Mammalian bites of children; a problem in accident prevention.
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This paper reviews recent experimental evidence in support of inoculation with antirabies serum, the value of which, as a prophylactic measure, is compared with that of vaccine treatment alone. The author concludes that the chief advantages of combined antiserum-vaccine prophylaxis lie in the rapid treatment of cases who have suffered severe exposure, and in the possibility of reducing the incidence of post-vaccinal complications.
The records of antirabies treatment given under the auspices of the Pasteur Institute of Southern India, Coonoor, to 412,800 persons between 1907 and 1951 are analysed. The results of treatment with dried-cord, Högyes, and 1%, 2%, and 5% Semple vaccines are assessed, taking into consideration the various factors in their preparation. An account is given of an enquiry which has been in progress since 1946 into comparative mortality among untreated bitten persons and those treated with 5% Semple vaccine.
TREATMENT BY THE CLASSIC METHODS OF PERSONS BITTEN BY RABID WOLVES GIVES RESULTS, BUT THESE RESULTS ARE UNSATISFACTORY: the case-fatality-rate is decreased, but only to an inadequate extent. New and more effective methods are indisputably required.
In an attempt to throw light upon the etiology of neuroparalytic accidents following antirabies treatment in man, the author analyses the process and effects of experimentally induced allergic encephalitis in various animals. He concludes that the two conditions are apparently identical, and suggests that the solution to the problem of neuroparalytic complications be sought in either the elimination of the encephalitogenic factor or the use of an antirabies vaccine which does not contain brain tissue.
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