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At least 19 recordsLinked to original sources
PubMed1998

Basaloid squamous cell carcinoma: a distinctive human papilloma virus-related penile neoplasm: a report of 20 cases.

Most penile neoplasms are squamous cell carcinomas (SCC), but there are subtypes that show morphologic and possibly etiologic differences. Clinicopathologic features of 20 patients with basaloid carcinoma (BC), an unusual variant of squamous cell carcinoma, are presented. Median age was 52 years, and all tumors were located in the glans, three confined to the perimeatal region. Average tumor size was 3.8 cm. Microscopically, nests of small, basophilic cells with numerous mitosis were present. Human papillomavirus DNA sequences (type 16), using the polymerase chain reaction (PCR), were found in 9 of 11 cases. Differential diagnosis included urethral transitional cell, basal cell, small cell neuroendocrine, and metastatic carcinoma. Factors more significantly associated with regional metastasis and mortality were tumor thickness greater than 10 mm and infiltration of the corpus cavernosum. A comparison with typical squamous cell carcinoma showed basaloid carcinoma to have a higher histologic grade, a deeper invasion of penile anatomic levels, and a higher mortality rate. Of 17 patients observed, 10 were dead of disease (average time, 34 months), one was alive with disease 6 months after diagnosis, and 5 were alive and free of disease (average time, 71 months); the remaining patient died of other causes. Basaloid carcinoma is a distinctive morphologic subtype of squamous cell carcinoma frequently associated with the human papilloma virus.

Adult↗
PubMedDate not supplied

Imaging of penile neoplasms.

The assessment of penile cancer on the basis of clinical findings alone can often result in inaccurate staging and suboptimal treatment. Imaging of primary penile cancer and metastatic lymphadenopathy can help optimize planning of both primary tumor resection and treatment for lymph node metastases. Magnetic resonance (MR) imaging is the most accurate imaging modality in the assessment of primary penile cancers, which usually manifest as solitary, ill-defined infiltrating tumors that are hypointense on both T1- and T2-weighted MR images. T2-weighted MR imaging allows delineation of the tumor margin and of any extension into the penile shaft. On gadolinium-enhanced T1-weighted images, the tumors enhance to a greater extent than do the corpora cavernosa. In addition, the recently introduced technique known as lymphotrophic nanoparticle-enhanced MR imaging can help identify metastatic lymph node disease. However, further studies will be needed to determine the role of this imaging technique in clinical practice. Computed tomography does not clearly depict the local extension of primary penile cancer; however, it is useful in assessing metastases and postoperative complications.

Humans↗
PubMed2003

Cytological diagnosis of nonulcerative penile neoplasms: report of two cases.

Nonulcerative penile mass lesions are rare. Pathological diagnosis of these lesions would traditionally be a biopsy. We report two such primary penile lesions which were diagnosed by fine-needle aspiration cytology (FNAC). Both lesions were present in the shaft and were diagnosed as squamous cell carcinoma (SCC). The first patient had a recurrence on the penile stump of partial amputation without any ulceration. The second had a primary urethral carcinoma on the terminal penile shaft infiltrating the corpora cavernosa dorsally. Open biopsies were avoided in both cases. FNAC was associated with very little and tolerable discomfort. There were no complications. The aspirate yield was sufficient for cytological diagnosis. FNAC of nonulcerated penile lesions is safe, well tolerated, and capable of providing a cytological diagnosis. Hence, it is a very useful outpatient procedure and could be the procedure of choice for diagnosis.

Aged↗
PubMed1996

Squamous cell carcinoma of the penis.

Penile tumors, although not frequent, represent a difficult diagnostic and therapeutic challenge. Of the malignant penile neoplasms, the most frequent is penile carcinoma, which includes squamous cell carcinoma and its well-differentiated variant, verrucous carcinoma. Current concepts about classification, epidemiology, pathogenesis, histopathology, diagnosis, staging, prognosis, and treatment are presented.

Carcinoma in Situ↗