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Results for “Promedol”

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At least 19 recordsLinked to original sources

PubMed1976

[Analysis of the effect of morphine and promedol on uptake and release of noradrenaline by myocardial tissue].

A study was made of the effect of morphine and promedol on the content, uptake, and release of norepinephrine (NE) on rat myocardium. Promedol proved to decrease the NE level in the myocardium. Morphine failed to influence the release of the NE-14C from the isolated perfused heart, whereas promedol increased it significantly, altering both the "slow" and the "rapid" release of the mediator. Promedol failed to influence the uptake of NE-14C by the perfused heart, whereas morphine decreased it significantly. The competition between morphine and NE was characterized by the effect of incomplete inhibition: morphine and NE produced reciprocal effects on the affinity of one another to the receptor, and their interaction depended on the ratio of the concentrations of these drugs.

Animals↗

PubMedDate not supplied

[Method of continuous intravenous postoperative analgesia with promedol in newborn children].

Continuous intravenous infusion of promedol, 0.1 mg/kg, with additional boluses, 0.5 mg/kg, was used as postoperative analgesia in 20 newborns. Fifteen (25%) children were operated for congenital gastrointestinal defects or peritonitis, 2 children (10%)--for chylothorax, and tumor was eradicated in 3 (15%) children. On the basis of behavioral reactions, physiological indices (cardiac rate, arterial pressure, SpO2, and respiration rate/artificial pulmonary ventilation--APL) as well as of laboratory "stress" tests (blood glucose and cortisol and acid-base balance) it was proven that analgesia with continuous intravenous promedol infusion was effective. It was shown as possible to administer the promedol infusion in newborns while switching them from APL to independent breathing until the spontaneous breathing with constant positive pressure is ensured provided the pO2, pCO2 and SpO2 respiration indices are satisfactory.

Analgesics, Opioid↗

PubMedDate not supplied

[Morphine and promedol interaction with the plasma proteins of allergized rabbits].

It has been established that morphine interacts with albumins, alpha 2- and beta-globulins, while promedol with all globulin fractions and to a less measure with plasma albumins of the intact rabbit. Interaction of morphine and especially that of promedol with the same protein fractions of allergizated animals proceeds more actively and is characterized by a more pronounced formation of biological complexes with alpha 1-globulins. Decreased pharmacological activity of morphine and promedol coincides with intensification of their interaction with proteins.

Analgesia↗

PubMedDate not supplied

[Comparative evaluation of the protective action of nalorphine and pentazocine in acute morphine and promedol poisoning].

It was shown in experiments on white rats that the intensity of the antitoxic action of nalorphine (0.57 mg/kg) and pentazocin (3 mg/kg) is related to the chemical structure of a narcotic analgetic agent. This action is more clearly manifested during poisoning induced by the phenylpiperidine derivative promedol (LD50 33.33 mg/kg). Nalorphine increases LD50 of promedol and corrects of metabolic disturbances produced by promedol. Pentazocin does not compare favourably to nalorphine since it mostly acts as a stimulant of external respiration.

Acid-Base Equilibrium↗

PubMedDate not supplied

[The effect of premedication using promedol and galanthamine on the course of epidural anesthesia with trimecaine].

The course of epidural anesthesia with a 2% trimecaine solution has been studied in 93 patients (mean age 56.5 years) upon premedication with promedol (20 mg) and galanthamine (10 mg). It has been established that promedol promotes mainly to a reduction in the time of anesthesia onset (by 26.5%) and to the enhancement of the antihypertensive reaction (by 15.7%). Premedication with galanthamine is accompanied by a 13% decrease in the initial anesthetic dose, a 34.5% shortening of the time of anesthesia onset and the attenuation of negative hemodynamic shifts. Upon premedication with both drugs, the total trimecaine expenditure decreases by 25% and the time of anesthesia onset shortens more than by half.

Adult↗

PubMedDate not supplied

[Changes in the pharmacodynamic properties of promedol, droperidol and dimedrol in burn shock and combined radiation-thermal injury].

Toxic and pharmacological properties of promedol, droperidol and dimedrol were studied during burn shock and combined radiation and thermal injury (CRTI). Acute toxicity and analgesic effect of promedol were shown to increase in the given period Droperidol analgesic effect enhanced in burn and CRTI, cataleptic action enhanced only in CRTI. A decrease of antihistaminic activity of dimedrol was more pronounced in CRTI.

Animals↗

PubMedDate not supplied

[Effect of morphine and promedol on oxygen metabolism in the skeletal muscles in various functional states].

It has been demonstrated in experiments on rats that in the skeletal muscle, morphine and promedol cause, during disconnection of efferent innervation with pavulon, a dose-dependent reduction in oxygen tension (OT) and an increase in the oxygen consumption rate constant (OCRC). During disconnection of the central mechanisms of muscle tone control with sodium thiopental, morphine and, to a greater degree, promedol decreased OT. The OCRC was markedly decreased under the effect of morphine in a dose of 25 mg/kg.

Animals↗

PubMedDate not supplied

[The status of central and peripheral hemodynamics at different stages of combined peridural anesthesia with lidocaine and promedol in children].

The results of studies of central and peripheral hemodynamics during surgery performed under combined epidural anesthesia with lidocaine and promedol are presented. The study was performed on 82 children with surgical pathology aged 3 to 14 years. The state of hemodynamics was assessed using integral body plethysmography suggested by M. I. Tishchenko. The results of the studies have shown that surgery performed under epidural anesthesia with lidocaine and promedol was associated with stabilization of basic central and peripheral hemodynamic parameters at baseline level, which indicates that there is an effective anesthesiological protection of a child's body from the operation trauma.

Adolescent↗

PubMedDate not supplied

[Analysis of the role of various factors of the initial status of the body in the analgesic action of promedol].

A comprehensive approach is suggested to the assessment of the analgetic action of analgetics during screening. This approach lies in the study of the drug effects on the emotional, vegetative and motor manifestations of the painful reactions. Based on multiple and regression analysis the role of different factors of the initial status of the body in the development of analgesia is demonstrated. Application of the given approach is examplified by the reference analgetic promedol.

Animals↗

PubMed1976

Stereochemical studies on medicinal agents. 20. Absolute configuration and analgetic potency alpha-promedol enantiomers. The role of the C-4 chiral center in conferring stereoselectivity in axial- and equatorial-phenyl prodine congeners.

Opical antipodes of the axial phenyl analgetic, alpha-promedol hydrochloride (3), were prepared and the absolute stereochemistry wasd determined by relating one of the enantiomers to its gamme diastereomer having the 2S, 4S,5R configuration. The analegetic potency of (+)-(2R,4S,5S)-3 is 20 times that of morphine, while its enantiomer, (-)-(2S,4R,5R)-3, is inactive at 50 mg/kg. These results are in accord with prior reports which indicate that substitution of a 3-or 5-alkyl group on the pro-4S enantiotopic edge of the piperidine ring leads to enantiomers which have greater potency than those substituted in an identical position on the pro-4R edge. This coupled with the fact that the torsion angle between the axial phenyl group and piperidine ring in (+)-3 is of the same sign as its equatorial congeners, suggests that the C(3)-C(4)-C(5) moiety and its substituents at C(4) are located in a similar chiral environment on the receptor. In contrast, the C(2)-N-C(6) portion of the axial and equatorial molecules does not bind in the same receptor environment, and it is suggested that different modes of interaction in the prodine series arise from different orientations of this moiety.

Analgesics↗

PubMedDate not supplied

[Effect of promedol and fentanyl on the permeability of the hemato-encephalic barrier of rats for noradrenaline-H3].

In tests situations with rats it was shown that promedol and phentanide produce an analgetic action accompanied by a reduced flow of tagged norepinephrine from the blood into the brain. A parallelism between the dosage of the substances and the intensity of the analgetic effect and the degree of changed permeability of the blood-cerebral barrier could be noted.

Animals↗

PubMed1976

[Comparative characteristics of the serotonin and histamine content in the blood of surgical patients before and after antibiotic administration against a background of droperidol, promedol and atropine premedication].

The effect of intramuscular administration of ceporin and megacillin in single doses of 500 mg and 1000000 Units respectively on serotonin and histamine blood levels in 34 patients against the background of premedication with droperidol, promedol or atropine was studied. The observations showed that after megacillin injection the serotonin blood levels decreased. Ceporin had no effect on serotonin and histamine blood levels.

Adolescent↗

PubMed1952