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At least 19 recordsLinked to original sources
PubMed1976

Complications of povidone-iodine absorption in topically treated burn patients.

One of the dangers of topical therapy in thermal injuries is absorption of the therapeutic agent with subsequent metabolic and toxic complications. Two patients, one 30 years old with a 75% burn, the second 72 years old with a 35% burn, were treated topically with povidone-iodine ("Betadine", pH 2.43). In both patients severe metabolic acidosis developed which could not be attributed to sepsis, hypovolaemia, renal failure, diabetes, lactic acidaemia, &c. The acidosis associated with the 75% burn required large amounts of sodium bicarbonate to maintain pH at 7.35 and a serum-bicarbonate concentration of 15 mmol/l (meq/l); serum-iodine was 48000 mug/dl (normal 4-8.5mug/dl). Acidosis in the second patient was not as severe, and serum-iodine concentration reached 17600 mug/dl. The rate of urinary excretion of iodine was 50.8 +/- 7.4 mg/dl and seemed to be fixed. Haemodialysis was very effective in reducing serum-iodine concentration. Povidone was also systemically absorbed. The persistent acidosis could be caused by absorption of the iodine or the acidic povidone-iodine. Until the aetiology of the acidosis and renal damage is more clear, iodophors should not be used topically for burns greater than 20% of the body surface or in the presence of renal failure.

Absorption↗
PubMed1977

Prevention of wound infection in abdominal operations by peroperative antibiotics or povidone-iodine. A controlled trial.

The wound-infection rate after abdominal operations was compared in 113 patients randomly allocated to an untreated control group, a group receiving preoperative lincomycin and tobramycin, or a group receiving local instillation of povidone-iodine. The wound-infection rate was 8.1% in 37 patients receiving antibiotics, 42.1% in 38 untreated controls, and 39.5% in 38 patients in the povidone-iodine group.

Abdomen↗
PubMed2026

Comparing the efficacy of chlorhexidine and povidone-iodine for surgical site disinfection: a systematic review and meta-analysis from randomized controlled trials.

BACKGROUND: Randomized controlled trials report conflicting evidence on the efficacy of different skin disinfectants for preventing surgical site infection (SSI). METHODS: We systematically searched PubMed, Web of Science, Cochrane Library, and Embase for RCTs published up to February 2025 comparing preoperative skin disinfection with povidone-iodine (PVI) versus chlorhexidine (CH). Primary outcomes were overall, superficial, deep, and organ/space SSI rates. Secondary outcomes included hospital stay, readmission, and reoperation. RESULTS: CH was superior to PVI in preventing overall SSI (26 studies, n = 29,356; RR: 0.89; 95% confidence interval [CI]: 0.80 to 0.99). The overall SSI incidence rate in the CH group was 7.1% (1,045/14,677), compared with 7.8% (1,152/14,679) in the PVI group, equating to an 11% reduction in relative risk and a 0.7% reduction in absolute risk. The number needed to treat to prevent one SSI was 143. CH demonstrated superiority over PVI in preventing superficial SSI (13 studies, n = 16,867; RR: 0.77; 95% CI: 0.64 to 0.92), but not for deep SSI (11 studies, n = 15,842; RR: 1.00; 95% CI: 0.77 to 1.29) or organ SSI (9 studies, n = 9,471; RR: 1.17; 95% CI: 0.89 to 1.53). No significant differences were found in hospital stay, readmission, or reoperation rates between the two groups. CONCLUSION: CH demonstrates statistical superiority over PVI in preventing overall and superficial SSI, though the absolute clinical benefit is modest. No significant differences were observed for deep or organ/space SSI, nor for secondary outcomes including hospital length of stay, readmission, or reoperation rates.

Humans↗
PubMed1979

[Local therapy of burns in childhood by tanning with povidone-iodine (author's transl)].

Since the end of 1974 we have used Betaisodona instead of Mercurochrome for Grob's three stage tanning because the harmful effects of the mercury contained in the Mercurochrome could not be excluded with certainty. The results were compared in 80 patients in each case. The two groups were comparable with regard to age, degree and extent of the burns. We obtained an equally firm and rapidly drying scab using Betaisodone as with Mercurochrome. Complete loosening of the scab took 16 days with Betaisodona and 14 days with Mercurochrome. Wound infection was no more frequent than with Mercurochrome disinfection.

Administration, Topical↗
PubMed1975

Gloved hand as applicator of antiseptic to operation sites.

A 95% ethanol solution containing 0-5% chlorhexidine digluconate caused a significantly greater mean reduction in skin bacteria (99-9% plus or minus 0-024) when rubbed by a gloved hand on to the skin of one hand for two minutes than when applied to the same area for the same time with the traditional gauze applicator for operation sites (90-7% plus or minus 2-12). The latter reduction, however, was greater than that reported in five previous experiments in which application of the same solution for the same time to two hands gave mean reductions varying from 79% to 84%. An aqueous solution and a 70% alcoholic solution of chlorhexidine also gave significantly greater reduction (and alcoholic povidone iodine almost significantly greater reduction) when applied by a gloved hand than on gauze. It is inferred that the effectiveness of skin disinfection depends both on the antiseptic used and on the manner of application, and varies with the amount of friction used in applying the antiseptic. Further studies on disinfection of the surgeon's hands with 0-5% chlorhexidine in 95% alcohol rubbed on and allowed to dry have supported its value and acceptability; the mean bacterial counts of washings from gloves of surgeons after operations were lower after the use of this method than after other preoperative preparations of the hands.

Bacteria↗
PubMed2026

Postpartum compositional changes in bovine calf nasal and dam vaginal microbiota and concurrent immune responses following prepartum betadine lavages.

As interest in bovine reproductive tract microbial communities increases, there remains limited information on how the insult of parturition influences postpartum dam reproductive microbiota and early-life microbial development. The objective of this study was to characterize postpartum changes in dam vaginal microbiota and neonatal calf nasal microbiota following transient prepartum disruption of the dam vaginal microbiota using betadine lavages (BLGs), and to evaluate concurrent systemic immune responses in dams and calves. Multiparous beef cows (n&#x2009;=&#x2009;12) were randomly assigned to either BLG (n&#x2009;=&#x2009;7) or control (CON; n&#x2009;=&#x2009;5) 3&#x2009;wk prior to the expected calving date, and dam vaginal swabs, calf nasal swabs, and blood were collected at 0 (+1), 15 (&#xb1;1), 30 (&#xb1;1), and 60 (&#xb1;1) d postpartum. Samples from Angus cow-calf pairs (n&#x2009;=&#x2009;12) underwent 16S rRNA gene sequencing with standard contamination controls and QIIME2 processing. Blood samples were analyzed using the D2Dx immunity assay to evaluate systemic humoral immune responses. Microbial alpha diversity (ANOVA), Bray-Curtis beta diversity (PERMANOVA), taxonomic composition (LEfSe), and D2Dx immune responses (repeated-measures mixed model) were analyzed (P&#x2009;<&#x2009;0.05). In calves, treatment influenced nasal alpha diversity at d 0 (P&#x2009;=&#x2009;0.03), while nasal beta diversity tended to differ at d 0 (P&#x2009;=&#x2009;0.08); however, treatment effects were not detected at d 15, 30, or 60 for alpha diversity (P&#x2009;&#x2265;&#x2009;0.76) or beta diversity (P&#x2009;&#x2265;&#x2009;0.14). Calf nasal communities shifted over time (P&#x2009;=&#x2009;0.001), with d 0 differing from d 15, 30, and 60, and beta diversity differing over time (P&#x2009;=&#x2009;0.006). In dams, BLG did not alter vaginal alpha diversity (P&#x2009;&#x2265;&#x2009;0.42) or beta diversity (P&#x2009;&#x2265;&#x2009;0.14) over time, and time did not affect vaginal alpha diversity (P&#x2009;=&#x2009;0.60) while vaginal beta diversity tended to shift over time (P&#x2009;=&#x2009;0.06). Postpartum dam vaginal and calf nasal communities differed compositionally regardless of time (P&#x2009;<&#x2009;0.05). Systemic immune responses, measured via D2Dx scores, fluctuated postpartum in dams (day effect: P&#x2009;<&#x2009;0.001) and calves (day effect: P&#x2009;<&#x2009;0.001), with BLG calves tending toward decreased immune response compared with CON (P&#x2009;=&#x2009;0.08). Prepartum BLG minimally influenced neonatal nasal microbial diversity at birth and did not alter postpartum dam vaginal community structure, while calf nasal microbiota and D2Dx immune responses changed markedly over the first 60&#x2009;d of life.

Animals↗