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Results for “Protein-Energy Malnutrition”

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At least 19 recordsLinked to original sources
PubMed1975

Serum-albumin as a prognostic indicator in oedematous malnutrition.

Examination of the records of 340 children admitted to hospital in Uganda with oedematous malnutrition (kwashiorkor) showed that the serum-albumin concentration at admission was closely related to mortality-rates. Furthermore, in this series, it was not possible to show a simple relation between mortality-rates and the degree of wasting present. The results further emphasise the need to include serum-albumin concentration in international classification systems for the assessment of protein-energy malnutrition, especially that of the kwashiorkor type.

Body Height↗
PubMed1979

Evaluation of urinary alkaline ribonuclease activity in the assessment of subclinical malnutrition in weanling rats.

The sensitivity of the hydroxyproline (OHP)/creatinine (Cr) index and the free urinary alkaline ribonuclease activity as indices of nutritional status have been compared using rats as an experimental model. The results have revealed that the OHP/Cr index is a better biochemical parameter than the urinary alkaline ribonuclease activity for indicating a subclinical degree of malnutrition.

Animals↗
PubMed1976

Etiological determinants of protein calorie undernutrition in a rural child community.

Two groups of randomly selected underweight and well-nourished preschool children residing in study villages of Punjab, Ludhiana district were examined with respect to their socioeconomic background, birth weights, dietary intakes, quality of received mother care, blood biochemistry, parasite load, psychomotor development and past illness prevalence. It was found that underweight children showed significantly less favourable indices in all of the above categories except stool parasitology suggesting an extremely intricate and complex interaction of a host of ecological variables in the causation of undernutrition. Using the discriminate analysis on readily available social variables, it was found that caste affiliation and, less so parental income were the two most significant variables distinguishing between the two groups. A model for the interaction patterns of ecological variables in their effect of protein calorie malnutrition for the given area is suggested.

Birth Weight↗
PubMed1979

Developmental protein malnutrition: influences on the central nervous system of the rat.

Our group has been carrying out interdisciplinary studies on the effects of prenatal and postnatal protein malnutrition on the developing rat brain. Anatomical, physiological, biochemical and behavioral approaches using the same animal model have revealed that protein malnutrition affects the brain at various levels, i.e., (1) anatomical, as revealed by Golgi findings of deranged dendritic trees on analysis of cortical and subcortical areas; (2) physiological, as revealed by delayed sleep pattern maturation, disturbances in seizure thresholds, slowing of sensory cortico-cortical and thalamocortical evoked potentials, and changed power in hippocampal theta activity; (3) biochemical, as revealed by marked increases in biogenic amines dating from birth, as well as modifications in tryptophan metabolism; and (4) behavioral, as revealed by various changes in responses to different kinds of aversive stimulation. Reversal studies have revealed that many changes are permanent and not amenable to nutritional rehabilitation even at birth, which is before the brain growth spurt in the rat. Our paradigm closely mimicks the human condition of low level, chronic protein undernutrition and thus reveals the underlying disturbances due to malnutrition. The dietary reversal studies are attempts at pin-pointing critical brain growth periods, beyond which recovery of functions is not possible.

Animals↗
PubMed1977

Reduced renal acid excretion in malnutrition: a result of phosphate depletion.

Eleven infants recovering from protein-calorie malnutrition secondary to acquired monosaccharide intolerance were found to have reduced plasma bicarbonate concentration associated with inadequate weight gain. Renal net acid excretion (NAE) was decreased to a mean of 34.2 micronEq/1.73m2/min. Titratable acidity (TA) was markedly reduced, accounting for only 16% of NAE. This marked reduction in TA was associated with reduced mean phosphate (PO4) excretion (.074 mg/min) and a reduced mean serum PO4 (3.9 mg/dl), suggesting PO4 depletion. Two patients received intravenous phosphate loads, resulting in an increase in mean NAE from 35.1 to 89.7 microgEq/1.73m2/min. A similar response was seen after oral PO4 supplementation. Three patients were studied after partial correction of their acidosis. At a relatively low plasma bicarbonate concentration (mean = 16.6 mmoles/liter) significant amounts of bicarbonate were detected in the urine (mean = 8.7 micronEq/1.73m2/min), suggesting a defect in bicarbonate reabsorption. Five patients studied after complete recovery from malnutrition had normal NAE in response to ammonium chloride load. The reduction in NAE appears to be secondary to unavailability of urinary buffers and a reduction in bicarbonate reabsorption; both of these defects can be explained by phosphate depletion.

Absorption↗
PubMed1975

Gastric pH and microflora of normal and diarrhoeic infants.

The microflora and pH of gastric contents were determined in breast-fed and in bottle-fed normal infants, in well nourished infants with acute diarrhoea and in infants with chronic diarrhoea and protein-calorie malnutrition. The last group of infants was reevaluated after recovery from diarrhoea and protein-calorie malnutrition. A bactericidal pH effect below 2-5 was observed. Bottle-fed controls had low pH values and low bacterial concentrations, whereas infants with chronic diarrhoea and protein-calorie malnutrition had high pH values and bacterial overgrowth, essentially of Gram-negative bacilli. After recovery, the only remaining alteration was the frequent isolation of yeast-like fungi in low concentrations. Infants with acute diarrhoea, except for the isolation more frequently of yeast-like fungi, presented no alterations; this seems to indicate that pH alterations and Gram-negative bacilli overgrowth occurred during the evolution of the disease to a chronic state. Breast-fed normal infants had hydrogen-ion concentrations similar to those of the chronic diarrhoea group, but without Gram-negative bacilli overgrowth, suggesting that other factors, besides pH, regulate bacterial growth in the gastric contents of these groups of infants.

Acute Disease↗
PubMedDate not supplied

Continuation of abdominal pregnancy complicated by preeclampsia three weeks after birth of an intrauterine twin.

A case of heterotopic pregnancy in a 22-year-old multigravida is presented. The extrauterine baby was delivered alive three weeks after the intrauterine pregnancy had ended at term in spite of an associated preeclampsia. The inhibition of lactation resulting from the continuation of the extrauterine pregnancy resulted in marasmus for the first baby. The implications and especially the etiology of preeclampsia occurring in extrauterine pregnancy are discussed.

Adult↗
PubMed1976

Signs, symptoms, and pathophysiology of Pneumocystis carinii pneumonitis.

In 80 patients with Pneumocystis pneumonitis, the intial signs and symptoms of infection were usually fever and cough, followed by tachypnea and coryza. Flaring of the nasal alae and cyanosis occurred later. Blood gas composition was markedly altered in its acid-base profile in most patients at admission. There was moderate to severe respiratory alkalosis and hypoxia. Clinical manifestations were correlated with the extent of histopathologic changes in the lung. (Deprivation of protein in the diet of rats provoked P. carinii infection.) P. carinii infection was found in children with kwashiorkor; evidence of protein-calorie malnutrition is closely associated with P. carinii pneumonitis in children wiht cancer and other primary diseases. P. carinii pneumonitis proved unique in that the causative organisms remained limited to the lungs even in fatal cases. No toxins have been identified, and systemic effects of the infection were only those that could be related to hypoxia and fever.

Adolescent↗
PubMed1977

[Practical problems and results of parenteral alimentation in 60 patients undergoing surgery for neoplasms of the esophagus].

Sixty patients suffering from a neoplasm of the oesophagus underwent surgery. All received parenteral alimentation in an intensive care unit and its value was studied, in particular in the immediate postoperative period. Describing the technique used, together with the qualitative and quantitative nature of the products employed, the authors analyse the results obtained and in particular the effectiveness of treatment from the standpoint of protein balance and of body weight stability in these patients.

Adult↗
PubMed1977

Disorders of phagocyte function: biochemical aspects.

Intensive laboratory investigation of patients with recurrent infections, and with infections with microbial species not usually considered to be pathogenic, have led to the identification of several defects in granulocyte function. The two functions of granulocytes which have received most attention in the past decade have been locomotion (especially response to chemotactic stimulation) and microbicidal activity. Defective granulocyte chemotaxis has been demonstrated in patients with clinical manifestations suggesting abnormalities related to vasoactive amines, i.e., patients with eczema and extreme IgE hyperimmunoglobulinemia. The depressed granulocyte chemotactic responsiveness found in these patients can be reproduced in vitro when histamine and beta adrenergic agents are incubated with control granulocytes. Since these compounds have been shown to increase levels of intracellular cyclic AMP in other cells, there appears to be an association between cyclic nucleotide metabolism and regulation of granulocyte locomotion. Defective granulocyte microbicidal activity is found in patients with chronic granulomatous disease and it has been shown that there is little increase in oxidative metabolism during phagocytosis by these cells. Methods for quantitating the oxidative metabolism of granulocytes and monocytes include oxygen uptake, reduction of nitroblue tetrazolium, formate oxidation, and chemiluminescence response during phagocytosis. Since products of oxygen metabolism, i.e., hydrogen peroxide, superoxide or singlet oxygen do not accumulate in granulocyte phagocytic vacuoles, intracellular microbes are not killed (except bacterial species that produce hydrogen peroxide). The biochemical basis for defective oxidative metabolism in granulocytes from patients with chronic granulomatous disease appears to be associated with abnormal nucleotide oxidase activity.

Blood Bactericidal Activity↗