward neighboring ganglia through the connective nerves. The lateral projections grow extensively in the periphery; in contrast, the longitudinal projections achieve relatively little growth and eventually retract, the majority having essentially disappeared by the end of embryogenesis. Cutting both nerve roots, which eliminates both lateral projections, however, induces the longitudinal projections of the AP neuron to begin to grow rapidly toward adjacent ganglia within 14 hr after the axotomy. By using a laser microbeam to cut just the lateral projections of the AP cells, we further show that it is indeed the loss of its lateral projections, and not a secondary response to the cutting of other components of the root nerves, that induces the longitudinal projections of the AP cell to grow extensively. In addition, we report that reducing the outgrowth of the lateral projections by: (1) cutting only one lateral projection, or (2) ablating pioneer neurons required by the AP neuron to establish its peripheral arbor, also results in a significant increase in the growth of the longitudinal projections. Finally, we demonstrate that increasing the outgrowth of the longitudinal projections by ablating the AP cells in adjacent ganglia results in a significant reduction in the outgrowth of the lateral projections. Taken together, these results indicate, first, that the longitudinal and lateral projections usually grow at the expense of each other, and second, that normally the extensive outgrowth of its lateral projections is a necessary condition for a developing AP neuron to retract its longitudinal projections.

Animals↗

PubMed2002

Evaluation of the Quality Assurance Project and BASICS Joint Project in Niger.

OBJECTIVE: The 1998 evaluation sought to assess the Quality Assurance Project (QAP) in Niger since 1993 and the degree of quality assurance institutionalization in the Tahoua Department, and to summarize lessons from introducing the Integrated Management of Childhood Illness (IMCI) guidelines in a quality management (QM) environment. DESIGN: This evaluation collected data from interviews with staff and managers, from focus groups conducted in the communities, and from medical records. The data were then compared with three sources of evaluation criteria. A pre-project assessment provided a baseline across certain impact indicators for tracking progress. Other measures were derived from the objectives and indicators from the QAP/Tahoua project plan, the joint QAP/BASICS (Basic Support for Institutionalizing Child Survival Project) project plan, and from an additional US Agency for International Development (USAID) objective that the joint project be a model for West Africa. SETTING: The evaluation took place in the two departments of Niger in which the joint project was carried out: Tahoua and Dosso. The QA Project launched a pilot program in Niger in 1993 to strengthen newly decentralized regional and district management, and to improve the quality of primary health care in Tahoua. The principal QA Project approach was QM. The BASICS Project became active in Niger in 1995, helping to improve child health services. In 1997, the projects merged in Niger to form the joint QAP/BASICS Project. The Ministry of Public Health (MPH) planned to implement IMCI in 1998, and wished to determine whether QM facilitated the introduction of IMCI. RESULTS: The evaluation team found that QM had been effectively implemented in Tahoua and that there were related improvements in health program indicators. The team also found that the joint project had met most of its objectives and that QM facilitated the introduction of IMCI. A follow-up evaluation 2 years later found continued practice of QM by Nigerien health care providers. CONCLUSION: Several factors contributed to the success of the Tahoua QA program and the joint project: teamwork, focus on patients, clarity of roles through standards, and synergy between the QA Project and the BASICS Project.

Child Health Services↗

PubMed1999

Helminth genome analysis: the current status of the filarial and schistosome genome projects. Filarial Genome Project. Schistosome Genome Project.

Genome projects for the parasitic helminths Brugia malayi (a representative filarial nematode) and Schistosoma were initiated in 1995 by the World Health Organization with the ultimate objectives of identifying new vaccine candidates and drug targets and of developing low resolution genome maps. Because no genetic maps are available, and very few genes have been characterized from either parasite group, the first goal of both Initiatives has been to catalogue new genes for future placement on chromosome and physical maps. These genes have been identified by the expressed sequence tag (EST) approach, utilising cDNA libraries constructed from diverse life cycle stages. To date, the Initiatives have deposited over 16,000 Brugia ESTs and nearly 8000 Schistosoma ESTs in Genbank's dbEST database, corresponding to 6000 and over 3600 genes respectively (33% of Brugia's estimated gene compliment, 18-24% of that of Schistosoma). Large fragment, genomic libraries have been constructed in BAC and YAC vectors for studies of genomic organization and for physical and chromosome mapping, and public, hypertext genomic databases have been established to facilitate data access. We present a summary of progress within the helminth genome initiatives and give several examples of important gene discoveries and future applications of these data.

Animals↗

PubMed2004

[Processes and strategies for developing public health nurse directed community health projects in municipalities of Japan--focusing on setting agendas and making project alternatives].

PURPOSE: The purpose of this study was to explore processes and strategies for developing community health projects directed by public health nurses (PHNs) in municipalities of Japan. METHOD: Yin's case study design was adopted into the 5-step Policy Making Process Model as the theoretical framework. The first two steps involving agenda setting and project planning were the focus of this study. PHNs who had developed new community health projects in municipalities were interviewed as study participants. In order to maintain the quality of projects at a certain level, only these approved officially by municipalities with a program and budget were selected. RESULTS: Common strategies emerged for developing community health projects in the cases presented by the 5 PHNs. Out of 891 codes, twenty-six sub-categories were identified and integrated into 9 categories. When categories were analyzed in a time series, the following common processes were found: integration of related data, identification of the health problems in the community and recognition of project needs (Phase 1); refining the concept and characteristics of the project plan (Phase 2); and assuring that resources were available for the optimal implementation of the project by consolidating ideas (Phase 3). In Phase 1, PHNs integrated the information about previous experimental cases or social circumstances to identify community health problems needing solution. PHNs' thoughts were given to problems of existing projects and daily practices were grouped to make comprehensive plans for improvement. In Phase 2, PHNs discussed ideas for the project plans and considered resources and strategies that were necessary for putting new projects into place. In Phase 3, PHNs were attentive to the factors reviewed in Phase 2, kept account of necessary resources, and made certain of timing for immediate implementation of plans. The dual roles of PHNs, both as nurses and public servants, helped to clarify and solve the community health problems. CONCLUSION: Common strategies of developing programs were explored; "Identifying the community health problems through analyzing the causes of difficult cases," "Recognizing the necessity of coverall-projects which will improve the existing projects," "Understanding the awareness of those involved and discuss ideas for the project plan." The findings have based solely on the experiences of PHNs, they can provide suggestions that are keys to efficient development of new projects.

Cities↗

PubMed1987

Organization of subcortical pathways for sensory projections to the limbic cortex. I. Subcortical projections to the medial limbic cortex in the rat.

Subcortical afferent projections to the medial limbic cortex were examined in the rat by the use of retrograde axonal transport of horseradish peroxidase. Small iontophoretic injections of horseradish peroxidase were placed at various locations within the dorsal and ventral cingulate areas, the dorsal agranular and ventral granular divisions of the retrosplenial cortex and the presubiculum. Somata of afferent neurons in the thalamus and basal forebrain were identified by retrograde labeling. Each of the anterior thalamic nuclei was found to project to several limbic cortical areas, although not with equal density. The anterior dorsal nucleus projects primarily to the presubiculum and ventral retrosplenial cortex; the anterior ventral nucleus projects to the retrosplenial cortex and the presubiculum with apparently similar densities; and the anterior medial nucleus projects primarily to the cingulate areas. The projections from the lateral dorsal nucleus to these limbic cortical areas are organized in a loose topographic fashion. The projection to the presubiculum originates in the most dorsal portion of the lateral dorsal nucleus. The projection to the ventral retrosplenial cortex originates in rostral and medial portions of the nucleus, whereas afferents to the dorsal retrosplenial cortex originate in caudal portions of the lateral dorsal nucleus. The projection to the cingulate originates in the ventral portion of the lateral dorsal nucleus. Other projections from the thalamus originate in the intralaminar and midline nuclei, including the central lateral, central dorsal, central medial, paracentral, reuniens, and paraventricular nuclei, and the ventral medial and ventral anterior nuclei. In addition, projections to the medial limbic cortex from the basal forebrain originate in cells of the nucleus of the diagonal band. Projections to the presubiculum also originate in the medial septum. These results are discussed in regard to convergence of sensory and nonsensory information projecting to the limbic cortex and the types of visual and other sensory information that may be relayed to the limbic cortex by these projections.

Afferent Pathways↗

PubMed1985

Development of the ipsilateral retinothalamic projection in the frog Xenopus laevis. II. Ingrowth of optic nerve fibers and production of ipsilaterally projecting retinal ganglion cells.

We have studied the development of the ipsilateral retinothalamic projection in the frog Xenopus laevis by analyzing patterns of histochemical reaction product resulting from anterograde transport of horseradish peroxidase (HRP) applied to cut optic nerves in animals of various ages. We have also determined the stages during which ipsilaterally projecting ganglion cells are born using a combination of [3H] thymidine autoradiography and retrograde marking of ganglion cells following injection of HRP into the thalamus. Projections to ipsilateral thalamic terminal zones were first detectable beginning at about larval stage 54. There was a clear asynchrony in innervation, with projections to some terminal zones appearing before projections to others; projections to all terminal zones were present by late metamorphic stages. Within individual terminal zones there were progressive increases in the density of the projections as well as changes in their distribution. By these criteria, development of the ipsilateral projection was not complete at the end of metamorphosis but continued for some months thereafter. Our birth dating studies show that ipsilaterally projecting cells are produced relatively late in development and that, like the development of the projection, the production of ipsilaterally projecting ganglion cells continues postmetamorphically. The vast majority of ipsilaterally projecting cells are born over a period beginning at stage 54/55, when the projection first appears. This stage is significant, since it is at approximately this time that thyroxine-dependent metamorphic events begin. In the following paper (Hoskins, S.G., and P. Grobstein (1985) J. Neurosci. 5: 930-940) we report studies on the involvement of thyroxine in the development of the ipsilateral retinothalamic projection.

Animals↗

PubMed1996

Reciprocal projections of cat extrastriate cortex: I. Distribution and morphology of neurons projecting from posterior medial lateral suprasylvian sulcus to area 17.

Reciprocal projections between cortical areas have been subdivided into two functionally distinct component, "feedforward" and "feedback" (for review, see Felleman and Van Essen [1991] Cereb. Cortex 1:1-47). Some anatomical evidence, such as differences in the laminar distribution of the neurons of origin and of the terminations of their axons, has supported this division. However, very little is actually known about the distribution and morphology of the neurons of the feedback projections. In order to contribute further to our understanding of these two components of the corticocortical projections, I studied the distribution and morphology of a feedback projection, the reciprocal projection from the posterior medial lateral suprasylvian sulcus (PMLS), to primary visual cortex (area 17). Retrograde transport of horseradish peroxidase and fluorescent tracers in vivo combined with intracellular dye injections in lightly fixed cortical slices revealed many similarities between the feedforward and feedback projections: 1) They both emanate from all layers but layer 1; 2) each layer of origin contains a wide variety of standard and/or inverted pyramidal neurons; and 3) all of these, with the exception of a rare, large layer 5 neuron, have dendritic fields restricted principally to their layers of origin. There was, however, one major difference between the feedforward and feedback projections: In contrast to the projection from area 17 to PMLS, the projection from PMLS had a dense projection from layer 6 that compromised a striking abundance of spiny fusiform and inverted pyramidal neurons. These were morphologically distinct from other layer 6 neurons that project to the thalamus. Taken together, these data suggest that the reciprocal projections between area 17 and area PMLS, although not completely equivalent, share essential features that form a distinct population of neurons differing in morphology from corticothalamic projection neurons.

Animals↗

PubMed1989

Brainstem projecting neurons in the rat basal forebrain: neurochemical, topographical, and physiological distinctions from cortically projecting cholinergic neurons.

Magnocellular regions of the basal forebrain contain cholinergic neurons that project to the cerebral cortex. Neurons in the same basal forebrain regions innervate the brainstem. The present study investigated whether these brainstem projecting neurons are cholinergic, project also to the cortex, and share similar physiological properties as cortically projecting neurons. Data with retrograde tracing from various regions of the pons, medulla, and cortex combined with choline acetyltransferase immunofluorescence indicated that: 1) brainstem projecting neurons are usually segregated from cortically projecting and/or cholinergic neurons in the basal forebrain, 2) virtually no brainstem projecting neurons in the basal forebrain are cholinergic, and 3) only rarely do basal forebrain neurons have axon collaterals that project to both cortex and brainstem. Extracellular recordings from basal forebrain neurons confirmed the paucity of axonal collateralization and the topographic segregation between cortically and brainstem projecting basal forebrain neurons, and, in addition, showed that brainstem projecting neurons have a slower mean conduction velocity than cortically projecting neurons. These observations suggest that basal forebrain neurons projecting to the brainstem (pons, medulla) and the cortex represent separate cell populations in terms of projections, neurotransmitter content, distribution, and physiological properties.

Action Potentials↗

PubMedDate not supplied

Comparison of projection algorithms used for the construction of maximum intensity projection images.

OBJECTIVE: Four methods of producing maximum intensity projection (MIP) images were studied and compared. MATERIALS AND METHODS: Three of the projection methods differ in the interpolation kernel used for ray tracing. The interpolation kernels include nearest neighbor interpolation, linear interpolation, and cubic convolution interpolation. The fourth projection method is a voxel projection method that is not explicitly a ray-tracing technique. The four algorithms' performance was evaluated using a computer-generated model of a vessel and using real MR angiography data. The evaluation centered around how well an algorithm transferred an object's width to the projection plane. RESULTS: The voxel projection algorithm does not suffer from artifacts associated with the nearest neighbor algorithm. Also, a speed-up in the calculation of the projection is seen with the voxel projection method. Linear interpolation dramatically improves the transfer of width information from the 3D MRA data set over both nearest neighbor and voxel projection methods. Even though the cubic convolution interpolation kernel is theoretically superior to the linear kernel, it did not project widths more accurately than linear interpolation. A possible advantage to the nearest neighbor interpolation is that the size of small vessels tends to be exaggerated in the projection plane, thereby increasing their visibility. CONCLUSION: The results confirm that the way in which an MIP image is constructed has a dramatic effect on information contained in the projection. The construction method must be chosen with the knowledge that the clinical information in the 2D projections in general will be different from that contained in the original 3D data volume.

Algorithms↗

PubMed2005

A novel extension of the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections.

The general goal of this paper is to extend the parallel-beam projection-slice theorem to divergent fan-beam and cone-beam projections without rebinning the divergent fan-beam and cone-beam projections into parallel-beam projections directly. The basic idea is to establish a novel link between the local Fourier transform of the projection data and the Fourier transform of the image object. Analogous to the two- and three-dimensional parallel-beam cases, the measured projection data are backprojected along the projection direction and then a local Fourier transform is taken for the backprojected data array. However, due to the loss of the shift invariance of the image object in a single view of the divergent-beam projections, the measured projection data is weighted by a distance dependent weight w(r) before the local Fourier transform is performed. The variable r in the weighting function w(r) is the distance from the backprojected point to the x-ray source position. It is shown that a special choice of the weighting function, w(r)=1/r, will facilitate the calculations and a simple relation can be established between the Fourier transform of the image function and the local Fourier transform of the 1/r-weighted backprojection data array. Unlike the parallel-beam cases, a one-to-one correspondence does not exist for a local Fourier transform of the backprojected data array and a single line in the two-dimensional (2D) case or a single slice in the 3D case of the Fourier transform of the image function. However, the Fourier space of the image object can be built up after the local Fourier transforms of the 1/r-weighted backprojection data arrays are shifted and then summed in a laboratory frame. Thus the established relations Eq. (27) and Eq. (29) between the Fourier space of the image object and the Fourier transforms of the backprojected data arrays can be viewed as a generalized projection-slice theorem for divergent fan-beam and cone-beam projections. Once the Fourier space of the image function is built up, an inverse Fourier transform could be performed to reconstruct tomographic images from the divergent beam projections. Due to the linearity of the Fourier transform, an image reconstruction step can be performed either when the complete Fourier space is available or in parallel with the building of the Fourier space. Numerical simulations are performed to verify the generalized projection-slice theorem by using a disc phantom in the fan-beam case.

Algorithms↗

PubMed2005

Large-scale maintenance of dual projections by callosal and frontal cortical projection neurons in adult mice.

Integration of sensory-motor information in premotor cortex of rodents occurs largely through callosal and frontal cortical association projections directed in a hierarchically organized manner. Although most anatomical studies in rodents have been performed in rats, mammalian genetic models have focused on mice, because of their successful manipulation on the genetic and cell biological levels. It is therefore important to establish the normal patterns of anatomical connectivity in mice, which potentially differ from those in rats. The goal of this study is to investigate the anatomical development of callosal and frontal premotor projection neurons (CPN and FPN, respectively) in mouse sensory-motor and premotor cortex and to investigate quantitatively the potential laminar differences between these neurons with simultaneous callosal and frontal projections during development. The retrograde tracers Fluoro-Gold and DiI were injected into sensory-motor and premotor cortices, respectively, C57Bl/6 mice at different developmental times (P2, P8, P21, adult). We found that, in contrast to the case in primate and cat, there is widespread overlap in populations of long-distance projection neurons in mice; many projection neurons have simultaneous projections to both contralateral somatosensory cortex and ipsilateral frontal cortex, and a considerable number of these dual projections persist into adulthood. In addition, there are significant laminar differences in the percentage of neurons with simultaneous callosal and frontal projections, and an isolated population of layer V FPN has bilateral projections to both premotor cortical hemispheres. Taken together, our results indicate that a large proportion of individual projection neurons maintains simultaneous callosal and frontal projections in adult mice, suggesting that these dual projections might serve the critical function of integrating motor coordination information with multimodal association areas.

Animals↗

PubMed1976

[A standard projection for temporomandibular joint radiographs in oblique lateral projection].

A standard projection for temporomandibular joint radiographs in oblique lateral transcranial projection was determined by a clinical method. The individualized projections from 1644 TMJ radiographs, made with a fluoroscopic examination unit with image intensifier, were evaluated in a pilot study. A mean projection 20 degree cranial eccentric and 12 degree dorsal eccentric resulted. Reference planes were the Camper plane and the middle frontal plane. This projection, corrected in 22 degree/10 degree, was studied in a clinical study in order to test the readability of the radiographs of 100 temporomandibular joints. The readability of these radiographs was compared with that of radiographs obtained with an individualized projection. 81 radiographs out of 100 were well or very well readable, 7 were limitedly readable and 12 were unreadable. The number of radiographs in these last two categories could not be reduced by an individual angulation of the x-ray beam. Therefore anatomical reasons have to be considered to be responsible for the insufficient readability of these TMJ radiographs. This projection avoided superposition of the petrous portion of the temporal bone without giving an extreme view of the lateral slope of the condyle. From the evaluation of the 100 individualized projections resulted a mean projection 21 degree/10 degrees, which confirmed the projection 22 degrees/10 degrees used in this study. The projection 21-22 degrees/10 degrees turned out to be a most favourable projection for the dental office to make TMJ radiographs in connection with the diagnosis of the occlusion in patients with TMJ disorders.

Adolescent↗

PubMed1999

Project leadership: why project management alone doesn't work.

Projects often fall short of achieving their anticipated results, not due to a lack of project management, but rather from a lack of project leadership. Because project success is a direct reflection of the project manager, it is his or her responsibility not just to manage the details and report status of a project, but to go beyond and add value through providing leadership. Project managers can no longer update task lists and issue meeting minutes if they are to succeed. This article focuses on adapting proven leadership strategies to project environments, helping to increase the probability for project success. When properly applied, they will help turn today's project manager into tomorrow's project leader.

Attitude to Computers↗

PubMedDate not supplied

Movement of the projected pedicles relative to the projected vertebral body in a fourth lumbar vertebra during axial rotation.

BACKGROUND: One use of the anteroposterior lumbar radiograph is to determine axial (y-axis) rotation of the lumbar vertebrae. Rotation might be an element of interest to clinicians seeking to evaluate vertebral positioning. OBJECTIVES: Correlate and quantify movements of the projected pedicles relative to the projected vertebral body during axial rotation and determine if vertebral asymmetry and changes in object film distance affect these movements. DESIGN: A three-dimensional computer model of the fourth and fifth lumbar vertebrae, a modeled radiograph source, and a modeled film were produced. The vertebral model was placed in various degrees of axial rotation at a number of different object film distances. Lines from the source were passed through the pedicles of the fourth lumbar vertebral model and additional lines erected tangent to the lateral body margins. These lines were extended to points of contact with the modeled film. RESULTS: The projected pedicles move relative to the projected vertebral body during y-axis rotation. Vertebral asymmetry and object film distances can also affect the distance of the projected pedicle relative to the projected lateral body margin. CONCLUSION: Axial rotation produces movement of the projected pedicles relative to the projected vertebral body. However, vertebral asymmetry and changes in object film distance also affect the position of the projected pedicles relative to the projected lateral body margin and might serve as confounders to the clinician seeking to analyze vertebral rotation through the use of the projected pedicles.

Anthropometry↗

PubMed1995

The interdisciplinary generalist curriculum project: a national medical school demonstration project.

The United States is facing the challenge of producing more generalists for the physician workforce. The Primary Care Organizations' Consortium (PCOC) has responded by focusing on how medical education can be modified to enhance and support medical students' interest in and commitment to generalism early in their training. Evolving from PCOC's developmental work, the five-year Interdisciplinary Generalist Curriculum (IGC) Project was developed to encourage the nation's schools of medicine and colleges of osteopathic medicine to implement interdisciplinary generalist curricula in the preclinical years. Funded by the Division of Medicine in the Bureau of Health Professions of the Health Resources and Services Administration (HRSA), the IGC Project has successfully developed and implemented a nationally competitive medical school demonstration project. Thirty-three schools submitted proposals for an IGC Project award; nine were selected for site visits, from which five were chosen to receive three-year awards. Rigorous attention to creating and maintaining an interdisciplinary focus has characterized the first phase of the IGC Project. Shared leadership among the Executive Committee's project director and two project codirectors and parity in representation among the three disciplines of family medicine, internal medicine, and pediatrics on the Advisory Committee have formed a critical foundation for interdisciplinary functioning within the project. Growing national interest in generalist training and other funding initiatives have contributed to acceptance of the IGC Project. The high level of interest in the IGC Project and the successful interdisciplinary collaboration during the first phase would indicate that the interdisciplinary process can be replicated to move the nation's medical education institutions toward the production of needed generalist physicians.

Curriculum↗

PubMed2002

Ascending and descending projections from the superior olivary complex in guinea pigs: different cells project to the cochlear nucleus and the inferior colliculus.

The superior olivary complex is a source of ascending projections to the inferior colliculus and descending projections to the cochlear nucleus. We used multiple-labeling techniques with fluorescent retrograde tracers to determine whether individual superior olivary cells project to the inferior colliculus and the cochlear nucleus. Almost all labeled cells contained one tracer, suggesting that they projected to only one of the injected targets. A small number of cells sent collateral projections to the ipsilateral cochlear nucleus and ipsilateral inferior colliculus. The double-labeled cells constituted fewer than 2% of the cells that projected to the cochlear nucleus or to the inferior colliculus. There was no evidence for cells projecting to both contralateral targets or to one ipsilateral target and one contralateral target. We conclude that the ascending projections to the inferior colliculus and the descending projections to the cochlear nucleus arise almost exclusively from separate populations of cells in the superior olivary complex. Their separate origins suggest that these projections are sending different information to higher and lower centers of the auditory pathways.

Animals↗