PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Physiologic age”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMedDate not supplied

[Nutrition and state of health of older persons during physiologic aging].

Features peculiar to actual nutritional pattern (in family) of persons of advanced and old age in physiological ageing were studied. According to a fairly broad range of characteristics (cardio-vascular function, blood coagulation system, lipids metabolism parameters, body weight, general clinical diagnosis, etc.) their health status was determined. The alimentation of the examined is shown to be characterized by marked individual peculiarities. On the whole it conforms to the existing recommendations, although there is noted a certain deficiency of proteins, vitamins and mineral elements. Differences in the nutrition of males and females were established. The calorific value of the nutrition declines parallel with the increasing age. Its comparison with the health characteristics of the examined testifies to the presence of a close relationship between them. More favourable indices of the bioelectric activity of the heart, myocardial contractility, the trends in the lipids metabolism, body weight, the blood clotting activity were registered in persons with reduced calorific value of the alimentation.

Aged↗
PubMed2026

Physiologic age modifies the association between visceral fat predominance and urinary calcium excretion in adults with nephrolithiasis.

Although adiposity is associated with kidney stone disease, the relationship between abdominal fat distribution and urinary calcium excretion remains unclear. We investigated whether the CT-derived visceral-to-subcutaneous fat ratio (VSR) was associated with 24-hour urinary calcium excretion and whether physiologic age modified this association. This retrospective cross-sectional study included 308 adults with nephrolithiasis who underwent preoperative CT, stone removal, and postoperative metabolic evaluation. Participants were stratified into prespecified younger (men aged&#x2009;<&#x2009;50 years and premenopausal women) and older (men aged&#x2009;&#x2265;&#x2009;50 years and postmenopausal women) physiologic-age groups. Multivariable linear regression assessed the association between VSR and urinary calcium excretion and its modification by physiologic age. Results showed that VSR was not associated with urinary calcium excretion in the overall cohort, but its association differed significantly by physiologic age (P for interaction&#x2009;<&#x2009;0.001). Among younger participants, each 1-unit higher VSR was associated with 2.07 mmol/day greater urinary calcium excretion (95% CI, 1.23-2.90), whereas no significant association was observed in the older group. These findings suggest that the metabolic relevance of visceral fat predominance differs by physiologic age, with a significant association observed only in younger adults. Prospective studies are needed to confirm these findings and determine their clinical implications.

Humans↗
PubMed1978

Cell cycle and the concept of physiological age with special reference to pyruvate kinase activity in WI-38 cells.

WI-38 cells were synchronized by mitotic collection and periodically assayed for pyruvate kinase activity. The kinetics of the synchronous cohort were determined by continuous labelling index and by mitotic index. The experimental data were analysed by computer using a state vector model to yield the probability density functions for phase transit times and for cell physiological ages. Pyruvate kinase activity for these cells as a function of physiological age was then examined using the computer model. Considering DNA synthesis, pyruvate kinase activity and mitosis to be markers of physiological age, it was found that a model which assumes that a cohort of synchronized cells desynchronizes irreversibly and uniformly from one age marker to the next is incompatible with the experimental data. For example, the times over which cells entered the S phase were too widely distributed to be consistent with the mitotic index data. Also, for pyruvate kinase activity to be a function of physiological age alone, the cell ages were probably too dispersed to be compatible with the experimental enzyme data. Alternative models for cell physiological ageing are presented, which are compatible with the experimental data.

Cell Cycle↗
PubMedDate not supplied

[Determination of the physiological age of female fleas by using a luminescence microscopy method].

On the basis of studies of age changes in the ovaries of Ct. orientalis, Ct. teres, C. laeviceps and X. conformis by means of luminescent microscopy a scale was plotted for identification of physiological age of females of fleas. Depending on the presence or absence of yellow bodies and on the stage of development of oocytes in the ovary the fleas are arranged into two main groups: breeding and non-breeding females. According to the total combination of characters, size and colour of yellow bodies, presence and character of luminescence in the germarium and adjoining areas of vitellarium, the presence of "starvation bodies", "degeneration bodies" and resorpting oocytes, the state of seminal receptable, each group is divided into subgroups that enables us to make a detail description of age composition of the population under study.

Aging↗
PubMed1978

Chronologic and physiologic age affect replicative life-span of fibroblasts from diabetic, prediabetic, and normal donors.

Cultured skin fibroblasts from subjects with clinically apparent diabetes mellitus and from subjects genetically predisposed to diabetes have a replicative lifespan that is inversely related to donor age. Fibroblasts from carefully defined normal subjects not predisposed to diabetes fail to show this correlation. The data support the idea that physiologic status of the tissue donor is a more precise determinant of fibroblast replicative lifespan than chronologic age.

Adolescent↗
PubMedDate not supplied

[Physiological age of the fleas and the analysis of age structure of natural population of Xenopsylla gerbilli Wagn].

A new six-graded scale is suggested instead of five-graded one proposed earlier (Kunitskaya, 1960). Analysis of the reproduction and age composition of the natural population of X. gerbilli with a use of the suggested scale enabled the authors to find out regularities in the reproduction, senescence and change of generations of these insects in South Pribalkhashke. It was established that one complete, one incomplete and possibly third partial generation develop in this region for a year.

Aging↗
PubMed1979

Physiological ageing of red blood cells and changes in membrane carbohydrates.

Evidence is presented to indicate a generalized role for the terminal sialic acid residues of circulating erythrocytes. After reinjection into their donors, neuraminidase-treated human, rabbit, rat and dog erythrocytes were promptly removed from the circulation : intect erythrocytes, previously incubated under the same conditions but without neuraminidase, were removed after a significantly longer period. The neuraminidase-treated erythrocytes were cleared by the liver and in a little part by the spleen. Old and young human, rabbit, rat erythrocytes contained different quantities of stromal sialic acid, significantly lowered on the old cells. But the half-life of old intact rabbit erythrocytes is sigificantly shorter than that of neuraminidase-treated young erythrocytes with a similar minidase-treated young erythrocytes with a similar sialic acid content. Indeed sialic acid is not the only carbohydrate component of the membrane that is decreased during erythrocyte ageing, the others membranous sugars are decreased too. Theses changes in the carbohydrate moity could have a role in the clearance of the erythrocytes.

Animals↗
PubMed1977

The influence of physiological age on the biting rhythm of Culex tritaeniorhynchus Giles (Diptera : Culcidae)

All of 704 Cx. tritaeniorhynchus females caught on bufflo bait were inseminated and 98 % were at ovariole stage 1. Parity rates ranged from 41 % to 66 % on the 4 nights studied with increases observed during dusk, midnight and before dawn. Changes in the parity of the biting population were related to sexual maturation, mating, oviposition rhythms and especially the survivorship of the adults.

Age Factors↗