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Results for “Pterygium”

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At least 19 recordsLinked to original sources

PubMed2026

Revealing the Association of LIG1 Genetic Variants With Pterygium Susceptibility and Demographic Characteristics in a Taiwanese Population.

BACKGROUND/AIM: Pterygium is a common ocular surface disorder associated with long-term ultraviolet exposure and/or oxidative DNA damage. Accumulated evidence suggests that defects in DNA repair pathways may contribute to pterygium risk. DNA ligase I (LIG1), a key enzyme involved in DNA replication and base excision repair, has been involved in the etiology of several human diseases, including cancers. However, its role in pterygium has never been examined before. This study aimed at exploring the association between the LIG1 genotypes and pterygium risk in a Taiwanese population. PATIENTS AND METHODS: The hospital-based case-control study was conducted including 165 patients with pterygium and 320 age- and sex-matched non-pterygium controls. LIG1 rs20579 genotypes were accessed utilizing polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology. Stratified analysis and the calculation of odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used for evaluating the associations between genotypes and pterygium risk. RESULTS: Individuals carrying the homozygous variant AA genotype exhibited a significantly elevated risk of pterygium compared with those carrying the GG genotype (OR=2.74, 95% CI=1.17-6.43, p=0.0305). Under the recessive model, the AA genotype conferred a 2.65-fold elevated risk (95% CI=1.14-6.18, p=0.0350). The variant A allele was also associated with increased susceptibility (OR=1.46, 95% CI=1.03-2.07, p=0.0413). Stratified analyses revealed significant associations specifically among individuals aged ≥60 years (OR=5.64, 95% CI=1.67-19.04, p=0.0039) and males (OR=5.23, 95% CI=1.74-15.73, p=0.0034), but not those of younger ages or females. CONCLUSION: The LIG1 rs20579 genotype is significantly associated with pterygium susceptibility in Taiwanese individuals, particularly among elderly and male subjects. These findings support the involvement of impaired DNA repair machinery in pterygium pathogenesis and suggest that LIG1 rs20579 may serve as a novel genetic biomarker for risk assessment and early detection of pterygium.

Humans↗

PubMed1992

Pterygium excision using 193-nm excimer laser smoothing and topical mitomycin C.

A total of 31 eyes with primary pterygium and 24 eyes with recurrent pterygium underwent surgical treatment and were followed for at least 1 year. The surgery involved a conventional bare-sclera technique combined with excimer laser smoothing of the wound bed. Postoperatively, the eyes were medically treated with topical mitomycin C (0.02%) for 4 days and with steroids for several weeks. No recurrence was noted within the 1st year in the primary pterygium group, whereas recurrence was observed in 3/24 eyes that had been treated for recurrent pterygium, equivalent to a recurrence rate of 12.5% in this subgroup. Nine eyes (16.4%) had gained 2 lines or more in visual acuity by 1 year after surgery. Granuloma developed in 3 eyes, and dellen formation was detected in 1 eye after surgery. The combination of surgical management with local mitomycin therapy may be considered to be a safe and effective technique for the removal of pterygium. Although the visual results were good, the role of excimer laser smoothing in the treatment of this disorder needs further investigation.

Female↗

PubMed1977

The management of pterygium.

A rationale for the management of pterygium, based on theory and clinical experience, is presented in this review. Pterygium is classified as primary, secondary (recurrent), or pseudopterygium. Empirical data and proposed theories of pterygium pathogenesis and recurrence are discussed. The treatment of pterygium based on this information is divided into four phases: diagnosis, medical therapy, surgery, and postoperative adjunctive measures. The indications, techniques, results, and complications of the postoperative adjunctive measures used to lower recurrence are considered. Guidelines for the treatment of pterygium are recommended.

Administration, Topical↗

PubMed1979

Prevalence of pinguecula in Greenland and in Copenhagen, and its relation to pterygium and spheroid degeneration.

The prevalence of pinguecula has been studied by slit lamp examination of 659 Eskimos in South Greenland and 810 Caucasians in Copenhagen. The overall prevalence was found to be 56 per cent in Greenland against 41 per cent in Copenhagen (P less than 0.001) and to rise with increasing age, though with a fall after the age of 60 among Greenland women. Pingueculae (measured by their vertical height) are largest among Greenlanders, and larger in males than in females. They increase in size with increasing age. They are generally located nasally in Greenlanders and temporally in Copenhageners. The prevalence of pinguecula in almost 1 1/2 times higher among Greenlanders than among Copenhageners, while that of spheroid degeneration and that of pterygium are 3 times and slightly over 10 times higher respectively. The incidence of pinguecula and spheroid degeneration are correlated per site and per subject in the two geographically different series. Pterygium is not correlated with regard to site, this being always located nasally. Pterygium practically never harbours spheroid degeneration, neither in its body nor in its head (81 pterygia). Pinguecula and pterygium are therefore to be regarded as two different disorders, while spheroid degeneration is related to pinguecula.

Adolescent↗

PubMed1975

The clinical significance of a single unilateral temporal pterygium.

A rare case of a single temporal pterygium is reported. The etiology of pterygium and its predilection for the nasal side is discussed. A hypothesis is presented to explain why a pterygium never extends beyond the center of the cornea. Whenever a single temporal pterygium is noted it should be excised to determine the true nature of the lesion.

Humans↗

PubMed2025

Autologous Fibrin Glue in Pterygium Surgery as an Alternative to Commercial Fibrin Glue.

PURPOSE: The aim of this study was to evaluate the efficacy and safety of autologous fibrin glue in pterygium surgery, comparing it with commercial fibrin glue in terms of postoperative complications, graft stability, and recurrence rate. METHODS: A prospective, randomized, double-blind study was conducted, involving 42 patients with primary pterygium who underwent autologous conjunctival-limbal transplantation. The graft was fixed using autologous fibrin glue (Group 1, G1) or commercial fibrin glue (Group 2, G2). All patients underwent surgery performed by the same surgeon and were reevaluated on postoperative days 7, 30, 90, and 180 by an independent observer, assessing clinical parameters in the preoperative, intraoperative, and postoperative periods. RESULTS: No cases of severe adverse events were reported. Complete graft dehiscence occurred in 1 patient from G1. The G2 group had more cases of subconjunctival hemorrhage ( P = 0.0355). Pyogenic granuloma was observed in 1 patient from G2 and 2 patients from G1. There was no significant difference in recurrence rates between the groups (15% in G1 vs. 5% in G2; P = 0.2918). In both groups, graft dimensions tended to decrease slightly in the early postoperative period, followed by stabilization. CONCLUSIONS: Autologous fibrin glue demonstrated efficacy and safety comparable to commercial fibrin glue, making it a viable alternative to conjunctival graft fixation in primary pterygium surgery.

Humans↗

PubMed1975

[Ultrastructural studies on the pterygium. I. Epithelium and glands of the conjunctival part (author's transl)].

13 pterygia from patients aged between 39 and 81 years are studied by electron microscopy. The pterygium is covered by a multilayered, highly differentiated cylindrocellular epithelium. Arrangement and height of the microvilli of the superficial epithelial cells differ from those of the conjunctival epithelium. Morphological signs of secretion and resorption are found. As a characteristic the basal epithelial cells of the pterygium are rich in metaplasmatic filaments. Tubular glands are localised underneath the covering epithelium; they may reach the deep substantia propria. Their walls consist of a single layer of cylindrical cells. A varying number of goblet-cells are embedded between them. The secretion by the epithelial formations of the pterygium is of the merocrine, holocrine and microapocrine type.

Adult↗

PubMed1992

Serious complications of topical mitomycin-C after pterygium surgery.

BACKGROUND: The use of topical mitomycin (mitomycin-C) as a medical adjunct to pterygium and glaucoma surgery is increasing. METHODS: The authors report on a series of 10 patients who experienced serious, vision-threatening complications associated with the use of this drug after pterygium surgery. RESULTS: Complications included severe secondary glaucoma (4 patients), corneal edema (3 patients), corneal perforation (1 patient), corectopia (2 patients), iritis (8 patients), sudden onset mature cataract (2 patients), scleral calcification (1 patient) and incapacitating photophobia and pain (8 patients). Two patients required penetrating keratoplasties and a third required three lamellar keratoplasties. Another patient underwent four additional surgeries including a conjunctival Z-plasty, scleral patch grafting, and conjunctival autografting before his intractable pain and photophobia resolved 15 months after the original surgery. Because of these complications, 6 patients required a total of 20 return visits to the operating room after their original pterygium surgery. In 5 eyes, visual acuity remained at 20/200 or less. Three of the six patients with the most severe complications had concomitant chronic external diseases (rosacea [3 patients], ichthyosis [1 patient], keratitis sicca [1 patient]). CONCLUSION: The authors urge extreme caution in the use of mitomycin. If mitomycin is used, the lowest possible concentration should be applied for the shortest time period in an effort to avoid these complications. A prospective multicenter study of the ophthalmic use of this medication is needed.

Adult↗

PubMed1977

Is the occurrence of a temporal pterygium really so rare?

The author, in keeping with the data quoted in literature, confirms that a temporal pterygium is rare. Out of 1,388 Arab patients with pterygia, only 33 (2.4%) had temporal pterygia. The other statement, i.e. that temporal pterygium rarely occurs without a nasal one, is also confirmed. This was found only in one case (0.08%) out of the total number of people afflicted by pterygium.

Female↗

PubMed1976

Popliteal pterygium syndrome in a 74-year-old woman.

The case of a 74-year-old woman with the rare popliteal pterygium syndrome is presented. This syndrome is inherited as an autosomal dominant trait with incomplete penetrance and varying expression and consists of cleft lip and palate, lip pits, genital anomalies, popliteal pterygium, and malformations of the extremities. The various treatments our patient underwent over the years are reported. Treatment of popliteal pterygium involves special problems whem removing the skin fold because the nerve and vascular cords lie immediately anterior to the posterior fibrous cord. In the present case there are widespread arthrotic changes, both in the extremity joints and in the spine. These patients are short in stature. This, together with the general arthropathy, suggests a hereditary metabolic disturbance in the cartilaginous tissue.

Abnormalities, Multiple↗

PubMed1976

[Vitamin A and carotene concentration in serum in persons with chronic conjunctivitis and pterygium].

In 41 persons with chronic conjunctivitis, 28 persons with pterygium and 61 eye-healthy persons the Vitamin A and carotene blood level have been examined. All persons with chronic conjunctivitis and pterygium have subjective eye disturbances. In persons with chronic conjunctivitis the vitamin A blood level was lower (men 32 mcg%, women 20 mcg%). In almost all persons with chronic conjunctivitis and pterygium delayed dark adaptation was recorded and the skin-mucosal changes are more frequent.

Carotenoids↗

PubMed1992

Sclerokeratoplasty in recurrent pterygium.

There are many methods for the treatment of recurrent pterygium, and lamellar keratoplasty seems to be the most effective of them. A new method has been developed for the surgical treatment of recurrent pterygium. The most important steps in the procedure are: total removal of the cicatrix and then covering the bare corneoscleral surface with a single piece of corneoscleral tissue taken from a cadaver bulb. The operation was carried out in 11 cases. The follow-up period varied from 10 months to 4 years, the average being 28.7 months. No recurrences were observed. Pseudopterygium developed following the ninth removal of the recurring pterygium; however, even 2 years after the operation, it did not reach the area of the pupil.

Corneal Transplantation↗

PubMed1978

A hypothesis on the pathogenesis of pterygiums.

All true pterygiums are attracted to a specific site at the corneoscleral junction along the 3 to 9 o'clock meridian. The pathogenesis of a pinguecula-pterygium is postulated to be due to a noninfected inflammation at the junction of the conjunctival blood vessels and Bowman's membrane where the autolytic process of inflammation results in a protein degradation amino acid mixture which has the ability of attracting conjunctival blood vessels on the cornea. This amino acid mix is hypothesized to contain a pterygium angiogenesis factor.

Aged↗

PubMed1979

Experience with the avulsion technique in pterygium surgery.

A technique for pterygium removal is described which combines the avulsion of the pterygium head off the corneal surface with a precise isolation and resection of the pterygium. The conjunctiva is resutured to allow the sclera to remain bare. B-radiation in 3 divided doses is administered in each case.

Humans↗

PubMed1976

Lamellar keratoplasty for recurrent pterygium.

Lamellar corneoscleral keratoplasty technique for recurrent pterygium is described. The importance of accurate placement of the graft and its usefulness as a tissue barrier to regrowth of the pterygium is postulated. In fifteen eyes with severe recurrent pterygium followed from six months to four years, there have been no further recurrences after using this technique.

Adult↗

PubMed1977

[Results of lamellar keratoplasty for recurring pterygium (author's transl)].

Although difficult, recurrent forms of pterygium are seldom seen in central Europe, they cause considerable therapeutic problems because they cannot be cured by simple dissection and conjunctivoplasty. A useful method of treatment in these cases is the marginal, lamellar keratoplasty, which, according to the type of involvement, can take the shape of a sector, ring, horseshoe, or semicircle. If the pterygium is extensive and affects the center of the cornea, a subtotal, lamellar keratoplasty can be performed. The rate of recurrence in the group of 35 lamellar keratoplasties which we performed amounted to a satisfactory 31%. Only rarely did a pronounced astigmatism cause a decrease in the visual acuity postoperatively. Essential for the success of the procedures are exact surgical techniques and local use of atropine and cortison postoperatively. Just as with other surgical procedures, however, the lamellar keratoplasty cannot be considered the perfect method for all pterygiums.

Astigmatism↗

PubMed1975

[Ultrastructural studies on the pterygium. II. Connective tissue, vessels and nerves of the conjunctival part (author's transl)].

The stromal part of the pterygium is remarkably rich in plasma cells. The connective intercellular substance shows two different pathological modifications: A clotting together of collagen fibres to broad, osmiophilic, elastoid bands and a widening of the spaces containing the granular nonfibrillar ground-substance . The vascular system consists mostly of fenestrated sinusoid capillaries. Their endothelial cells frequently show degenerative changes and the basement membrane of the vessels can be as thick as up to 50--100 fold the normal size. For the first time nervous formations could be found in the pterygium. Axons of the autonomic system join the basal epithelial cells, where they form terminal endings. Encapsulated myelinated and nonmyelinated corpusles probably stem from the sensory nervous system.

Adult↗

PubMed1992

Pterygium treatment with triethylene thiophosphoramide.

In this study 146 pterygia were excised from 116 patients. The eyes were treated with Thiotepa eyedrops over four weeks to discourage regrowth. All treatment was carried out by the one surgeon on consecutive patients. The relationship between pinguecula and pterygium is explored, and the pathogenesis of pterygium growth discussed.

Adolescent↗