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At least 19 recordsLinked to original sources
PubMed1961

Antagonism of apomorphine-induced pecking in pigeons.

Central nervous system stimulants, tranquillizers and other central nervous system depressants, antiemetics, antihistamine drugs and autonomic blocking agents were examined for their ability to prevent the pecking response in pigeons induced by apomorphine (250 mug/kg intramuscularly). Reduction in the proportion of positive responses or significant increase in the latent period of pecking were taken as the criterion of effectiveness. Protection was afforded by caffeine, lysergic acid diethylamide, morphine, rauwolscine, triflupromazine and yohimbine. In addition, a significant increase in latent period was produced by artane, pentobarbitone, benactyzine, 2-bromolysergic acid diethylamide, cyclizine, diphenhydramine, ergotoxine, hyoscine, promethazine, 5-(2-chloroethyl)-4-methylthiazole and trimethobenzamide. Most of these drugs influenced the pecking and emetic responses to apomorphine in an identical manner. It is possible that identical receptors may be concerned with apomorphine pecking (in pigeons) and emesis (in other species).

Animals↗
PubMed1961

Instrumental conditioning of jugular self-infusion in the rhesus monkey.

A technique is described for self-infusion of pharmacologic agents in solution through a permanently indwelling jugular catheter in the rhesus monkey. The results of an experiment utilizing this technique demonstrate that an instrumental lever response can be conditioned, extinguished, reconditioned, and brought under stimulus control and reward-schedule control with saline self-infusion as the reinforcing stimulus.

Animals↗
PubMed1961

10-Methoxyharmalan, a potent serotonin antagonist which affects conditioned behavior.

10-Methoxyharmalan, an alkaloid obtained by the cyclodehydration of melatonin, itself a derivative of serotonin, is a more potent serotonin antagonist than harmaline and is only slightly less active than lysergic acid diethylamide. It has a similar, yet slightly greater, effect on behavior as that of harmaline and is the most potent serotonin derivative, so far tested, that affects the avoidance-escape behavioral reflex

Lysergic Acid Diethylamide↗