PubMed Health⌕ Search

SEARCH · PubMed Health

Results for “Refractive Surgical Procedures”

Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 19 recordsLinked to original sources
PubMed2005

[Corneal wound healing response following different modalities of refractive surgical procedures].

The corneal wound healing response following refractive procedures represents a subject of high relevance, due to its direct influence on the postoperative results. Technical modifications of current refractive procedures, like the automated flap creation with the femtosecond laser, LASEK, PRK with mitomycin C and Epi-LASIK have been proposed as alternatives to traditional LASIK and PRK. Several theoretical advantages have encouraged the diffusion of these new techniques; however, a better understanding of the corneal wound healing response following these procedures is required. The present text proposes a review of the corneal wound healing characteristics following different modalities of refractive surgical procedures.

Corneal Surgery, Laser↗
PubMed2005

Long-term histopathologic findings in human corneal wounds after refractive surgical procedures.

OBJECTIVE: To describe the human corneal histopathology after laser in situ keratomileusis, photorefractive keratectomy, astigmatic keratoplasty, clear corneal refractive lens surgery, conductive keratoplasty, and intrastromal corneal ring segment placement. DESIGN: Retrospective histopathologic study and selected literature review. METHODS: Ninety-four postmortem corneas from 49 patients and 10 corneal button specimens from 6 patients with previous refractive surgery were collected from eye banks and refractive surgeons in North America. This observational case series evaluated the pathologic findings in the wounds of these corneas in the context of previous studies. RESULTS: Three histopathologic types of corneal wound-healing responses were present in corneas after refractive surgery. The first was an epithelial cell modification that reestablished a smooth anterior corneal surface through basal epithelial cell hypertrophy, by epithelial hyperplasia, or both. The second was the production of a hypercellular fibrotic stromal scar, and the third was the production of a hypocellular primitive stromal scar. Although only the hypercellular fibrotic stromal scar could be identified on gross examination, all three wound responses were identified with light, electron, and immunofluorescence microscopy. Confocal microscopy also identified these three processes but with less detail and resolution. CONCLUSION: Understanding the locations, clinical appearance, and functional attributes of these wound-healing responses will help guide evolving techniques or adjunctive treatments.

Cornea↗
PubMedDate not supplied

Surgical procedures performed after refractive surgery.

BACKGROUND: Refractive surgical procedures have been performed for over one decade. The complications that cause visual disability are abnormalities in wound healing, residual ametropia, and/or severe irregular astigmatism. Many of these complications can be manifested clinically in terms of visually disabling problems (loss of best-corrected vision, glare, monocular diplopia, etc). Some of these complications require additional standard ophthalmic or refractive surgical procedures to restore vision. However, since these secondary procedures have been performed in only a few cases, we known little about their outcome. METHODS: We report the histopathologic analysis of 132 cases that have undergone a secondary surgical procedure following a primary keratorefractive procedure. We attempt to correlate the problems encountered with such secondary intervention with histopathologic information obtained from specimens that have been submitted to our pathology laboratory and that had undergone secondary surgical procedures. RESULTS: Many specimens displayed abnormalities in wound healing associated with visual difficulties such as loss of best corrected acuity, glare, and under- and overcorrection. A short time from the initial procedure to the time of secondary intervention was common. CONCLUSIONS: The combination of a secondary surgical or keratorefractive procedure can produce unpredictable refractive results. Judicious application of a refractive procedure and an appropriate time period before a second procedure is performed may reduce unexpected refractive complications.

Adult↗
PubMed2002

Ultrafast (femtosecond) laser refractive surgery.

Lasers with ultrafast pulses have been developed to decrease the energy necessary to incise tissues and to decrease damage to surrounding tissues. The IntraLase femtosecond (10-15 seconds) laser has been approved by the FDA for lamellar corneal surgery. It uses an infrared (1053 nm) scanning pulse focused to 3 microm with an accuracy of 1 microm to cut a spiral pattern in the corneal stroma creating precise lamellar flaps for LASIK. Clinical studies show that the flaps are uniformly of good quality with no flap complications. The flexibility of this system allows for intrastromal corneal surgery and may make it useful for other refractive and corneal procedures.

Animals↗
PubMedDate not supplied

Refractive surgery: an overview.

The status of refractive surgery is a dynamic and exciting field in ophthalmology. Current procedures are effective, safe and well tolerated. The future of refractive surgery continues to evolve, developing new and exhilarating forms of refractive correction. It remains to be seen which procedure will prove the most successful overall; or perhaps a variety of procedures will ultimately be the solution to the many facets of individual patient needs and desires.

Cornea↗
PubMed2001

[Cataract and refractive surgery in Hungary at the turn of the Millennium].

A survey of cataract-, and refractive surgery carried out around the Millennium presents the habits, styles and results of the Hungarian surgeons. There is a significant trend for transition to phacoemulsification procedure, 38 per cent of all cataract surgeries have been carried out with this most modern procedure, and 4/5 of the operating institutes possesses the equipment needed for this operation. The refractive surgeries in Hungary have been carried out in 11 private institutes. The number of these procedures are in close relation with the level of living standards.

Cataract Extraction↗
PubMed2004

The required technology for customized corneal ablation.

The introduction of wavefront sensing technology and customized corneal ablation has revolutionized the field of refractive surgery. Yet, in order for customized laser vision correction to reach its full potential, a number of technological requirements must be addressed by the specific laser vision correction platform offering this customized procedure. At present,several different technology platforms exist. A more thorough understanding of these platforms will help in evaluating which system is best at eliminating aberrations. The following technology is required to provide what is considered optimal within the current state of knowledge in this field: (1) scanning spot laser delivery, (2) robust eye tracking,(3) an accurate wavefront device, and (4) the wavefront-laser interface.

Cornea↗
PubMedDate not supplied

Molecular cell biology for the refractive corneal surgeon: programmed cell death and wound healing.

BACKGROUND: Variability of outcome following refractive surgical procedures is affected by corneal wound healing. Interactions between the corneal epithelium and stromal keratocytes affect both stromal remodeling and healing of the epithelium. These processes contribute to regression of initial effect, surface irregularity, and stromal scarring that occur following excimer laser photorefractive keratectomy (PRK). I review recent discoveries related to stromal-epithelial molecular interactions that provide insights into the cellular responses to refractive surgical procedures. RESULTS: Injury to the corneal epithelium stimulates programmed cell death (apoptosis) of the underlying anterior stromal keratocytes. I hypothesize that apoptosis of the keratocytes occurring immediately after epithelial injury associated with refractive surgical procedures initiates the subsequent wound healing response. Activated keratocytes subsequently repopulate the anterior corneal stroma where they produce collagen and other components associated with stromal remodeling. In addition, secretion of hepatocyte growth factor and keratinocyte growth factor by keratocytes increases after corneal epithelial wounding and these growth factors stimulate proliferation and inhibit differentiation of epithelial cells, effects which could promote epithelial hyperplasia associated with regression after photorefractive keratectomy. CONCLUSION: Corneal stromal-epithelial interactions help explain the different results that occur following excimer laser photorefractive keratectomy and laser in situ keratomileusis.

Animals↗