SEARCH · PubMed Health

Results for “Physical function”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources

PubMed1990

An objective measure of physical function of elderly outpatients. The Physical Performance Test.

Direct observation of physical function has the advantage of providing an objective, quantifiable measure of functional capabilities. We have developed the Physical Performance Test (PPT), which assesses multiple domains of physical function using observed performance of tasks that simulate activities of daily living of various degrees of difficulty. Two versions are presented: a nine-item scale that includes writing a sentence, simulated eating, turning 360 degrees, putting on and removing a jacket, lifting a book and putting it on a shelf, picking up a penny from the floor, a 50-foot walk test, and climbing stairs (scored as two items); and a seven-item scale that does not include stairs. The PPT can be completed in less than 10 minutes and requires only a few simple props. We then tested the validity of PPT using 183 subjects (mean age, 79 years) in six settings including four clinical practices (one of Parkinson's disease patients), a board-and-care home, and a senior citizens' apartment. The PPT was reliable (Cronbach's alpha = 0.87 and 0.79, interrater reliability = 0.99 and 0.93 for the nine-item and seven-item tests, respectively) and demonstrated concurrent validity with self-reported measures of physical function. Scores on the PPT for both scales were highly correlated (.50 to .80) with modified Rosow-Breslau, Instrumental and Basic Activities of Daily Living scales, and Tinetti gait score. Scores on the PPT were more moderately correlated with self-reported health status, cognitive status, and mental health (.24 to .47), and negatively with age (-.24 and -.18). Thus, the PPT also demonstrated construct validity. The PPT is a promising objective measurement of physical function, but its clinical and research value for screening, monitoring, and prediction will have to be determined.

Activities of Daily Living↗

PubMed1991

Predictors of physical functioning after a cardiac event.

An increased understanding of the factors that promote or hinder patients' return to optimal activity levels after a cardiac event is necessary to help them achieve this goal. Accordingly, the purpose of this study was to examine psychologic resources, depression, physical recovery, and illness severity for their relationships with subjective and objective physical functioning (exercise data). A correlational survey design was used to assess patients' (n = 46) illness responses 9 weeks after the cardiac event. Patients also participated in a symptom-limited exercise test. The findings suggested that the individual's return to greater activity levels after a cardiac illness was associated with less depression and illness severity, and higher levels of objective physical functioning, physical recovery, and self-esteem. Further, patients' objective physical functioning was associated not only with greater subjective physical functioning but also with greater levels of physical recovery and mastery.

Activities of Daily Living↗

PubMed1990

Short-term variability of measures of physical function in older people.

Self reported physical function was assessed in telephone interviews approximately 3 weeks apart for a sample of 193 persons aged 69 or older. Three measures of physical function were used: a modified Activities of Daily Living scale, three items proposed by Rosow and Breslau, and five items from among those used by Nagi. Agreement between first and second interviews was very good; most subjects reported no impairment in function at either interview. Among those who reported some impairment, the degree of limitation within the specific activities reported as limited and the total number of activities with any degree of limitation agreed exactly for most and within one level for almost all subjects. There was no evidence to suggest that age or cognitive impairment affected the variability of the responses, and reported declines and improvements in function were about equally common.

Activities of Daily Living↗

PubMed1992

Decline in physical function following hip fracture.

OBJECTIVE: The main objective of the study was to determine the change in physical function following hip fractures in a community-living elderly population. A secondary objective was the determination of baseline factors predictive of altered function following hip fracture. DESIGN: Prospective, cohort study. SETTING: Urban, community-living elders. PARTICIPANTS: 120 members of a cohort of 2806 individuals age 65 and older in New Haven, CT who sustained a hip fracture from 1982 to 1988 and were treated in the two New Haven hospitals. OUTCOME MEASURE: Self-reported performance of dressing, transferring, walking across a room, climbing stairs, and walking one-half mile before the fracture occurred and 6 weeks and 6 months post-fracture. Baseline factors were assessed before the hip fracture occurred. RESULTS: Of the 120 cohort members who sustained a hip fracture in the 6-year study period, 22 died within 6 months of the fracture. Among survivors there was a sustained decline in function at 6 weeks after the fracture with little improvement by 6 months. At baseline, 86% could dress independently versus 49% at 6 months; 90% could transfer independently versus 32% at 6 months; 75% could walk across a room independently versus 15% at 6 months; 63% could climb a flight of stairs versus 8% at 6 months; and 41% could walk one-half mile versus 6% at 6 months. Physical function and mental status were the only baseline factors significantly associated with physical function at 6 months after the fracture in bivariate analysis, while physical function and depression were associated in multivariate analysis. CONCLUSION: We found a substantial decline in physical function following hip fracture in a prospectively followed community-living elderly population. Only pre-morbid physical and mental function predicted this decline.

Activities of Daily Living↗

PubMed2026

DNA methylation signatures in skeletal muscle associated with physical function in healthy older adults.

Despite the substantial variability in physical function among older adults, the molecular mechanisms remain poorly characterized, particularly within skeletal muscle. This study aimed to determine the patterns of DNA methylation in skeletal muscle associated with physical function in healthy older adults. We analyzed DNA methylation (EPIC v2 array; 875,554 CpG sites) in skeletal muscle from 92 healthy older adults (median age 74; 62% female). Associations were examined across five phenotypes: Short Physical Performance Battery (SPPB), 6-min walk test (6MWT), handgrip strength, perceived disability (PAT-D), and lifestyle health (modified Life's Essential 8). Linear regression models adjusted for age, sex, race, BMI, and muscle fiber composition. Genomic inflation corrected via the BACON method (FDR < 0.05). Gene set enrichment analysis was performed on suggestive hits (FDR < 0.1). We identified significant differentially methylated probes (DMPs) and regions (DMRs) across all phenotypes: SPPB (70 DMPs, 22 DMRs), 6MWT (16 DMPs, 566 DMRs), handgrip strength (2 DMRs), PAT-D (19 DMPs, 1 DMR), and lifestyle health (2 DMPs). DMRs largely overlapped promoters. Identified genes overlapped known musculoskeletal and neurological GWAS hits, including RUNX2 and FOXL1 (bone mineral density), IGFBP3 (muscle mass), and NEK1 and SHANK1 (neurological function). Enrichment analysis revealed that 6MWT-associated genes relate to nervous and skeletal system development, while handgrip-associated genes involve cytoskeletal dynamics and protein assembly. Epigenetic variation in aging skeletal muscle is associated with physical function. The enrichment of pathways related to nervous and musculoskeletal development suggests specific epigenetic mechanisms underlying functional decline, offering potential targets for intervention in older adults.

DNA methylation↗

PubMed1991

Knee osteoarthritis and physical functioning: evidence from the NHANES I Epidemiologic Followup Study.

Although osteoarthritis (OA) is common among adults, little is known about its long-term impact on physical function. Therefore, in a cohort of 2,884 adults aged 45 years or older, [National Health and Nutrition Examination Survey I (NHANES I 1971-1975)] we examined the association of baseline radiographic knee OA and difficulty in physical functioning 10 years later (NHANES I Followup Study 1982-1984). In sex specific analyses, after controlling for age, race and length of followup, persons with radiographic knee OA were more likely than persons without knee OA to report difficulty with physical functioning, particularly for activities involving mobility, transfer and instrumental activities of daily living. However, the association of knee OA with physical functioning was influenced by the radiographic grade of OA and knee pain at NHANES I, suggesting that disease severity and pain are important in anticipating difficulties with physical functioning in persons with knee OA.

Adult↗

PubMed1990

Alcohol use and limitations in physical functioning in a sample of the Los Angeles general population.

The authors examined the relationships between drinking and perceived current health and physical functioning for a general household sample of Mexican Americans and non-Hispanic whites. These relationships differed by sex and by the presence or absence of medical and psychiatric comorbidity, but not by ethnicity. Among men with a chronic medical illness, current abstinence was uniquely associated with poor current health and physical functioning, especially when current abstinence was combined with a past history of alcohol disorder. Among men without a chronic medical illness, a history of alcohol disorder (irrespective of current drinking) was uniquely associated with poorer functioning. For women, among the medically or psychiatrically ill, drinking was not strongly associated with physical functioning; while among women without chronic medical or psychiatric illness, a history of drinking was uniquely associated with poor physical functioning. The authors interpret the findings in terms of adverse effects of drinking and chronic medical conditions on functioning and the tendency of physically limited and chronically medically ill persons to stop drinking.

Activities of Daily Living↗

PubMedDate not supplied

Quantification of lumbar function. Part 6: The use of psychological measures in guiding physical functional restoration.

The present article reviews the use of psychologic measures in guiding a functional restoration treatment program with chronic low-back pain patients. The results of the first 134 consecutive patients completing this program are reviewed. These results demonstrate that various psychologic measures paralleled improvement in physical function. Of particular interest is the finding that various Minnesota Multiphasic Personality Inventory (MMPI) scales that were initially clinically elevated showed a significant decrease to nonelevated levels after treatment. The clinical implications of these findings are discussed, along with the important observation that one should avoid assuming that a single psychologic test can reliably be used as the sole predictor variable in clinical cases.

Achievement↗

PubMedDate not supplied

Validation of questionnaires on physical function.

Data-gathering instruments were used in a randomized controlled trial, designed to assess a structured preoperative educational program for elective surgical patients. The key dependent variable was the physical functional capacity of patients following surgery. Questionnaires were developed to measure physical functioning in the immediate postoperative period, after discharge from hospital, and 10 days and 33 days after surgery. Statistical techniques used to measure interobserver agreement and bias were worker's chi square, Cicchett's statistic, the contingency coefficient, Kendall's Taub, and Kendall's coefficient of concordance W. The standardized questionnaires permitted classification of patients's postoperative physical functions with results that agreed highly with the classification done by experienced clinicians who cared for the same patients.

Activities of Daily Living↗

PubMed1991

Disease and psychosocial factors related to physical functioning in rheumatoid arthritis.

One hundred and fifty-five patients with rheumatoid arthritis (RA) were randomly selected from a tertiary care outpatient rheumatology clinic. Disease, treatment, psychosocial and demographic data were collected to test a biopsychosocial model of Physical Functioning as determined by the Arthritis Impact Measurement Scales (AIMS). Cross-sectional and longitudinal hierarchical and stepwise regression analysis were performed to identify variables associated with Physical Functioning. The results of the hierarchical regression revealed that only the disease and psychosocial sets of variables were significant. Stepwise regression revealed that Disease Severity (disease set) and Arthritis Helplessness (psychosocial set) accounted for 37% (longitudinal) to 60% (cross-sectional 12 months---greater than 12 months) of Physical Functioning variance. Our results suggest a role for the inclusion of psychosocial factors in studies of the development of physical disability in patients with RA.

Adult↗

PubMed1976

[The ageing-factors of several physical functions in man (author's transl)].

The ageing-factor is a measure for the rate of ageing. In the model of vitality the error rate mu corresponds to the ageing-factor. The ageing-factors of several physical functions can be determined from the ascent of decrease of these functions. The standardized ageing-factors of the considered physical functions range from 0,001 to 0,017 year-1 and are smaller than the ageing-factor of the whole organism. The date of the occurrence of pathological manifestations as a result of ageing-conditioned decrease of functions can be estimated by means of the ageing-factors.

Activities of Daily Living↗

PubMed1992

The accuracy of self and informant ratings of physical functional capacity in the elderly.

To compare the accuracy of self-ratings with informant-ratings of physical functional capacity in the elderly, 150 elderly patients attending a geriatric day hospital (GDH) and their formal and informal community carers were administered a questionnaire about their ability to perform activities of daily living (ADL). Direct observation of the patients' performance by therapists at the GDH was used as a standard, after the reliability and validity of this approach had been evaluated. Self-ratings were shown to be more accurate and less biased than informant-ratings, both for individual ADL and overall functional capacity. The accuracy of all ratings tended to be greater for less complex or physically demanding ADL, and informants tended to consistently underestimate functional capacity. The concurrent validity of the adapted Barthel Index in a self-report format was also demonstrated. Wherever possible, information concerning the physical functional capacity of an elderly subject should in the first instance be sought from the subject himself, as the quality of such information may be superior to that of his carers.

Activities of Daily Living↗

PubMed1986

Million Behavioral Health Inventory: its utility in predicting physical function in patients with low back pain.

The present study evaluated the use of psychologic measures, in particular, the relatively new Million Behavioral Health Inventory (MBHI), in predicting change in physical function of chronic low back pain patients undergoing a functional restoration program. The first 134 consecutive patients completing this program were assessed. Results demonstrated that various clinical scales of the MBHI were predictive of improvement in physical function. In addition, various scales enabled discrimination between patients who completed the program and those who prematurely dropped out. Although this inventory shows promise in helping to predict response to treatment, no single psychologic test can reliably be used as the sole predictor in clinical cases.

Adult↗

PubMed1990

Difficulties in physical functioning reported by middle-aged and elderly women with breast cancer: a case-control comparison.

Levels of physical functioning reported by women aged 55 to 84 with incident breast cancer were compared to those reported by women of the same age without the disease. A total of 422 breast cancer patients, identified through the Metropolitan Detroit Cancer Surveillance System, were interviewed 3 and 12 months after diagnosis. Interviews with 478 controls of the same age, identified through telephone random-digit dialing, were conducted twice during the same time period. At 3 months, patients aged 55-64 and 65-74 reported greater difficulty than controls in completing tasks requiring upper-body strength. Little difference was shown between cases and controls aged 75 to 84. After one year, patients aged 65-74 still reported higher than expected levels of difficulty in light lifting as well as pushing and lifting heavy objects. Among cases aged 55-64, only pushing and lifting heavy objects remained problematic. Estimates of the prevalence of physical difficulty will be useful in planning future breast cancer treatment and rehabilitation services.

Activities of Daily Living↗

PubMed1990

Hierarchical measures of physical function in ambulatory geriatrics.

Brief and uncomplicated methods for obtaining information on functional status would facilitate the assessment of older patients. We evaluated the potential usefulness, reliability, and validity of four hierarchical measures of physical function in 123 elderly subjects seen in four ambulatory geriatrics settings. Although the vast majority (83.2%) of subjects were fully independent on the Katz Activities of Daily Living Scale, a broader scope of functional difficulty was reported on the Spector-Katz, five-item OARS, and Rosow-Breslau scales. The three scales all had either borderline or more acceptable coefficients of scalability (0.57-0.77); the hierarchical order of items was not observed in 5.3% to 13.6% of subjects. Combining items from these established measures resulted in two new scales with acceptable scalability and construct validity; however, some errors in item order persisted. Although their ease of administration is clearly advantageous, clinicians using short hierarchical scales to assess functional status of older patients should be aware of their limitations.

Activities of Daily Living↗

PubMed1989

Years of life with good and poor mental and physical function in the elderly.

A population of Roman Catholic sisters (nuns) were divided into a high education group (i.e. at least a Bachelor's degree) and a low education group (i.e. less than a Bachelor's degree). Prevalence data on 132, 75-94 year old, sisters indicated that the high-educated had better mobility and hand coordination, stronger handgrip, better distant and near visual acuity, and fewer mental impairments than the low-educated group. Life table analyses on 154 sisters indicated that the high-educated lived an average of 3.28 years longer after age 75 than the low-educated. Years of life with relatively good and poor mental and physical function after age 75 were estimated by a mathematical model that used mortality and prevalence data. According to the model, high-educated sisters lived an average of 3.57 years longer with good function and 0.29 of a year less with poor function than low-educated sisters.

Activities of Daily Living↗

PubMed1988

Toxicity, physical function and everyday activity reported by patients with inoperable non-small cell lung cancer in a randomized trial (chemotherapy versus radiotherapy).

In a randomized trial, patients with inoperable non-small cell lung cancer with limited disease were randomly given either radiotherapy (42 Gy) or combination chemotherapy with cisplatin, 70 mg/m2, and etoposide, 100 mg/m2, given every third week with a maximum of 4 cycles. The patients were asked to fill in a questionnaire concerning psychosocial well-being, medical and treatment related symptoms, physical function and everyday activity. Of the chemotherapy patients 61% reported nausea 5 weeks after their last chemotherapy session and 44% had spells of vomiting. Only 14% of the radiotherapy patients had nausea and 5% vomited 14 weeks after start of treatment. Of the radiotherapy patients 64% experienced dysphagia compared to 8% of the chemotherapy patients 6 weeks after the start of treatment.

Carcinoma, Non-Small-Cell Lung↗

PubMed1978

Smoking, lung function, physical performance and latent coronary heart disease in presumably healthy middle-aged men.

During a cardiovascular survey comprising 2014 presumably healthy men aged 40-59 years, latent (previously undetected) coronary heart disease (CHD), lung function and physical performance were related to differences in smoking habits. The survey examination classified 1 832 individuals as "normals" (without clinical signs/symptoms of CHD). Among the others, a strong supicion of CHD was found in 115, of whom 105 had diagnostic coronary angiography. No angiography was performed in another 35 individuals with slight, albeit typical angina pectoris. The remaining 42 men were excluded from this presentation for various reasons. The following findings were obtained: 1) in the 69 men with positive coronary angiography, the extent of coronary atheromatosis was positively related to the number of cigarettes smoked. 2) The smoking habits of the 35 individuals with slight angina pectoris but no angiography did not differ from those of the "normals". 3) Physical performance during a near maximal bicycle exercise test and lung function according to spirometry were strongly and negatively related to smoking (in "normals"). 4) Previous smokers and never-smokers among "normals" had almost identical lung function and physical performance.

Adult↗