PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “PURPURA, THROMBOTIC THROMBOPENIC”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed1986

[Partial remission of fulminant thrombotic-thrombopenic purpura (Moschcowitz syndrome) by infusion of fresh plasma].

In addition to the typical manifestations of thrombotic-thrombocytopenic purpura like thrombocytopenia, haemolysis, fever, coma and renal failure, signs of a beginning DIC could be seen in a patient after abdominal surgery. Haemostatic, cardiovascular and respiratory data are presented. Pulmonary angiography by using a Swan-Ganz-catheter revealed multiple filling defects reversible with therapy. Treatment with fresh whole blood aggravated thrombocytopenia. Daily infusions of fresh frozen plasma combined with heparinisation and antithrombin III because of DIC, induced haematologic remission. Renal failure and cerebral symptoms could not be influenced. Diagnosis, monitoring and therapy are discussed.

Appendectomy↗
PubMed1996

[A case of thrombotic thrombopenic purpura. Literature review].

We report the case of a 70 years old woman who developed a thrombotic thrombocytopenic purpura. Despite a treatment with corticoids and high doses IV gammaglobulins, the patient developed seizures. Treatment with plasma exchanges combined with plasma infusions allowed recovery. The authors review the clinical and biological aspects as well as the pathogeny of the disease. The authors insist on the importance of the plasma exchanges in the treatment of this disease.

Aged↗
PubMed1983

[Thrombotic thrombopenic purpura associated with Hodgkin's disease].

We report the second case of Hodgkin's disease associated with thrombotic thrombocytopenic purpura (TTP). Although the two diseases coexisted originally, TTP was diagnosed alone at first. Because of the very rare occurrence of this association the diagnosis of TTP is discussed according to the accepted criteria and taking into account the haematological complications which can reveal or be observed in Hodgkin's disease. No evident relationship between the two diseases can be suggested. But immunologic disorders observed in the two cases suggests that their coexistence is not necessarily accidental. The evolution of these two diseases is particularly good.

Adult↗
PubMed1994

[Thrombotic thrombopenic purpura and HIV infection. Apropos of a case].

In the past years, more than thirty cases of thrombotic thrombocytopenic purpura (TTP) had been described associated to infection by the human immunodeficiency virus. Some authors have suggested the presence of a causal relationship between both entities, although the common nexus is still unknown. It usually has a fulminant onset, affecting all the risk groups and in any stage of the disease. The clinical manifestations are similar to the classical forms, as well as the evolution and response to treatment. We present a new clinical case, typical in its presentation and its good response to treatment with plasmatic spares associated to PFC and steroid infusion. We believe that the presence of clinical signs suggesting TTP in a patient would necessarily discard the presence of HIV infection and, the other way round, the presence of clinical signs suggesting TTP in a patient with HIV infection would determine the onset of an early and aggressive treatment based on plasmatic spares, given that the prognosis is linked to an early onset of the treatment.

Adult↗
PubMed1984

[Differential therapy of thrombotic-thrombopenic purpura. Administration of fresh plasma versus plasma separation].

In a 29-year-old man with primary thrombotic-thrombocytopenic purpura a significantly increased plasma concentration of platelet-specific proteins was demonstrated as an expression of increased intravascular platelet activation and destruction during the acute phase of the disease. There was also abnormally elevated IgG loading of platelets. During administration of fresh plasma alone (total of six litres over one week) the clinical state deteriorated further into coma and failure of spontaneous ventilation. The marked thrombocytopenia and microangiopathic haemolytic anaemia remained unchanged. Only after repeated plasmapheresis was it possible to break through the acute disease process. Remission (restoration of vital functions, normalization of platelet count and haemolysis signs) was achieved after five courses of plasmapheresis with a total exchange volume of 20 litres. At least in this case, the therapeutic success of plasmapheresis argues for an immunological-toxic genesis of thrombotic-thrombocytopenic purpura.

Acute Kidney Injury↗
PubMed1991

[Treatment of thrombotic thrombopenic purpura. Results of a multicenter randomized clinical study].

A controlled multicentre trial was conducted in France over a period of five years in 40 patients with thrombotic thrombocytopenic purpura (TTP) to try to determine the best treatment of this disease. Patients presenting eligibility criteria were centrally randomized into two therapeutic groups: Group A) daily plasma exchanges with a solution of fresh frozen plasma (15 ml/kg) in albumin (45 ml/kg) versus Group B) daily transfusions of fresh frozen plasma (15 ml/kg), both systematically associated with intravenous antiplatelet therapy. When the treatment was started early after the first symptoms of TTP, there was no significant difference among plasma exchange and plasma transfusion. But the later the treatment was started, the lesser was the initial therapeutic response and the poorer the prognosis. Furthermore, the excessive use of plasma transfusions in initially unresponsive patients could be dangerous, resulting in some cases in irreversible development of the disease. The overall survival rate in groupe A was 85 percent with 80 percent complete remissions and 15 percent deaths, as opposed to a 57 percent survival rate with 52 percent complete remission and 43 percent deaths in groupe B. Thus plasma exchanges with fresh frozen plasma if started early and performed daily in sufficient amounts, appear to be undoubtedly safer than plasma transfusions.

Adult↗