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At least 19 recordsLinked to original sources
PubMed1961

Rifomycin. XIV. Production of rifomycin B.

The production of a fraction of the rifomycin complex (rifomycin B) by Streptomyces mediterranei has been described. Both qualitative and quantitative aspects of the fermentation are determined by suitable agitation-aeration parameters. In addition to conventional nutrient ingredients, the presence of some of the barbituric acid derivatives was found to be essential for rifomycin B production. An attempt was made to explain the mode of action of these compounds.

Anti-Bacterial Agents↗
PubMed1961

Rifomycin. XIII. Fermentation and production of rifomycin complex.

Rifomycin complex, a mixture of at least five different antibiotic principles, has been produced by submerged fermentation procedures in the laboratory and on pilot plant scale, using a semisynthetic medium. Difficulties were met with, due to the heterogeneity of the antibiotic principles. Mutation work led to the isolation of a strain that produced fractions C and D in greater amounts.

Anti-Bacterial Agents↗