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At least 19 recordsLinked to original sources
PubMed1975

[Criteria for choice of therapeutic procedures in lymphomas].

Surgery, high-energy radiotherapy and cyclic polychemotherapy are best indicated for the treatment of Hodgkin's disease and other forms of lymphoma. Overall evaluation will determine the most suitable management in each case. Clinical andpathological stage, the histological picture, the degree of vascular invasion and the immunological reactivity of the patient are the most important factors in such an evaluation. Close cooperation between the haematologist, histologist, radiologist, surgeon, radiotherapist, pharmacologist and immunologist will obviously be required.

Antineoplastic Agents↗
PubMed1976

Enhanced pulmonary toxicity with bleomycin and radiotherapy in oat cell lung cancer.

In a recently completed study, combination chemotherapy consisting of bleomycin, adriamycin, cyclophosphamide, and vincristine was given to 29 patients with oat cell lung cancer. There were no cases of pulmonary fibrosis in these 29 patients. Although several of these patients had prior radiotherapy, none had concomitant radiotherapy and chemotherapy. This same four-drug chemotherapy regimen was combined with concomitant radiotherapy in 13 patients with oat cell lung cancer. There were three cases of fatal pulmonary fibrosis and two other cases of clinically significant pulmonary fibrosis. All five cases of pulmonary fibrosis occurred several weeks after completion of a six-week course of bleomycin (total dosage 90 units). It is concluded that bleomycin cannot be safely administered while patients are receiving radiotherapy to the lung.

Bleomycin↗
PubMed1975

The effects of fast neutrons on inoperable carcinoma of the stomach.

Thirty-nine unselected patients suffering from inoperable, recurrent, or residual adenocarcinoma of the stomach were referred for palliation with fast neutrons from the Medical Research Council's cyclotron at Hammersmith Hospital. A full course of 1440 rads given in 12 treatments over 26 days was administered to the patients. Because of the relatively low energy (7-5 MeV) of the beam from this particular machine, it was not possible to deliver the full dose uniformly throughout the tumour except in extremely thin patients. Pain, dysphagia, vomiting, and bleeding were relieved in the majority of cases. The side effects were minimal and easily controlled. Palpable masses disappeared. Five patients required surgery after neutron therapy. All the incisions were made through irradioated tissue and all except one healed normally. Tumour was present outside the treated area, but the absence of any palpable mass within the treated area was a consistent finding. Radiologically, the stomachs remained abnormal and later changes included gross mucosal abnormality and shrinkage. Fourteen patients came to necropsy and in 10 no tumour was present macroscopocally. Tumour cells were seen in all except two cases but these were few, surrounded by dense fibrous tissue, and may not have been viable. The remaining stomach was abnormal with a thickened wall and destruction of mucosa. Three of the four cases in which macroscopic tumour was present received less than the standard dose because of the inadequate penetration of the beam. Excellent regression of tumors was achieved by the neutrons, but the stomachs did not recover from this satisfactorily. Gastrectomy four to six months after treatment is therefore suggested. This operation and other surgical procedures in other patients were successfully carried out. There is a need for higher energy neutrons to improve treatment and extend it to patients of thick-set build.

Adenocarcinoma↗
PubMed1975

Alveolar rhabdomyosarcoma of the ethmoid sinus.

A case of the alveolar rhabdomyosarcoma originating in the left ethmoid sinus was reported. Despite treatment by radical excision of the tumor, irradiation and chemotherapy, the patient died of generalized metastases of the tumor six months after surgery; however, no local recurrence of the tumor was found at an autopsy. The tumor was further studied by light and electron microscopic procedures.

Adult↗
PubMed1975

Radiation therapy of the liver metastatic disease.

Eight patients with symptomatic liver metastasis from different primary tumours received palliative radiation therapy. Daily doses of 150-200 r calculated in the mid-liver plane were delivered. The total dose employed was 2,500 r given in 3 weeks. Six patients responded good, one reasonable and one patient failed to respond to radiation. Liver function tests and liver scans also reflected the treatment response. All eight patients tolerated the treatment and no mortality due to treatment was recorded.

Adenocarcinoma↗
PubMed1975

[Semi-deep radiotherapy under high-kilovoltage conditions].

The semi-deep radiotherapy, performed by high-kilovoltage technique, fills a gap between superficial and megavolttherapy, as it renders possible an irradiation in focal depth of 2--4 cm, while largely preserving the deep underlying tissue. Besides which, every form of radiotherapy can be used, as under conventinal conditions. A further advantage exists in the markedly greater skin tolerance and in the low bone absorption of high-kilovoltage radiation, so that much higher focal doses can be achieved. This means that--in superficial processes--the high-voltage technique can replace the much more expensive therapy with accelerated electrons. The RT 305 equipment for high-voltage technique can be especially recommended for the following indications: 1. Skin and limph node metastases as well as tumors and metastases which are not situated deeper than 5 cm below the skin surface. Hereby, thean be exposed up to 8000 R, by small or medium cone. At the same time, in comparison to conventional X-ray therapy, the deep tissue is largely preserved. 2. Postoperative radiotherapy of tumors situated right under the skin. 3. Radiotherapy of inoperable breast cancer. 4. Irradiation of relapses on pre-exposed skin. 5. We assume that the high-voltage technique is also suitable for primary radiotherapy of larynx carcinomas, although we have no personal experience of this. 6. The palliative irradiation of deep tumors with the RT 305, due to its preservation of the skin and the relatively low bone absorption, can be performed more easily than with conventional X-ray therapy. The method of choice, however, is the megavolt-therapy. 7. Degenerative diseases and arthroses.

Adult↗
PubMed1975

[Indications for radiotherapy in gastrointestinal tumors].

As a pre- or postoperative measure, radiotherapy can contribute to the treatment of many gastrointestinal malignancies. Postoperative radiotherapy is recommended in malignant lymphoma of the stomach and the intestine, as well as for invasive and totally resected carcinoma of the recto-sigmoid in order to prevent local recurrences. Preoperative radiotherapy can be attempted for carcinoma of the lower third of the esophagus and extended carcinoma of the stomach and the rectum, as long as no better therapeutic association is available. Finally, curative radiotherapy can be administered for squamous cell carcinoma of the esophagus and the anus, with a reasonable chance of success, to avoid subjecting the patient to major surgery.

Adenocarcinoma↗
PubMed1975

[Radiotherapy of brain metastases].

Experiences are reported obtained with radiation therapy of brain metastases in 121 patients during the last 15 years. The treatment to lesser extent aimed at prolongation of survival but much more at the attempt to alleviate troubles and to spare pain. The indication thus involved medical points of view as well as ethical ones. The radiotherapy of cerebral metastases comprises the whole cranial volume and requires a focal dose of minimally 4000 R within four weeks. In 53% of the patients, the regression of neurological symptoms was considerable, in 18% even complete, partly beginning already after a few days of treatment. The number of recurrences was small. Under conditions of rigorous indication, the radiation therapy of brain metastases offers a rewarding palliative measure.

Adrenal Cortex Hormones↗
PubMed1976

Carcinoma of the esophagus. Long-term results.

Between 1940 and 1967, we treated 609 patients with primary carcinoma of the esophagus by three different methods. In the first group of 170 patients, surgical resection predominated. In the next 166 patients, radiation therapy was used as the primary method. In a third group (135 patients) and a fourth group (138 patients), radiation therapy was followed by resection in the operable cases. After comparing the results of the three methods, we believe that radiation therapy followed by resection produces the best results. Moreover, this approach is justified by the discovery of residual carcinoma in most surgical specimens from patients who have had radiation therapy.

Carcinoma, Squamous Cell↗