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Results for “PROTEUS INFECTIONS”

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At least 19 recordsLinked to original sources
PubMed1983

[Vaccine from soluble antigens for the specific therapy of Proteus infection].

A vaccine prepared from Proteus soluble antigens obtained by the disintegration of microbial cells with hydroxylamine is proposed. In animal experiments the vaccine has proved to be nontoxic when injected in large single doses or in smaller doses over a prolonged period and capable of protecting mice and rabbits from Proteus infection. No pronounced postvaccinal complications have been registered in humans immunized with the vaccine. The possibility of using the vaccine for immunizing donors with the aim of obtaining hyperimmune anti-Proteus plasma and for the active vaccinal therapy of patients with Proteus infection has been shown.

Animals↗
PubMed1982

[Serodiagnosis and immunological aspects of Proteus infection. III. Immunological, bacteriological and pathomorphological parallels in experimental Proteus intestinal infections, mono- and mixed].

The intraintestinal infection of 76 rabbits with P. mirabilis in a dose of 10(9) cells/kg, alone or in combination with Sh. sonnei, by the method modified by the authors caused a pathological process in the intestine, which was indicative of Proteus playing an independent role in the etiology of diarrheas. The process had its pronounced clinical, microbiological and immunological characteristics. Specific immunoglobulins, mainly H-antibodies, could be detected in different serological tests with the corresponding antigens, their pattern, level and avidity objectively reflecting the development of the infectious process. In mixed infections the pattern of the contamination of feces with the infective agents and their ability to form colonies after the inoculation of fecal samples were changed, while the level of antibodies to the associates was lower than in monoinfections.

Animals↗
PubMedDate not supplied

Septicemic proteus infection in Japanese quail chicks (Coturnix coturnix japonica).

Proteus infection was incriminated as the cause of severe depression, coma, and high mortality in successive broods of quail chicks. The pathological lesions comprised congestion of lungs, liver, and kidneys and mucus exudation in the trachea. The organism, isolated from the heart blood and lungs of affected chicks, was identified on biochemical tests as Proteus mirabilis. Pathogenicity of the isolate was tested in young albino mice and week-old quail chicks, which succumbed to infection within 48 hours of inoculation. Association of P. mirabilis with septicemic disease in Japanese quails has apparently been demonstrated for the first time.

Animals↗
PubMed1982

[Serodiagnosis and the immunological aspects of Proteus infection. IV. Serum antibody level and the pathomorphological and bacteriological indices in experimental mixed and monoinfections of the urinary tract].

In developing the serodiagnosis of the Proteus infection of the urinary tract experimental hematogenic Proteus or Proteus-Escherichia pyelonephritis was reproduced. In this infection the time course, level and avidity of serum antibodies correlated with the isolation of the causative agents from urine samples used as seed material and with histological changes in the kidneys. The serological tests revealed high titres of H-antibodies and the presence of O-antibodies, while in cases of bacteriuria not accompanied by kidney lesions only H-antibodies in low titers were detected. The results obtained in the study of immune shifts can be used for etiological diagnosis and more exact localization of the pathological process in the urinary system.

Animals↗
PubMed1982

[Increased effectiveness of antibiotic therapy with adaptogens in dysentery and Proteus infection in children].

The course of the disease and the host immunological reactivity (IgA, IgM, IgG, CPhI, IgG and IgM antibody titers in the HIT, blood bactericidic properties) were studied in 258 children aged 0 to 14 year suffering from acute dysentery caused by Shigella sonnei and flexneri and enterocolitis of the Proteus etiology. 157 patients were treated with monomycin and kanamycin in combination with adaptogens, such as Eleuterococcus and Echinopanax elatum Nakai L. and 101 patients were treated with the antibiotics alone. It was shown that the use of the adaptogens decreased the periods of the diseases. It is concluded that adaptogens increase the efficacy of antibiotic therapy in children with dysentery and Proteus infection.

Acute Disease↗
PubMed1980

[Use of the edema test of the extremities in white mice for studying purulent Proteus infection].

The injection of non-enterotoxigenic Proteus strains into the paw pad of white mice caused paw edema, its intensity being proportional to the dose used for the test. The exudate consisted of granulocytes. Immunization with isolated Proteus antigens prevented the development of edema. This test is recommended as a model of local purulent infection. The optimal methods for the statistical analysis of the results thus obtained is proposed.

Animals↗