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At least 19 recordsLinked to original sources

Reduced dose of Rh immunoglobulin following first trimester pregnancy termination.

The efficacy and safety of a 50-microgram dose of Rh immune globulin for prevention of Rh isosensitization following first trimester vacuum abortion are evaluated in this study. A total of 1027 women undergoing abortion at three outpatient facilities participated in the study; 755 (73.5%) completed follow-up serologic screening 6 months after termination of pregnancy. None showed serologic evidence of Rh sensitization at the time of followup. No serious adverse reactions to the drug were observed.

Abortion, Induced

Statistical analysis of first-trimester pregnancy terminations in an ambulatory surgical center.

From June, 1973, to December, 1974, 12,219 women requested elective termination of pregnancy at the Concord Medical Center, a private outpatient clinic in Chicago, Illinois. Suction curettage with local anesthesia was performed for 10,890 of the women; the remaining 1,329 (10.9%) women were rejected for the following reasons: not pregnant, 1.9%; estimated duration of pregnancy over 12 weeks, 7.3% medical reasons, 1.6%; and other reasons, 0.1%. For the aborted patients, the immediate complication rate was 6.9 per 1,000. Complication rates were directly associated with length of gestation (whether determined on the basis of the patient-reported last menstrual period (LMP) or on the basis of the physical examination) and with the experience of the physicians. This study adds further evidence that first-trimester termination of pregnancy by suction curettage, with local anesthesia, in a nonhospital setting is a safe procedure when high medical standards are maintained.

Abortion, Legal

The use of silastic vaginal device containing (15S)-15 methyl prostaglandin F2 alpha methyl ester for early first trimester pregnancy termination.

(15 S) - 15 methyl prostaglandin F2 alpha methyl ester in a silastic vaginal device was administered to 9 gravid women in the first 7 weeks of gestation for elective termination of pregnancy. Continuous intrauterine pressure recording was carried out in one case. Prompt initiation of uterine activity and vaginal bleeding was seen and expulsion of products of conception occurred in under 24 hours in all cases. There were no serious complications and side effects were considered acceptable. Two patients have required subsequent curettage for removal of retained placental tissue. This incidence of failure to complete expulsion, if confirmed in a larger series, is considered to render this technique without modification unacceptable as a routine method for early pregnancy termination.

Abortion, Induced

First experiences with a (15S)-15-methyl prostaglandin F2alpha vaginal device for termination of early first trimester pregnancy with serial sonographic observations.

A silastic device containing 10 mg (15S)-15-Methyl Prostaglandin F2alpha was administered vaginally in three parous patients under 50 days gestation who requested therapeutic abortion. Painful contractions appeared within one hour and vaginal bleeding within three hours of application. All patients aborted, although in one tissue had to be removed from the uterus. Plasma progesterone concentrations were measured in two patients: they decreased within four hours, then increased slightly and finally decreased 24 hours after administration of the device. Nausea, vomiting, and diarrhea were observed in all three patients. The estimated blood loss was less than 100 ml and no significant hematocrit changes were observed in all patients. In serial sonographic examinations of one patient, the fragmentation and dislodgment of the gestational sac could be observed within six hours after administration of the device. After these albeit limited experiences, it is concluded that the (15S)-15-Methyl PGF2alpha vaginal device is of great potential value for induction of early first trimester abortion.

Abortion, Induced

Therapeutic abortion. The 1975 report from Ullevål Hospital.

The results from a prospective study of 1228 therapeutic abortions (the 1975 material) are reported. First trimester pregnancies (1028 cases) were terminated by suction and curettage and second trimester pregnancies by prostaglandins (200 cases). The overall follow-up (4-6 weeks after termination) was 94.3%. The incidence of perforation was 0.5% of the surgical terminations, none of which, however, resulted in any other complications. The mean incidence of re-admission was 3.9%, the main causes being retained products or pelvic infection. The mean incidence of pelvic infection (salpingitis/parametritis) was 1.6%. The highest incidence of pelvic infection was found in early pregnancies (less than 8 weeks) or nulliparous women (2.7%) and the lowest (1.5%) in the induction group.

Abortion, Therapeutic

Ectopic pregnancy and first trimester abortion.

A total of 41,753 first-trimester abortions were done over a 4-year period at two Planned Parenthood centers, among which 11 verified cases of ectopic (tubal) pregnancy were discovered. Elective abortion provides an opportunity for the diagnosis of unruptured ectopic pregnancy. Pathologic examination of tissue specimens is important in suggesting the presence of an ectopic gestation. Patients who become pregnant with an intrauterine device in place are at higher risk for an ectopic pregnancy.

Abortion, Legal

Active and inactive renin in pregnancy and in women on estrogen-containing oral contraceptives.

Total and active renin concentrations (TRC and ARC) were determined in pregnant women and in women on estrogen-containing oral contraceptives to study the variation of plasma renin forms in pregnancy. TRC was already elevated in the first trimester. After that TRC increased consistently reaching the maximum in the third trimester. The ratio of inactive renin concentrations (IRC) to TRC was between 20 and 30% throughout gestation. Therefore, it was supposed that the development of the placenta or the enlargement of the uterus do not affect the ratio of IRC to TRC too much. In women on oral contraceptives in whom plasma renin activity was increased due to elevation of renin substrate, the ratio of IRC to TRC was almost the same as that in normal controls. From these results, it was suggested that the development of the placenta and the enlargement of the uterus do not play an important role in the variation of plasma renin forms, although remarkable changes are observed in the renin substrate and total amounts of renin in pregnancy.

Adult

[Legal abortion during the first trimester of pregnancy at the University Hospital for Women in Novi Sad (1960-1975)].

The authors present the results of their own observations and investigations of legal abortions until the 12th week in the University Department of Gynaecologigy and Obstetrics of Novi Sad for the period 1960 to 1975. The analysis discusses success, failures and complications in 83,121 legal and 23,321 cases of other abortions registered in the Department in the mentioned period. In particular, injuries of the uterus at these interventions, haemorrhage after and during abortion and distinctly low mortality at legal abortions--1 case or 0.0012% are discussed.

Abortion, Therapeutic

The frequency of ovular resorption during the first trimester of twin pregnancy.

A follow-up of 78 twin pregnancies diagnosed in the first trimester indicated that early ovular resorption occurred in 63% of spontaneous and 64% of Clomiphene-induced gestations, so that singletons were born. No failure was observed in the 12 twin conceptions following administration of gonadotropins or Cyclofenil.

Chorionic Gonadotropin