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At least 19 recordsLinked to original sources
PubMed1975

Application of powder failure testing equipment in assessing effect on glidants on flowability of cohesive pharmaceutical powders.

Powder failure testing equipment was used successfully to study the effect of glidants on the flowability of two cohesive pharmaceutical powders, lactose and calcium hydrogen phosphate, using the flow factor as the flowability parameter. Fine silica, magnesium stearate, and purified talc were investigated as glidants; for each host powder-glidant mixture, an optimum concentration of glidant was observed beyond which no further increase in flowability occurred. The order of efficiency of glidants for both host powders was fine silica greater than magnesium stearate greater than purified talc. The mode of action of the three glidants is discussed.

Calcium Phosphates↗
PubMed1978

[Microflora in milk powder and baby food in powder form (author's transl)].

After a discussion of the microbiological standards for milk powder and powdered baby food in various countries, the results of the microbiological analyses of some 1500 samples of these foodstuffs were presented. It emerged that the microflora of these products consists mainly of lactobacteria (they are not demonstrable with all culture methods), micrococci and bacilli: the latter are those with the greatest importance with respect to food hygiene. In addition to these Clostridia and moulds are also found in the samples; very occasionally enterobacteria are also found. No pathogenic germs were detected. With respect to the proposals for standards it was found that the latest Hungarian standards proposals are acceptable provided that the methods of analysis (culturing after Polonyi) are retained also for the proposals discussed.

Animals↗
PubMed1978

[Problems of the presence of potential mycotoxin producers in milk powders for babies (author's transl)].

Because of the finding of aflatoxin B1 in the liver of deceased children and in some samples of milk powder, commercial samples of domestic and foreign milk powder intended for babies were examined. From 4950 g of milk powder 11 119 colonies of 29 genera of mould were isolated, averaging 1,9 colonies for the domestic and 0,1 colonies/g for the foreign milk powders. The moulds were uniformly dispersed through the powder, but in one sample the greatest number of colonies was isolated from the surface layer of the powder in the original package. The results of the investigation must lead to a revision of views on the microbiological standards and the production and packaging technologies for baby foods.

Animals↗
PubMed1979

Long-term comparison of salbutamol powder with salbutamol aerosol in asthmatic out-patients.

Salbutamol dry powder was compared with salbutamol aerosol in 38 asthmatic patients. The study was double-blind and took place over six months. Salbutamol powder in a dose of 200 micrograms per capsule was able to control asthma as well as the aerosol, but some patients needed to increase the frequency of dosage when using the powder. The device used for powder administration, the Rotahaler, was well accepted and was preferred to the pressurized aerosol by one-third of patients. Dry powder administered by Rotahaler allows salbutamol to be given by inhalation to many patients previously using aerosols inefficiently.

Adult↗
PubMed1976

Physical properties of a nickel-base alloy prepared by isostatic pressing and sintering of the powdered metal.

The physical and mechanical properties of samples of a nickel-base alloy fabricated by powder metallurgy were determined. The particle sizes of the powders used to make the samples varied from -80/ +200 mesh to -325 mesh. The compaction pressure varied from 138 to 414 MN/m2 and the sintering temperature varied from 1150 to 1250 degrees C. The shrinkage during processing, the porosity, tensile strength, yield strength, elongation, and elastic modulus were used to characterize the samples. The strength of the samples generally increased with decreasing particle size of the powder and increasing compaction pressure and sintering temperatures. The porosity and strength, therefore, could be varied over a wide range by controlling the various parameters. The properties of the samples prepared by powder metallurgy were compared with those of the cast alloy and compact bone. Conditions can be selected that will yield equivalent or better properties by powder metallurgy than by casting.

Bone and Bones↗
PubMed1979

Detection of Salmonella in onion and garlic powders: collaborative study.

The relative efficiency of trypticase soy broth with added 0.5% K2SO3 and lactose broth as pre-enrichment media for recovering Salmonella from onion powder and garlic powder was collaboratively studied. For each spice, 13 collaborators each received 5 duplicate samples; 4 of the 5 replicate samples were inoculated with 1 of 4 levels of S. thompson ranging, at initiation of analysis, from greater than 3 to 93 organisms/g onion powder and greater than 3 to 43 organisms/g garlic powder. Salmonella growth was inhibited in each of these spices as evidenced by a rapid decline of most probable number values in samples determined immediately after and 7 days following inoculation. Collaborative results of cultural analyses demonstrated superiority of the modified tripticase soy broth for recovering Salmonella in each of the 2 spices. The improved method of detecting Salmonella in onion and garlic powders has been adopted as official first action.

Condiments↗
PubMed1976

Contact angles and wetting of pharmaceutical powders.

Contact angles of pharmaceutical powders were determined by the h-epsilon method, which consists essentially of measuring the maximum height of a drop of liquid fomed on a presaturated compact of the material. Determinations with aspirin as the test material indicate that the measured value is independent of the particle size of the powder and the porosity of the cake. The method was extended to include determinations on mixed powder systems. The results show that the hydrophobic material dominates with large particle-size powders; with small particle sizes, a linear relationship between the cosine of the contact angle of the mixed system and the proportion of the components is obtained. Results are presented for a wide variety of materials of pharmaceutical interest.

Aspirin↗