SEARCH · PubMed Health
Results for “RH FACTORS”
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.
[Investigations on the determination of Rh factors & incomplete Rh antibodies with the papain method].
Explore the source record for details and available documents.
[Blood groups and factors in Yugoslavia; Rh factor in 30,000 erythrocyte samples].
Explore the source record for details and available documents.
Rh factors related to the Rho factor as a source of clinical problems; diagrammatic representation of their reactions and prediction of still undiscovered Rh factors.
Explore the source record for details and available documents.
[Rh factor sensitization; importance of the Rh antibody titer in the prognosis of the Rh-negative sensitized pregnant].
Explore the source record for details and available documents.
The rare blood factor rh (") or Eu.
Explore the source record for details and available documents.
Prevention of iso-immunization to the Rh factor using high titer anti-Rh gamma-globulin.
Explore the source record for details and available documents.
[The circumstances and background of the discovery of the Rh-factors].
We can hardly meet references in the literature to the various circumstances and factors that played an important role in scientific discoveries, although interesting conclusions could be driven from them. So, e.g., in the case of Landsteiner it is sure, that his idea, to investigate the reason of the mechanism and of the formation of a phenomenon, came from the phenomenon itself: namely, from the agglutination called forth by the fortuitous mixing of the cadavers' blood in the dissecting room. The present paper deals with certain circumstances that played a role in the discovery of the Rh-Factors, resulting not only scientific, but practical consequences as well. The data used here were collected primarily from the memoirs of professors Wiener, Levine, Dahr and from those of Speiser (Vienna). The authors were helped in their research also by their personal contact with professor Dahr (Cologne) established in the sixties. Landsteiner was compelled to emigrate from Austria mainly by the vivid anti-Semitism of the early 20s. Supposedly, without his emigration the Rh Factors would have been discovered much later. Working in the Rockefeller Institute (New York) Landsteiner was provided with everything that was needed for his research. He had organised a team and, helped by his colleagues, he succeeded to open a new field in immunserology. Unfortunately, before he could have completed his scientific project, he had died--already as a Nobel-Prize winner--in 1943. His project was resumed by his colleagues. The method of Rh-examination, exceeding the field of medicine, quickly won a greater significance, in anthropology, genetics and in biology. It is worth to mention, that Landsteiner, had already indicated shortly after his discovery the fields, on which the Rh-examinations later played a significant role.
Modulation of endothelial cell inflammatory integrins and stress markers with rh-factor VIIa in patients with advanced chronic hepatitis C.
Individuals with chronic hepatitis C (CHC) progress to cirrhosis and hepatic cancer. Individuals with advanced CHC are coagulopathic and can manifest fibrinolysis. The coagulopathy is a consequence of hepatocytic dysfunction. The fibrinolysis represents a response to local endothelial cell injury, and is of a low-grade. Based upon this hypothesis, the effect of the infusion of recombinant human factor VIIa (rh-FVIIa) on endothelial cell inflammatory integrins and measures of endothelial stress were determined in 17 individuals with advanced CHC. Immediately prior to the infusion of rh-FVIIa, the plasma levels of tissue factor (TF), Thrombomodulin (TM), human soluble ICAM-1 (hs-ICAM-1), human soluble VCAM-1 (hs-VCAM-1), human soluble L-Selectin (hs-L-Selectin), the prothrombin time and the activated partial thromboplastin time were determined. The same parameters were assayed at 5, 10, 30, 120, 240 and 360 min after infusion. TF and TM levels were very high at baseline consistent with a vascular endothelial stress response. Similarly hs-ICAM-1, hs-VCAM-1 as well as L-Selectin levels were increased. Thirty minutes after the infusion, a marked reduction in ICAM-1 and VCAM-1 and to a lesser degree L-Selectin levels was observed. This reduction persisted for 360 min. No change in measures of fibrinolysis [plasminogen activator inhibitor-1 (PAI-1), total tissue factor pathway inhibitor (t-TFPI), activated tissue factor pathway inhibitor (TFPIa), d-dimers (DD), FSP and fibrinogen levels] occurred. In addition, no change in plasma Annexin-V was observed. Based upon these data it can be concluded that: (1) rh-FVIIa corrects the coagulopathy seen in advanced CHC; (2) reduces endothelial cell injury and/or stress as evidenced by the TF, TM, hs-ICAM-1 and hs-VCAM-1 levels in plasma; (3) these changes in coagulation occurred without inducing a propagated vascular thrombosis.
Effect of recombinant human granulocyte colony-stimulating factor (rh G-CSF) on murine resistance against Listeria monocytogenes.
Recombinant human granulocyte colony-stimulating factor (rh G-CSF) enhanced resistance of mice against Listeria monocytogenes (LM) as determined by survival and bacterial growth. Mice pretreated with rh G-CSF twice daily for 5 days survived better than untreated animals to the challenge with LM. Number of bacteria in peritoneal cavity (PC) and spleen was lower in treated mice than that in the control group. Rh G-CSF increased mainly polymorphonuclear cells (PMN) in blood and spleen. After LM inoculation, a larger number of PMN and monocyte-macrophages accumulated in PC and spleen of tested mice. In addition, PMN primed in vivo with rh G-CSF released more superoxide anions when stimulated with phorbol myristate acetate. The inhibition of bacterial growth in PC and spleen could be ascribed to the accumulation of phagocytic cells at the infection sites and the increased oxidative metabolism. The results provided further evidence of the important contribution of G-CSF and neutrophils, as target cells, to the host defence against the intracellular bacteria.
Treatment of drug-induced agranulocytosis with recombinant granulocyte colony-stimulating factor (rh G-CSF).
Five patients with drug-induced agranulocytosis received 300 micrograms recombinant human granulocyte colony-stimulating factor (rh G-CSF) subcutaneously twice daily for 2-5 days. G-CSF therapy resulted in a steep increase of the neutrophil count, which was faster than that in patients with spontaneous recovery reported in the literature. In all four patients with infectious complications fever rapidly declined with the increase of granulocytes. G-CSF may be useful in the management of drug-induced agranulocytosis.
[Prevention of serological conflict due to Rh factor incompatibility by administration of domestic anti-Rh (D) immunoglobulin].
Explore the source record for details and available documents.
Distribution of the ABO system and Rh factor in Sardinia.
The authors examine the genetic structure of the Sardinian population based on the gene frequencies of the ABO blood group system and the Rh factor. The sample, composed of 13,972 individuals, is subdivided on the basis of altitude zones (mountain, internal hills, coastal hills and plains) and by historical-geographic zones. Also examined are the frequencies of a group of communities of different altitude and historical-geographic zones. The results point to genetic heterogeneity within both altitude and historical-geographic zones as well as within the single communities. A distribution gradient is seen for the IA and I0 alleles of the ABO system, namely: mountains, internal hills, coastal hills, plains.
Effect of recombinant human granulocyte colony-stimulating factor (rh G-CSF) on rat bone: inhibition of bone formation at the endosteal surface of vertebra and tibia.
The effect of recombinant human granulocyte colony-stimulating factor (rh G-CSF) on bone was evaluated by histomorphometry using Sprague-Dawley rats. rh G-CSF was injected at doses of 0, 50, 150, and 450 microg/kg for 6 weeks. In vivo double fluorochrome labeling was performed before sacrifice. No significant change in body weight was observed. Bone mineral density (BMD) of lumbar vertebrae and femora was significantly decreased in G-CSF-treated groups. In the lumbar vertebra, osteoid surface, osteoid thickness, trabecular thickness, and labeled surface in G-CSF-treated groups were also significantly lower. In addition, osteoclast number and osteoclast surface were significantly higher in the G-CSF-treated groups. The endocortical surface at the mid-tibia showed lower labeled surface and mineral apposition rate in G-CSF-treated groups, without significant changes at the periosteal surface. Furthermore, numerous granulocytes fully occupied the bone marrow area. We conclude that proliferating granulocytes in the bone marrow may inhibit bone-forming cells from contacting the bone surface, resulting in reduction of bone formation; and increased osteoclastic bone resorption induced by G-CSF treatment contributed to the reduction of BMD.
Recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) regulates f Met-Leu-Phe receptors on human neutrophils.
The regulation of mature human neutrophil function by recombinant human granulocyte-macrophage colony-stimulating factor (rH GM-CSF) was studied. Preincubation of neutrophils with this CSF did not stimulate superoxide anion directly but enhanced the subsequent release of superoxide anion in response to stimulation with the bacterial product formylmethionylleucyl-phenylalanine (f Met-Leu-Phe). Enhanced superoxide anion production was evident by 5 min and reached a plateau at 30 min. In contrast, neutrophils preincubated with rH GM-CSF exhibited reduced chemotaxis under agarose in response to a gradient of f Met-Leu-Phe. The inhibition of neutrophil migration was dependent on the dose of rH GM-CSF and exhibited a time-course similar to the effect on superoxide production. Binding studies of f Met-Leu-[3H]Phe to purified human neutrophils revealed heterogeneous binding to unstimulated cells. Two affinity components were identified. The high-affinity component consisted of approximately 2000 sites/cell and had an average Kd of 4 +/- 2 nM (n = 6). The low-affinity component consisted of approximately 40,000 sites/cell and had an average Kd of 220 +/- 130 nM (n = 6). rH GM-CSF caused conversion to a linear Scatchard plot showing no significant change in total binding sites but a single Kd of 30 +/- 10 nM. These data indicate that rH GM-CSF may influence neutrophil responses to f Met-Leu-Phe by regulating the affinity of f Met-Leu-Phe receptors.
[Distribution of ABO blood groups and incidence of Rh factor (D) in various ethnic groups in the Hindu Kush region (Kafirs, Kalash Chitrali)].
With the aid of Eldon cards the distribution of the ABO blood groups and of the Rh factor (D) was investigated in different native ethnic groups (Kafirs, Kalash, Chitrali) in the Hindu Kush region of Afghanistan and Pakistan. All studied groups are characterized by a relatively high frequency of blood group gene A and extremely low frequencies of B and O. This distribution differs appreciably from that of the rest of the Indian subcontinent as well as that of the adjacent Central Asiatic areas. The possible causes of the exceptional position of the native Hindu Kush groups in the ABO blood group system are discussed. It may be assumed that selection as a result of mother-child compatibility played a role as will be shown in a later paper. Concerning the studied traits of the Rhesus system, all investigated groups fit in the range of variation of the South Asian area.