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At least 19 recordsLinked to original sources
PubMed1979

Polymorphism, genetic stability, and autosomal location of trimeric nucleoside phosphorylase in Peromyscus eremicus cell lines.

Nucleoside phosphorylase (NP: EC 2.4.2.1) has not been demonstrated to be an extensively polymorphic enzyme locus in mammals. We have studied NP electrophoretically in five independently derived cell lines established from Peromyscus eremicus as well as in various tissues of a sixth animal. Four different NP phenotypes involving three different alleles were resolved. The data suggest that (1) the enzyme is trimeric and its genetic locus is polymorphic in P. eremicus, (2) heterozygous enzyme phenotypes are stable during long-term culture, and (3) the enzyme locus is autosomal in Peromyscus.

Alleles↗
PubMed1978

Peromyscus alcohol dehydrogenase: lack of cross-reacting material in enzyme-negative animals.

Two forms of alcohol dehydrogenase (ADH), coded by allelic genes, have been purified to homogeneity from Peromyscus. Monospecific antisera to the purified enzymes have been raised in rabbits. These antisera fail to detect cross-reacting material in the liver of ADH-negative animals on Ouchterlony plates. Immuno-titration of anti-ADH antiserum with ADH in liver extracts from AdhS/AdhS and AdhS/AdhN animals results in identical equivalence points, again suggesting the absence of cross-reacting material coded by the AdhN allele. Over a wide range of anti-ADH antiserum dilutions, radiolabeled protein was not immunoprecipitable from liver extracts of AdhN/AdhN animals. These immunochemical tests, in conjunction with previous studies, suggest that the AdhN allele in Peromyscus does not produce inactive polypeptide in normal levels that bears immunological determinants similar to those of the fast and slow ADH isozymes.

Alcohol Oxidoreductases↗
PubMed1979

Odontomas in Peromyscus leucopus.

A colony of Peromyscus leucopus was established 15 years ago from animals trapped in the deciduous forest at Argonne National Laboratory, Argonne, Illinois. A roentgenographic survey of the skeletons of 189 of these untreated animals dying during a 13-month period disclosed 48 odontogenic growths in 21 of the mice. These growths were diagnosed on histopathologic examination as complex odontomas, the incidence of which was higher in males than in females. In this relatively small sample, these benign tumors appeared to be associated with youth rather than old age.

Age Factors↗
PubMed1975

Hereditary cataracts in deer mice (Peromyscus maniculatus).

A new type of hereditary cataract was predicted in the deer mouse (Peromyscus maniculatus) by the presence of syndactyly of the hind feet. Early morphologic changes were found in the equatorial cells that differentiated into new lens fibers. Later swelling at the anterior and posterior poles of these cells produced lens opacities. Anterior and posterior subcapsular cataracts progressed to a hypermature shrunken lens.

Animals↗
PubMed1977

Effects of vaginal-cervical stimulation in seven species of muroid rodents.

Six species of muroid rodents (Peromyscus californicus, P. eremicus, P. gossypinus, Mesocricetus auratus, Rattus norvegicus and R. rattus) were given artificlal vaginal-cervical stimulation in an attempt to induce pseudopregnancy. Some females of each species became pseudopregnant, but it was not clear that stimulation patterns mimicking the copulatory patterns of conspecific males were more effective than other patterns of stimulation. In the non-domesticated species (Peromyscus and R. rattus) a few females responded to a variety of stimulus conditions, and no species differences in responsiveness among the wild species were evident. The established laboratory rodents (R. norvegicus, M. auratusy were markedly more responsive to artificial stimulation, suggesting possible effects of domestication on fecundity and reactions to handling- Microtus ochrogaster, an induced ovulator, ovulated in response to vaginal-cervical stimulation only if one intromission from a male was also provided. No other differences in the responses of reflex and spontaneous ovulators were apparent.

Animals↗
PubMed1979

Studies in heterochromatin DNA: accessibility of late replicating heterochromatin DNA in chromatin to micrococcal nuclease digestion.

Heterochromatin DNA in cactus mouse (Peromyscus eremicus) replicates in the late S phase of cell cycle. A method of obtaining cells which contain DNA preferentially labeled at heterochromatic areas by a pulse-labeling of late replicating DNA is described. When the nuclei of P. eremicus cells containing radioactively labeled DNA in heterochromatin were digested with micrococcal nuclease and the resultant nucleosomal DNA was separated by gel electrophoresis, it was found that the repeat length of nucleosomal DNA in the heterochromatin DNA is not different from that of the bulk of the genomic DNA. Furthermore, there was no significant difference in the accessibility to digestion by micrococcal nuclease between the late replicating heterochromatin DNA and the total DNA under our digestion conditions. Two dimensional gel electrophoresis patterns of nucleosomal DNAs isolated from micrococcal nuclease digested nuclei from P. eremicus, P. collatus, and P. crinitus cells in culture were very similar. Cytogenetic data showed that these three species are different in heterochromatin but similar in euchromatin.

Animals↗
PubMed1978

Preferences by deer mice for solutions of sugars, salts, and acids in Richter-type drinking tests.

Deer mice (Peromyscus maniculatus) were tested for taste preferences in 48-hour, Richter-type drinking tests (sapid solution versus distilled water). The Ss, which were seven male and seven female wild adults, were individually housed within an environmental chamber. Test solutions were concentrations of five sugars and three salts (.005 M to 1.0 M) and of two acids (4.0 pH to 1.5 pH). The molar range was too limited to identify the most preferred concentration of glucose, but peak preferences for the other common sugars fell within the range. Preference was shown for hypotonic NaCl concentrations, but other salts and both acids were nonpreferred in all tests. Comparisons were made between these findings and results from Richter-type tests with other murine rodents.

Acids↗