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[Influence of diagnostic information on visual action of interpretation].

Pertinent information used in radiographic diagnosis consists mainly of abstract abnormal findings. Experience has show that the reasoning process required to interpret this information is the most important element of a proper diagnosis. Thus, it is important to combine the results of radiograms with information obtained through actual observation of oral cavities. To reveal the thinking process required while reading radiograms, it is important to have an objective study in which visual action is followed as a reference. For this reason, studies on visual action have been conducted in the fields of medicine and dentistry using eye movement recording systems. In the field of medicine, Kundel and Nodine reported on visual actions while subjects were engaged in reading chest radiograms. In the field of dental medicine, and especially in oral diagnostics, Yamano et al. introduced an eye mark recorder which quantitatively analyzed the visual action of dentists during radiographic diagnosis. This device may lead to important information which can be used in making diagnoses, especially quantitative information. They concluded that the eye mark recorder is effective for quantitative evaluation of the thinking process during radiographic diagnoses. Thus, we focused our attention on visual action in analyzing the thinking process during radiographic diagnosis and by means of such analytical techniques, studied how information obtained from oral diagnostics can affect the thinking process during radiographic diagnosis. (1) The equipment used was the visual action analysis system. (2) Seventy-five dentists were engaged in reading radiograms for this study. (3) The radiograms we used included two pictures of marginal periodontitis and periapical periodontitis. (4) Diagnostic information given. Group A: none, group B: chief complaints, and group C: chief complaints, present symptoms and history of the present illness. We investigated how prior presentation of such information would affect visual action during radiographic diagnosis, and obtained the following results. 1. Newly-developed correction system. The newly-developed correction system made it possible to detect the fixation point more precisely by correcting head movement in real time. 2. Effect of prior oral diagnostic information on visual action during radiographic reading. 1) Effect on total fixation time. For both marginal periodontitis and periapical periodontitis, the total fixation time was shorter in group C than in groups A and B. 2) Effect on the total fixation time spent on decayed teeth. For both marginal periodontitis and periapical periodontitis, the total fixation time spent on decayed teeth was longer in group B than in groups A and C.(ABSTRACT TRUNCATED AT 400 WORDS)

Decision Making

Differential localization of type I and type III procollagen messenger ribonucleic acids in inflamed periodontal and periapical connective tissues by in situ hybridization.

Inflammatory lesions of periodontal and periapical connective tissue were studied by in situ hybridization to detect cells responsible for type I and type III collagen production. Formalin-fixed and paraffin-embedded tissue specimens from patients with oral lesions of various stages of inflammation were hybridized with cDNA probes specific for human pro alpha 1(I) and pro alpha 1(III) collagen mRNAs, and with bacteriophage lambda DNA as a control probe. This technique permitted us to localize fibroblasts active in type I collagen synthesis in the vicinity of inflammatory infiltrates in all the samples studied. Cells containing high levels of type III collagen mRNA were seen in early abscess formation and they were particularly abundant in pyogenic granuloma and irritation fibroma. Type I collagen mRNA was prominent in gingival fibrosis. In the infrabony lesions with active inflammatory infiltrations the production of collagen was confined mostly to the periphery of the lesions. These findings give indirect evidence that cytokines liberated during the early stages of the inflammatory process stimulate expression of the type III collagen gene by fibroblasts. In chronic lesions a gradual switch from type III to type I collagen gene expression occurs. The change in collagen types appears to underlie the observed isolation of the inflammation by a collagenous capsule. In all the samples studied fibroblasts exhibited marked variation in their levels of procollagen mRNAs, supporting previous views about their heterogeneity in connective tissues. The approach presented here offers new possibilities to study cellular interactions and metabolic activities in inflammatory lesions.

Adolescent

[Effect on the development of permanent successors due to the extraction and non-extraction of infected deciduous teeth].

The purpose of this study was to clarify the effects on the eruption and root formation of the permanent successors of deciduous teeth affected by periapical periodontitis. Materials used were forty-one healthy infant dogs about two months old. Standardized X-ray films were taken every two weeks. The period of study ran from the age of ten weeks to twenty eight weeks until the roots of the permanent successors were completed. A total of 328 mandibular teeth were used and classified as P2 and P3 with their preceding deciduous teeth being Dp2 and Dp3. The following four groups were used in this experiment. 1) Extraction group with infected deciduous teeth: The infected deciduous teeth were extracted after being left for four weeks following pulpectomy. 2) Extraction group with healthy deciduous teeth: Healthy deciduous teeth were extracted from fourteen-week olds. 3) Left-alone group with infected deciduous teeth: After pulpectomy the infected deciduous teeth were left until they were shed naturally. 4) Healthy group (control): Untreated teeth were observed which represented the opposites of all the teeth examined in the previous three groups. A study was made of the changes in location, eruption and root formation of the permanent successors of deciduous teeth in affected with periapical periodontitis and the condition of eruption and root formation of the permanent successors. The result were as follows. 1. Appearance rate of periapical periodontitis: 1) DP2: Two weeks after pulpectomy, periapical periodontitis was observed in eleven out of twenty-one teeth (52.4%), and after four weeks in seventeen out of twenty-one teeth (81.0%). 2) Dp3: Two weeks after pulpectomy, periapical periodontitis was observed in eighteen out of twenty-one teeth (85.7%), and after four weeks in all of the experimental teeth. The appearance rate of periapical periodontitis in Dp3 was higher than in Dp2. 2. Eruption of permanent successors: 1) Extraction group with infected deciduous teeth: (1) The eruption of permanent successors was accelerated more than the other experimental groups. This tendency was stronger in P3 than in P2. (2) There were changes in location in the upper and lower directions of P2 before extraction of Dp2, in the lower direction for P3 before extraction of Dp3, and in the upper direction for P2 and P3 after extraction of Dp2 and Dp3. 2) Extraction group with healthy deciduous teeth: (1) Eruption of P2 appeared to be almost the same as the control group, but the eruption of P3 was delayed slightly at the eruption from the alveolar bone.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals

Periodontal repair of periapical lesions: the borderland between pulpal and periodontal disease.

A series of cases demonstrating the destruction of periapical periodontal structures, without pulpal involvement has been presented. Treatment using both surgery and antibiotics resulted in extensive healing without any concommitant endodontic therapy. The results suggest that lesions affecting the apical periodontium are either periodontal or pulpal in origin. Careful diagnosis allows the maintenance of pulp vitality in cases where apical destruction has a source other than an infected pulp. The commonly held belief that lateral and accessory canals are a significant source of pulpal contamination from deep periodontal pockets has been questioned.

Adult

[Endodontic treatment of chronic apical periodontitis without periapical medication].

The aim of this research was to evaluate the clinical course of chronic apical periodontitis (CAP), treated only endodontically, without periapical medication. Chronic apical periodontitis cases of pulpal origin were used as a material and treated endodontically as individual clinical cases. Clinical and statistical procedures were applied. The percentage of efficient or non-efficient cases was evaluated on the basis of radiographic comparison of treated CAP immediately after obturation, and six months later. Influences of various factors on therapy effect were analysed: radiographic condition and type of periapical lesions, apical level of canal obturation, group of teeth and jaws as well as age. Radiographic conditions were assessed as status quo, improvement or deterioration. Final results were: 67.3% of improvement, 27.2% of status quo and 5.5% deterioration.

Chronic Disease

Histologic reactions to a newly developed calcium phosphate cement implanted in the periapical and periodontal tissues.

A newly developed calcium phosphate cement (CPC), basically composed of tetracalcium phosphate, Ca4(PO4)2O and dicalcium phosphate dihydrate, CaHPO4.2H2O or anhydrous calcium phosphate, CaHPO4, was tested in this study. When combined with water, the cement hardens and produces hydroxylapatite resembling the principal mineral of teeth and bones. Therefore, the CPC should be highly compatible with the body. However, before its clinical application in dentistry, the biocompatibility of CPC in the potential environments of implantation needs confirmation. Eight monkeys were used in our study to test the material in the periapical and marginal periodontal regions. Surgically created periodontal defects were implanted with CPC and hydroxylapatite (HA) (Calcitite 4060). In another application, CPC was pushed into the periapical areas via overfilling of the root canals. Sargenti N2 served as the control material in the periapical test. Generally, only a limited inflammatory response to CPC was found after 6 weeks of implantation in the periodontal area. In the 16-week specimens, the adverse reaction was negligible, and bone regeneration was marked and directly surrounding the CPC. The bone formation activity and biocompatibility in general were found to be even better in the periapical region. The results suggest that the CPC may have a good potential in future clinical applications, although many issues remain to be investigated.

Animals