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At least 19 recordsLinked to original sources
PubMed1978

The T1 vaccine used in the control of contagious bovine pleuropneumonia in Nigeria.

A lyophilised T1 vaccine was produced by direct lyophilisation of a 72-hour broth culture to which 10% sterile sucrose solution was added. Each vial contained 2 ml to make a total of 10 doses when reconstituted. Each ml of the product contained an average of 109 colony forming units of the organism. When injected at the tip of the tail or subcutaneously behind the shoulder of 2,000 zebu and 1,0000 Ndama cattle, no outward reactions were observed. 12 zebu cattle were vaccinated and challenged 6 months later by direct contact with artificially infected cattle for 4 months. All the animals were completely protected against the disease.

Animals↗
PubMed1975

Contagious bovine pleuropneumonia: mouse-protective antibody in the sera of infected and vaccinated cattle.

Cattle produced humoral mouse-protective antibody (MPA) to Mycoplasma mycoides var mycoides as a result of natural infection, hyperimmunisation, vaccination with well-known strains of living vaccines or vaccination with killed cultures. Bovine MPA was distinct from complement-fixing and precipitating antibodies and was frequently detected in their absence, particularly in the sera of vaccinated--as opposed to naturally infected--cattle. In view of its defensive role in artificially-infected mice, it seems likely that such antibody plays a part in resistance to the disease in cattle. High levels of MPA followed inoculation of cattle with killed concentrated culture containing adjuvant; this finding merits further investigation, as it may lead to improved methods of vaccination.

Animals↗
PubMed1976

Studies on the origin of false positive reactions to the complement-fixation test for contagious bovine pleuropneumonia.

Serums of cattle free from contagious bovine pleuropneumonia (CBPP) were tested in complement fixation (CF) tests using 3 antigens; these were the standard antigen (SA) used to test to CBPP in Australia, an ethanol extract antigen (EA) also prepared from Mycoplasma mycoides subsp. mycoides (M. mycoides) and an antigen prepared from a Group 7 bovine mycoplasma isolated from arthritis (AA). The serums included 146 which fixed complement with SA. Eighty percent of these false-positive serums reacted with AA but not with EA; the other 20% were positive at low titre with EA but gave no reaction with AA. Attempts were made to produce false-positive serums experimentally by inoculating 3 Group 7 mycoplasmas and 2 Mycoplasma bovigenitalium strains into cattle. Serums from 3 of 9 cattle inoculated with strain L2917 (Group 7) reacted with SA but differed from the false-positive serums of field cattle by reacting with all 3 antigens. Tests with serums from cattle experimentally infected with CBPP gave similar titres with SA and EA, but the results with AA were mostly negative or less than 10% of the titres obtained with SA and EA. The results of CF tests on serums from the experimental cattle, after absorptions with suspensions of the mycoplasmas, showed that there was a one-way serological relationship between strain L2917 and M. mycoides and between this Group 7 strain and M. bovigenitalium. The CF tests with 3 antigens have assisted in demonstrating the false-positive nature of the reacting field serums encountered in the course of routine CF tests for CBPP in cattle in Australia.

Absorption↗
PubMed1975

Passive immunity to contagious bovine pleuropneumonia.

A significant passive protection against contagious bovine pleuropneumonia (CBPP) was demonstrated in cattle. One group of cattle was inoculated with serum from CBPP-recovered cattle, while another group was inoculated with serum from susceptible cattle. The two groups, along with an untreated control group, were challenged with the virulent Gladysdale strain of Mycoplasma mycoides, using the in-contact method. Four out of the five cattle inoculated with serum from animals which had recovered from CBPP were protected, whereas three of five cattle inoculated with serum from susceptible animals and all the untreated animals died of CBPP.

Animals↗
PubMed1977

Investigations into the role of carrier animals in the spread of contagious bovine pleuropneumonia.

An attempt was made to transmit contagious bovine pleuropneumonia (CBPP) from 22 animals recovered from artificial infection to healthy animals. Despite close contact and the imposition of a number of stresses no disease was transmitted. An unsuccessful attempt was made to reactivate old CBPP lesions by corticosteroid treatment, and by splenectomy. Four animals recovered from artificial infection did not become reinfected when put in contact with acute disease. Seven animals were reinoculated with Mycoplasmamycoides sub-species mycoides by endobronchial intubation. No clinical disease resulted. It is concluded that sequestra do not break down easily and that it is difficult to reinfect recovered animals. It is suggested that in field outbreaks of obscure origin, investigation should be thorough before it is concluded that an animal with an old sequestrum was responsible.

Animal Diseases↗
PubMed1976

A mycoplasma from acute contagious caprine pleuropneumonia in Kenya.

A mycoplasma was isolated from acute caprine pleuropneumonia in Kenya. The organism could be differentiated serologically from the known strains of mycoplasma with which it was compared. When the organism was inoculated into goats it caused pleuropneumonia which was readily contagious, and from which the organism could be reisolated.

Animals↗