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At least 19 recordsLinked to original sources
PubMed1977

[Biochemistry of collagen and the locomoter apparatus (Hereditary connective tissue diseases and rheumatic diseases. Part I].

The elementary collagen molecule consists of three chains rolled into a spiral and ending in nonhelical telopeptides. In cutaneous collagen, there are two types of chains, in cartilaginous collagen there is only one. In the synthesis, several enzymes play successive parts: proline hydroxylase, lysine hydroxylase, then pro-collagen peptidase and finally, lysine oxidase and hydroxylysine oxidase; their coordinated actions ultimately allow the chains to establish the transverse intra and intermolecular links which give the collagen fiber its cohesion. The type and number of these transverse links vary from one tissue to another. Specific collagenases make collagen degradation possible.

Animals↗
PubMedDate not supplied

[Problem of specific syndrome formation in psychosomatic disease situations. (Psychodynamics of rheumatic diseases)].

Three features of psychosomatic diseases with negative rheumafactor were psychoanalytically investigated (35 patients). Each of these diseases (the Palindromic Rheumatism, the Reiters Disease and the Psoriatic Arthritis), showed a characteristic syndrome. Corresponding with the patients with rheumafactor-positive Rheumatoid Arthritis was only the fact of inhibited aggressive impulses in the somatic field by the blockade of the muscle system. We believe that this study proves our earlier found thesis, that in psychosomatic diseases we have to work out the specific conflict, the specific psychodynamic ambivalence.

Adolescent↗
PubMed1977

[Complex therapy of rheumatic diseases].

Chronic progressing rheumatic diseases are not accessible to a satisfactory rehabilitation by a sole medicamentous treatment. In specialized departments of hospitals already very good results are achieved by the additional, coordinated use of operative and conservative orthopaedic measures, the physiotherapy and working therapy as well as by a psychological and social care apart from the treatment of lesions of the organs and sequels. The principle of the complex therapy in the hospital is gradually to be transferred to the outpatient care, achieving a full success of rehabilitation using rational methods of work.

Ambulatory Care↗
PubMedDate not supplied

[Problems in the handling of equipment for patients with rheumatic diseases].

Persons with rheumatic diseases in the hand-arm-system are hindered to use requisits in their daily activities, because they can only fulfill grasping and holding functions with great difficulties and pain. A substancial point in this analysis takes the questions of existing knowledge and experiences in ergonomics and medical therapy concerning design criteria for service equipment in the sense of joint protection and prevention. A confrontation and examples show that important design criteria for service equipment are contradicting themselves and that for planning and designing requisits of daily use and work it is necessary to develop directions for prophylactic joint protection.

Activities of Daily Living↗
PubMed1979

Influenza vaccination in patients with rheumatic diseases. Safety and efficacy.

The safety and efficacy of influenza vaccination were studied in 32 healthy volunteers and in 62 patients with systemic lupus erythematosus (SLE), rheumatoid arthritis, degenerative joint disease, and other rheumatic diseases. These individuals, none of whom was acutely ill, were examined at the time of immunization and one week, three weeks, and four months later. Flare-ups of rheumatic disease following immunization were infrequent and usually minor. Seroconversion to A/New Jersey/76 developed in 62% to 87% of all individuals and to A/Victoria/75 in 62% to 69%. Antibody responses to A/New Jersey/76 were significantly lower in young patients taking glucocorticoids compared to those not taking glucocorticoids. The antibody responses to A/New Jersey/76 and A/Victoria/75 in patients with SLE were not different from normal responses. Administration of these vaccines was safe in these patients with stable disease and induced antibody responses in most individuals.

Acute Disease↗
PubMed1978

Early radiologic signs of rheumatic disease.

The radiographic manifestations of rheumatic disease are varied. Proper interpretation of the observed roentgen abnormalities requires knowledge of the underlying pathogenesis and characteristic distribution of the disease. With this knowledge the physician may provide accurate and early diagnosis in many patients with arthritis.

Arthritis↗
PubMed1975

[Morphological points of departure for the therapy of rheumatic diseases].

Pathogenic mechanisms of several rheumatic diseases are reported. Besides signs of nonspecific inflammation there are characteristic features in some rheumatic disorders: in rheumatoid arthritis one can find mesenchymoid proliferation and - in seropositive cases only - necrosis ot tissue. In ankylosing spondylitis osseous metaplasia of the intervertebral discs, in psoriatic arthritis, osteoclastic and in osteoblastic changes without inflammation. In fibrositis syndrome, however, there was no evidence of inflammation, but one may detect local muscular lesions and proliferation of fibroblasts. Pain in osteoarthritis is always caused by secondary inflammation. Due to this data, the possibilities of treatment are discussed, especially those of nonsteroidal drugs.

Arthritis↗
PubMed1978

Antibody to extractable nuclear antigen in the rheumatic diseases.

Two hundred and eighty-four patients with various rheumatic diseases were studied for the prevalence of antibodies to extractable nuclear antigen (anti-ENA) using an improved haemagglutination technique. Anti-ENA rarely occurred in patients with rheumatoid arthritis, scleroderma, polymyositis, dermatomyositis and Sjögren's syndrome. Seventeen per cent (13/72) of patients fulfilling at least four preliminary ARA criteria for systemic lupus erythematosus (SLE) demonstrated anti-ENA. The predominant antibody was directed at ribo-nuclease-resistant ENA (anti-Sm). Antibodies to ribo-nuclease-sensitive ENA (anti-RNP) occurred in the minority of patients with SLE (2/72) and the mixed connective tissue disease syndrome (MCTD). A trend toward an increased incidence of renal disease in SLE patients with anti-Sm was present. Sequential analysis of anti-Sm in patients with SLE showed a fall in titre paralleling the normalization of anti-DNA antibody titres and serum complement values. No case of unrecognized MCTD was uncovered in our rheumatic disease population.

Adult↗