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At least 19 recordsLinked to original sources
PubMed1991

Utilizing research assistants and maintaining research integrity.

The appropriate use and supervision of research assistants is essential to the success of a research study and the avoidance of academic misconduct. The focus of this article is to provide guidelines for the new principal investigator regarding hiring, contracting, orienting, monitoring, and evaluating research assistants. Particular attention is given to techniques that will avoid academic misconduct resulting from research assistants being uninformed or unsupervised.

Biomedical Research↗
PubMed1990

Effects of alcohol on human aggression: an integrative research review.

This review used quantitative and qualitative techniques to integrate the alcohol and aggression literature. The primary purpose of the review was to determine if a causal relation exists between alcohol and aggression. The main meta-analysis included 30 experimental studies that used between-subjects designs, male confederates, and male subjects who were social drinkers. Studies using other designs or subject populations were integrated with meta-analytic procedures when possible and summarized descriptively when not. The results of the review indicate that alcohol does indeed cause aggression. However, alcohol effects were moderated by certain methodological parameters.

Aggression↗
PubMed2026

Convergent methodologies in prosthetic joint infection research: integrating transdisciplinary approaches to understand and prevent biofilm-driven failure of orthopaedic prostheses.

Prosthetic joint infections (PJIs) remain among the most devastating complications of arthroplasty, imposing substantial clinical, economic and patient burdens. Although culture-based diagnostics underpin current clinical practice, PJIs are biofilm-driven infections shaped by taxonomic diversity, spatial organization, host responses and surface interactions, meaning conventional approaches provide only a partial and often decontextualized view of the infection process. We examine how convergent methodologies can transform PJI research by integrating approaches that have traditionally been studied in isolation, including sequencing, transcriptomics, metabolomics, advanced imaging and culture-based characterization. We discuss how whole-genome sequencing, shotgun metagenomics, transcriptomic and metabolomic approaches resolve pathogen identity, functional activity and adaptive persistence and how cross-scale imaging and spatial biology techniques reveal where microbes colonize, interact and survive across implant surfaces. We highlight emerging opportunities to unify these datasets into coherent frameworks that capture both the molecular and physical dimensions of PJIs. Integrating these complementary approaches will enable a multi-layered understanding of PJIs that link composition, function and spatial organization. Ultimately, this provides a foundation for predictive diagnostics, precision antimicrobial strategies and improved implant design and supports a shift towards more effective, mechanism-informed management of implant-associated infection.

Prosthesis-Related Infections↗
PubMed1991

Integrating research activities, practice changes, and monitoring and evaluation: a model for academic health centers.

A study undertaken by the Joint Commission in 1986 proposed that some research activities at academic health centers (AHCs) be used to fulfill monitoring and evaluation requirements. This paper presents a framework for such use of research activities. To fulfill the monitoring and evaluation standards, AHCs and their medical staff departments must conduct planned and systematic quality assurance activities, and research and subsequent practice changes must be documented. In addition, particular research activities should correspond to the ten steps of the Joint Commission model of the monitoring and evaluation process. It is critical that research result in specific actions to improve care, along with follow-up monitoring and, when necessary, follow-up action.

Academic Medical Centers↗
PubMedDate not supplied

Shifting the paradigm: toward integrative research on mothers and children.

The mother-child relationship has been examined extensively but most research has centered on maternal characteristics associated with poor childhood developmental outcomes or maternal response to stressors. The "maternal deficit" model has misdirected research and intervention. Research on maternal depression based on the maternal deficit model has resulted in research designs that do not adequately address maternal outcomes. Research must be conceptualized to address parent-child relationships and situational factors that influence them.

Humans↗
PubMed1991

Integrating research and practice.

The opinion that research is not a legitimate activity for nurses has support in and outside the profession. It has been argued that nursing is a simple art that is not enhanced by science, and that research hinders rather than facilitates the provision of quality nursing services. This paper will examine these arguments and relate them to current controversies in nursing theory, education, research and practice.

Clinical Nursing Research↗
PubMed1992

Female workplace homicides: an integrative research review.

1. Between 1980 and 1985, murder on the job was the leading cause of fatal injuries for women compared to being the third leading cause for men. The annual female homicide rate per 100,000 women ranged from 0.05 to 0.7. 2. Risk factors that were identified included age 65 and over, black, and work involving the exchange of money. The primary cause of death was gunshot wounds. 3. Suggested prevention strategies were environmental controls, training, policy, and research. 4. Occupational health nurses need to recognize homicide as an occupational hazard, determine high risk employees and situations, and implement programs to reduce violence related stress.

Adolescent↗
PubMed1991

The effect of social contact on college students' attitudes toward severely handicapped students and their educational integration.

Research on integration suggests that the major benefit of educational integrated programmes is the facilitation of intergroup contact between mentally handicapped and non-handicapped students. The present study was designed to investigate the effect of different amounts of social contact with severely handicapped students on attitudes and emotional reactions of college students towards such students and their integration into mainstream education. The study was carried out in a tertiary college which has a link programme with a local school for pupils with severe learning difficulties. The results indicated that those participants who had social contact with severely handicapped students held more favourable attitudes and emotional reactions toward such students than did those who had no social contact with this group. The study concludes that the educational integration programmes can positively modify attitudes and emotional reactions of college students towards severely handicapped students. However, in order to implement an effective link or integration programme and to foster attitudes more favourable towards severely handicapped students, the study recommends that more opportunities for intergroup contact and social interaction between non-handicapped and handicapped students need to be provided.

Adaptation, Psychological↗
PubMed1990

The perceptual interaction of graphical attributes: configurality, stimulus homogeneity, and object integration.

Researchers have proposed that graphical efficacy may be determined, in part, by the nature of the perceptual interactions that exist between attributes used to create graphical displays. One extreme type of interaction is integrality, in which two or more physical dimensions are represented as a single psychological dimension in the observer. An alternative type of interaction is configurality, in which a global emergent dimension is available to the observer in addition to the component attributes. Thirteen stimulus sets, each composed of attributes commonly used in the design of graphs, were submitted to the performance-based diagnostics of integrality and configurality. Analyses suggest a continuum of configurality among the present stimulus sets, with little evidence for integral graphical attributes. The configural pattern of results was more common when two identical dimensions were paired (homogeneous stimuli) than when two different dimensions were paired (heterogeneous stimuli). However, there was no evidence that pairs of dimensions belonging to a single object (object integration) were any more configural than dimensions belonging to different objects. Object integration was, however, consistently related to inefficient performance in tasks requiring the filtering of one of two component dimensions.

Adult↗
PubMed1976

Research data integrity: a result of an integrated information system.

The toxicologic problems of today frequently require long-term, multidisciplinary experimentation involving large numbers of animals. In order to provide the extensive safety evaluation necessary to produce data that can be reasonably extrapolated to humans, automated research support systems have transcended the position of useful tools and have become an integral part of the total design of experimental protocols. For an automated information system to fully represent the reality of the experiment, it must be able to assure integrity, as well as provide for the storage, calculation, and retrieval of data values of the quality and quantity necessary for fulfilling protocol requirements. Guarantees against error and loss of data, in addition to flexibility and easy access, must be an inherent part of the system if the acceptance and condifence of the investigator are to be obtained. This paper discusses the criteria, philosophies, and benefits of integrated data systems that ensure integrity of toxicologic research support.

Computers↗
PubMed2025

Sustainability in translational genomics research with undiagnosed patients: What is it, why do we need it, and how do we do it?

PURPOSE: Genomics research enrolling undiagnosed patients can provide answers for one-third of participants, and more can be diagnosed through future reanalysis. The long-term value for participants has raised questions of the sustainability of these studies, but the meaning, goals, and best practices for sustainability remain unclear. METHODS: We conducted semistructured interviews with researchers leading studies enrolling undiagnosed patients in the United States and Canada and used thematic content analysis to summarize key themes. RESULTS: Researchers lacked consensus regarding what sustainability was actually intended to sustain, variably referencing study procedures, personnel, data access, and participant recontact. However, the primary driver of sustainability was widely shared as the perceived obligation to continue to search for answers for undiagnosed participants. Proposed sustainability strategies included diversifying funding sources, developing centralized data infrastructure, and building collaborations across disciplines and institutions. Researchers also emphasized the need to address ethical concerns, to integrate research with clinical care, and for leadership from research funders to guide these efforts. CONCLUSION: Although genomics researchers perceived continued obligations to undiagnosed participants, they also lacked a shared understanding of the goals of sustainability and called for coordinated efforts to develop centralized infrastructure that integrated research and clinical care.

Humans↗
PubMed1992

Interventions for children of divorce: toward greater integration of research and action.

A number of child-, family-, and system-focused interventions have been designed to prevent or reduce the negative effects of divorce on children. This article critically evaluates these intervention efforts by examining (a) their relation to basic research on the processes proposed to mediate children's postdivorce adjustment and (b) evaluation studies assessing the effectiveness of various programs. Although interventions address some of the factors proposed to mediate children's adaptation to divorce, the interplay between interventions and basic research on children's postdivorce adaptation is limited. Moreover, some intervention efforts appear to be beneficial, but most lack empirical documentation of their efficacy. This analysis leads to several recommendations for basic and applied research and for improving the response of the mental health field to the problems experienced by many children from divorcing families.

Adaptation, Psychological↗