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At least 19 recordsLinked to original sources
PubMed1977

Morphology of the placenta in fetal I-cell disease.

Placentas were studied from three interrupted pregnancies of a mother whose first liveborn child had I-cell disease (mucolipidosis II). I-cell disease of the fetus was shown by investigation of the amniotic fluid, fetal cells and the aborted fetus in two pregnancies, but in the third case placenta was the only available product of conception. In every placenta extensive vacuolization of the syncytiotrophoblastic layer of the chorionic villi and chorionic mesenchymal cells was found. In electron microscopy the inclusions were identical to those of other tissues in I-cell disease. The importance of histological study of placenta in unexplained spontaneous abortions needs to be emphasized, since this may be the only way of detecing new cases of lysosomal storage diseases.

Abortion, Habitual↗
PubMed1976

Correlation of ultrasonic and soft tissue xray placentography in 300 cases.

Three hundred cases in which both ultrasonic and soft tissue placentography examinations had been done are correlated with each other and the clinical findings. These are grouped in two series, one in 1972-1973 and the other 1973-1974. The accuracy rate for both methods was 95 per cent. Outright errors were 2 per cent, and cases in which correlation was lacking for reasons other than diagnostic errors were 3 per cent. Reasons for this lack of correlation are discussed and illustrated. Seven examples of the ascending (or migrating) placenta were also found and an illustrative case is described.

False Negative Reactions↗
PubMed1977

Extra-amniotic blood clot simulating placenta previa on ultrasound scan.

The ultrasonic appearance of extra-amniotic blood clot simulating placenta previa is presented. The single case presented is the most illustrative and best documented example of this phenomenon in a series of 10 patients. The ultrasonic characteristics of this phenomenon are discussed.

Adult↗
PubMed1976

The effect of maternal partial exchange transfusion on the infants of patients with sickle cell anemia.

The reproductive outcome of pregnancies complicated by severe sickle cell hemoglobinopathies is not usually satisfactory. In this study, prophylactic partial exchange transfusions have been used in 35 patients with sickle hemoglobinopathies. There was significant improvement in results, both maternal and neonatal, as compared to those in 29 pregnancies complicated by similar disease processes who did not receive this therapy. The former group was also compared to 61 normal pregnant patients and 31 patients with sickle cell trait, none of whom received blood as part of their therapy. The results were similar in the group receiving transfusions and in the group with sickle cell trait. There was a decrease in perinatal wastage, prematurity, and incidence of low-birth-weight infants in the transfusion group when compared to the patients with hemoglobinopathies who were treated conservatively.

Anemia, Sickle Cell↗
PubMed1976

[The accuracy of placental scintigraphy (author's transl)].

The results of 150 placental scans are reported, using 99mTc erythrocytes, 113mIn gelatine and 113mIn tranferrin. Accuracy was checked at surgery and compared with ultra sound findings. In 62% of patients, the indications for placental scintigraphy was suspicion of placenta praevia because of bleeding in late pregnancy. In 38% placental localisation was performed for amniocentesis for Rh incompatibility. Localisation of the placenta was accomplished in 98.6% by scanning and in 95% by ultra sound. Accuracy of scanning was 94% and ultra sound 70%. Placental scanning is at present the most accurate method for a placental localisation and should therefore be used when an accurate diagnosis cannot be achieved by other techniques.

Amniocentesis↗
PubMed1977

Urinary estriol for assessment of fetoplacental function.

A total of 1,607 urinary estriol determinations were performed in 447 patients with normal and complicated pregnancies. In general, the test provided reliable information concerning fetal status, particularly in pregnancies complicated by toxemia, diabetes, and postmaturity. When measured consecutively, a drop of 50% or more in estriol level usually should be considered a significant index of fetal distress. Limitations of the test and several compensatory measures aimed at minimizing inaccuracy are discussed.

Adolescent↗
PubMed1978

An electroimmuno-assay of the pregnancy-specific beta1-glycoprotein (SP1) in normal and pathological pregnancies, and its clinical value compared to human chorionic somato-mammotropin (HCS).

A 95% reference interval for the pregnancy-specific beta1-glycoprotein (SP1) was established on the basis of 299 samples from 254 normal pregnant women by electroimmuno-assay (rocket immunoelectrophoresis). A positive correlation was found between SP1 and the human chorionic somato-mammotropin (HCS). The SP1 concentration in maternal blood was halved about 30 hours after separation of the placenta at delivery. Thus emergency analyses would be of little value in detecting acute placentae failure. 172 determinations of SP1 in maternal sera were carried out on 56 pregnant women with various types of pathological pregnancies. To assess the clinical value of SP1 a comparison with HCS (HPL) was made. It was concluded that SP1 could possibly be a valuable parameter for monitoring and discovering pathological pregnancies. Larger investigations, however, must be performed to decide whether SP1 determinations will provide more extensive information than other laboratory analyses presently used.

Age Factors↗
PubMed1977

[A critical analysis of the present state of recognizing the fetal hazard in pregnancy, via hormonal determinations (author's transl)].

The experience published in medical literature on the pregnancy hormones HPL and estrogens, is subjected to a critical review. The reported studies are examined in detail, first of all, with regard to the performance of the pregnancy hormones in fetal risk situations, taking certain pregnancy complications into account. The ranking of these paremeters in arriving at obstetric decisions in fetal emergency situations, is then described. This is followed by an assessment of the importance of the pregnancy hormones as prognostic parameters for forecasting fetal hazard in cases where pregnancy appears to have taken an uneventful courese, basing on few results available to date. All findings indicate that biochemical monitoring during pregnancy contributes toward individualization of the obstetric decisions.

Estrogens↗
PubMed1979

[Maternal hemoglobin level and fetal and neonatal prognosis].

Maternal and feto-neonatal pathology in pregnant women with Hb values less than 10 gr./100 ml. in the last ten weeks of pregnancy was estimated. WHO considers HB values (gr./100 ml.) a valid and sufficient parameter for a clinical classification of the different degrees of anaemia in pregnancy: the authors agree with this suggestion.

Adult↗
PubMed1977

[The clinical significance of the oxytocin challenge test (author's transl)].

In order to test the function of fetoplacental unit 398 oxytocin challenge tests were performed on 280 patients who had exceeded the calculated date of delivery or where factors of risk were involved. 8% of the tests performed showed a positive result, 1% was suspect and 91% were negative. The figure of 20% of false-positive test results was relatively high compared to only 1.6% in the case of false-negative test results. In cases where the calculated date of delivery has been exceeded, pregnant women who showed a negative test result are kept under observation by us as out-patients, whilst patients whose oxytocin challenge test was positive are kept under close observation in hospital.

False Negative Reactions↗