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At least 19 recordsLinked to original sources
PubMed1978

Relaxin-dependent adenosine 6',5'-monophosphate concentration changes in the mouse pubic symphysis.

The amount of cAMP in the pubic symphyses of estrogen-primed mice increases after injection of the hormone relaxin. This relaxin-induced increase in symphyseal cAMP was observed in immature, mature, and ovariectomized mature mice and could be prevented by prior ip injection of rabbit antibodies to porcine relaxin or by treatment of relaxin with dithiothreitol. The highest level of cAMP was measured 30 min after relaxin injection; the level of measurable cMAP then diminished rapidly. Estrogen-priming of the mice was not a prerequisite for a relaxin-induced response to occur. Relaxin administration did not increase the level of cAMP in a non-target tissue such as liver, nor could an increase in cAMP in the pubic symphysis be elicited by injection of insulin, a protein of similar size and structure, or glucagon, a known stimulator of liver cAMP levels.

Animals↗
PubMed1979

A comparative radiological study of the pubic symphysis in rheumatic disorders.

Radiological abnormalities are often seen at the pubic symphysis in rheumatic disorders. In a radiological study of 120 patients with rheumatic diseases osteitis pubis with erosive and sclerotic changes was a feature of ankylosing spondylitis. Irregularity and subluxation were not related to osteitis pubis or diagnostic group but were common in females and had a possible association with previous pregnancy.

Adult↗
PubMed1977

Effect of hormones on collagen metabolism and collagenase activity in the pubic symphysis ligament of the guinea pig.

The ligament which forms between the pubic bones of the pregnant guinea pig offers a unique system for the study of hormonal regulation of connective tissue metabolism. During the 5 days prior to parturition the length and hydroxyproline content of the pubic symphysis increase threefold. In nonpregnant animals, ligament growth can be induced in an estrogen-primed animal only following the administration of the hormone relaxin. A further increase in length can be achieved when progesterone is also injected. Removal and culture of post-partum ligaments, which undergo a 75% reduction in length and hydroxyproline content by the fifth post-partum day, allowed the demonstration of high collagenase levels released into the media. In contrast, when ligaments from pre-partum period were cultured, low levels of collagenase were detected in the media. The rapid post-partum ligament resorption could be partially inhibited if estrogen was injected immediately following parturition, whereas progesterone or relaxin significantly impaired ligament resorption. In a corresponding fashion, when the collagenase levels of these ligaments were measured progesterone treatment was shown to inhibit collagenase activity markedly while estrogen was less effective. Relaxin however, appeared to have no direct inhibitory effect.

Animals↗
PubMed1978

Symphyseal and sacroiliac joint pain associated with pubic symphysis instability.

Fifty patients presenting with lumbosacral and inguinal pain were examined by routine clinical radiographic and electromyographic evaluations. All were without antecedent history of major pelvic trauma or spinal surgery but demonstrated evidence of pubic symphysis instability. Slip between the pubic rami in excess of 2 mm could be demonstrated in each with alternate leg weight bearing. Asymmetry of hip mobility on the symptomatic side with a reduction in abduction and external rotation was present in 20 patients. An approach to treatment of pain associated with pubic symphyseal and associated sacroiliac joint instability is described, combining both intraarticular steroids, lumbosacral supports and physical therapy modalities.

Adolescent↗
PubMed1978

Estimation of age from the pubic symphysis by means of multiple regression analysis.

This study has been carried out to assess the age from the pubic symphysial surface employing a multiple regression analysis and a quantification theory model I analysis. Using partial regression coefficients and/or normalized scores obtained from the analyses, ages of skeletal remains can be quantitatively estimated with a fairly high reliability. The use of this method is, however, limited to the samples between 18 and 38 years of age, because age changes in the symphysial surface show large variations after about 40 years. The reliability of this method was also examined.

Adolescent↗
PubMed1975

[Multiplication of the different varieties of cells of the mouse pubic symphysis during growth and early gestation: radioautographic study with the use of tritiated thymidine].

1) A radioautographic study was undertaken after injection of tritiated thymidine during post-natal growth. The mitotic activity was localized in the three constituents of the mouse pubic symphysis: - in the osteogenic cartilage, labelled nuclei are numerous throughout animal growth; - in the articular cartilage, labelled nuclei are seldom encountered; - in the medial region, the chondroblasts, elongated dorso-ventrally, and the fibroblasts of the dorsal ligament show numerous labelled nuclei. 2. During the first pregnancy, the mitotic activity of the three constituents were examined separately: - in the osteogenic cartilage, the number of labelled cells increases at the beginning of the first pregnancy : the tibia epiphyseal cartilage apparently simultaneously shows revival of mitotic activity. After the 15th day of pregnancy, the osteogenic cartilage disappears by endochondral ossification; - in the articular cartilage and fibrocartilage, no mitotic activity is detectable as long as their typical characteristics are conserved. However, mititic activity becomes evident again when these cartilaginous cells cease to be surrounded by the typical chondroid matrix and become incorporated into the ligament. Cell multiplication therefore participated in symphyseal ligament dilatation.

Animals↗
PubMed1975

Age changes in the pubic symphysis of Macaca mulatta.

Age changes in the pubic symphyses of 142 Cayo Santiago rhesus monkeys (known age, sex and maternal genealogy) are described. Symphyseal development is sexually dimorphic. Males generate a ridge and furrow system which is gradually replaced by a solid ankylosis at the mid-sagittal plane. Female development parallels that of the male until puberty. With pregnancy and delivery, relaxation and reaggregation of pelvic ligaments binding the symphysis destroy the symphyseal face. Continued bearing of offspring inhibits mid-sagittal ankylosis. Limited estimates of skeletal age can be made by using symphyseal development as an indicator of senescence.

Age Determination by Skeleton↗
PubMed1977

Osteomyelitis of the pubic symphysis after urologic surgery.

Osteomyelitis represents a pyogenic infection of the bone and marrow. The diagnosis is based on specific criteria and often is difficult to make. Herein we present 2 cases initially thought to represent osteitis pubis but subsequently proved to be osteomyelitis and compare the 2 entities with emphasis on differential diagnosis and treatment. Despite certain differentiating characteristics the correct diagnosis is often uncertain without histologic examination. Since the treatment of these 2 entities is quite different equivocal cases should undergo surgical exploration and bone curettage. This procedure will enable definite diagnosis to be made and proper treatment to be instituted.

Curettage↗
PubMed1978

A re-examination of parturition scars on the human female pelvis.

Pits, cavities and depressions located on the dorsal surface of the pubic symphysis of females have been attributed to the trauma of parturition. Earlier research based on human skeletal remains provides inadequate information on the individual's obstetrical history. The 68 female pubic bones that were studied had comprehensive medical records indicating whether or not each female had given birth. Fourteen and one-half percent of the females who had not given birth exhibited trace to small scarring of the pubic symphysis and 23.4% of the females who had not given birth exhibited medium to large scarring. It is suggested that bony changes previously used as an indicator of child bearing must be re-examined in light of the fact that "birth scarring" has been found in women known not to have had children.

Female↗
PubMed1976

[Fine structure of the public symphysis in the mouse].

Classical histological descriptions of the modifications of the mouse pubic symphysis (PS) during pregnancy did not take sufficient account of its structural heterogeneity. Precise morphological study of the PS, in adult male and virgin female mice, was carried out under light and electronic microscopy. Our observations on pregnant females are still imcomplete. Two regions of the PS should be distinguished according to their structure and evolution during pregnancy. The cranial region shows diarthrodial articular characteristics. This region disappears in the female during the first pregnancy and is not reconstituted after parturition. The caudal region comprises two types of cells in the female : typical chondrocytes and a peculiar cell-type whose function has yet to be defined. The latter seems to be responsible for the loose structure of the symphyseal cartilage and to contribute to the development of pseudocavities in the ligament in the final days of pregnancy. It is possible that such cells may be stimulated by relaxin and may secrete a hydrophilic factor such as hyaluronic acid.

Animals↗
PubMed1977

The transpubic approach for strictures of the posterior urethra superior to the urogenital diaphragm.

For strictures of the posterior urethra lying superior to the urogenital diaphragm, a transpubic approach with resection of the pubic symphysis has been employed. This has permitted primary excision of the scar with reanastomosis of the urethra, thus correcting the defect in a single operation without the introduction of hair-bearing skin and with preservation of the external urethral sphincter. The results in five cases have been most gratifying.

Humans↗
PubMed1978

Relaxin bioactivity and immunoactivity in human corpora lutea.

Relaxin-like activity in extracts of corpora lutea (CL) from pregnant and non-pregnant women was determined by radioimmunoassay and by guinea pig pubic symphysis palpation assay. The biologically determined activity paralled the immunoactivity of extracts of CL of pregnancy. The relaxin content of CL of non-pregnant women was too low for detection by the bioassay.

Animals↗