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At least 19 recordsLinked to original sources
PubMed2006

Java project on periodontal diseases. The natural development of periodontitis: risk factors, risk predictors and risk determinants.

OBJECTIVE: To identify risk factors, risk predictors and risk determinants for onset and progression of periodontitis. MATERIAL AND METHODS: For this longitudinal, prospective study all subjects in the age range 15-25 years living in a village of approximately 2000 inhabitants at a tea estate on Western Java, Indonesia, were selected. Baseline examination was carried out in 1987 and follow-up examinations in 1994 and 2002. In 2002, 128 subjects could be retrieved from the original group of 255. Baseline examination included evaluation of plaque, bleeding on probing, calculus, pocket depth, attachment loss and presence of Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, spirochetes and motile microorganisms. RESULTS: The mean attachment loss increased from 0.33 mm in 1987 to 0.72 mm in 1994 and 1.97 mm in 2002. Analysis identified the amount of subgingival calculus and subgingival presence of A. actinomycetemcomitans as risk factors, and age as a risk determinant, for the onset of disease. Regarding disease progression, the number of sites with a probing depth > or = 5 mm and the number of sites with recession were identified as risk predictors and male gender as a risk determinant. CONCLUSION: Screening of these parameters early in life could be helpful in the prevention of onset and progression of periodontal diseases.

Adolescent↗
PubMed2002

Epidemiologic analyses of risk factors, risk indicators, risk markers, and causal factors. The example of albuminuria and the risk of cardiovascular disease in diabetes.

Much of the practice of modern medicine deals with prevention of the consequences of chronic conditions, including diabetes, hypertension, obesity, asthma, chronic bronchitis, and inflammatory bowel diseases. To achieve this end, identifying people at risk for these consequences and then initiating the appropriate, evidence-based preventive therapies are key. Characterization and study of risk factors are at the core of this effort and represent the only way that high-risk individuals can be identified. These risk factors can be any imagined variable, ranging from a genetic mutation to a blood result, a previous disease, exposure to an infectious agent or toxin, a socioeconomic state, ethnicity, birth weight, or country of origin. All causal factors for an outcome are risk factors for that outcome; reducing these risk factors almost certainly reduces the outcome. The converse is usually not true, however: identification of a risk factor reveals little about its causal connection to the outcome in question, and reducing this risk factor may or may not reduce the outcome. Once high-risk individuals are identified on the basis of their risk factor profile, the relevant clinical question relates to which therapies have been identified clearly that will reduce the risk or the outcome. If modification of the level of the risk factor is considered therapeutically, the question of whether the risk factor is also a good surrogate outcome must be answered. Information regarding whether the risk factor causes the disease is highly desirable; however, it is often unavailable and is not required before making therapeutic decisions.

Albuminuria↗
PubMed1998

Endothelial dysfunction in cardiovascular disease: risk factor, risk marker, or surrogate end point?

Endothelial dysfunction is a feature of the early stages of atherosclerotic cardiovascular disease. It also is almost invariably associated with recognized cardiovascular risk factors, including those that are irreversible (such as age and family history) and those that are reversible (such as hypertension and hypercholesterolemia). It remains the subject of debate whether endothelial dysfunction can be considered an independent risk factor or, perhaps more plausibly, an intermediate or surrogate end point. However, although the relevance to research into cardiovascular pathophysiology is not in dispute, there remains uncertainty about its relevance as a therapeutic target. Overall, the available evidence suggests that targeting of the conventional major risk factors remains the primary strategy, but an ancillary effect on intermediate end points, such as an improvement or reversal of endothelial dysfunction, constitutes an additional potential benefit.

Biomarkers↗
PubMed2004

Atherosclerosis of the aorta: risk factor, risk marker, or innocent bystander? A prospective population-based transesophageal echocardiography study.

OBJECTIVES: The goal of this study was to investigate whether complex aortic atherosclerosis is associated with increased risk of vascular events in a non-selected population. BACKGROUND: In selected high-risk patients, aortic atherosclerosis is associated with increased risk of vascular events. METHODS: We describe the relationship between simple versus complex (>4-mm thick or mobile debris) aortic atherosclerotic plaques and vascular events during follow-up in a random sample of 585 persons (age > or =45 years) using 1993 to 2000 data from the Stroke Prevention: Assessment of Risk in a Community (SPARC), a prospective population-based longitudinal study. RESULTS: At five-year median follow-up (range, 0.5 to 6.5 years), cardiac events (death, non-fatal myocardial infarction, coronary revascularization, heart failure associated with coronary artery disease) and cerebrovascular events (ischemic fatal and non-fatal strokes, transient ischemic attacks) had occurred in 95 subjects and 41 subjects, respectively. Age, male gender, prior coronary artery disease, higher pulse pressure, and diabetes were significant cardiovascular predictors. Age, prior myocardial infarction, and a history of atrial fibrillation were significant cerebrovascular predictors. Simple aortic plaques (253 persons) were not independently associated with either cardiac or cerebrovascular events. Complex plaques (44 persons) were marginally associated with cardiac events, adjusting for age and gender (hazard ratio [HR], 2.28; 95% confidence interval [CI], 1.11 to 4.68; p = 0.053 for two degrees of freedom [complex and simple plaques vs. no plaques]) but not after adjusting for additional clinical risk factors (HR, 1.22; 95% CI, 0.57 to 2.62; p = 0.64). Complex plaques were associated with cerebrovascular events only univariately. CONCLUSIONS: Aortic atherosclerotic plaques are not associated with future cardiac or cerebrovascular events. Aortic atherosclerosis may not be an independent risk factor for vascular events in the general population.

Aged↗
PubMed2006

Anthracyclines, mitoxantrone, radiotherapy, and granulocyte colony-stimulating factor: risk factors for leukemia and myelodysplastic syndrome after breast cancer.

PURPOSE: To determine the risk factors for acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) after breast cancer. PATIENTS AND METHODS: We conducted a case-control study among women treated for breast cancer between 1985 and 2001 in French general hospitals, cancer centers, or clinics. We included 182 AML and MDS patients and 534 matched controls. Breast cancer characteristics, type of treatment, and family history of cancer were compared in both groups. RESULTS: The risk of AML/MDS was increased after topoisomerase-II inhibitor-based chemotherapy (P < 10-16) and was higher for mitoxantrone-based chemotherapy than for anthracycline-based chemotherapy (relative risk [RR] = 15.6; 95% CI, 7.1 to 34.2; and RR = 2.7; 95% CI, 1.7 to 4.5, respectively). After adjustment for other treatment components, the risk of AML/MDS in patients who received radiotherapy was multiplied by 3.9 (95% CI, 1.4 to 10.8) but was not increased by alkylating agents. Patients receiving granulocyte colony-stimulating factor (G-CSF) support had an increased risk of AML/MDS (RR = 6.3; 95% CI, 1.9 to 21), even when controlling for chemotherapy doses. Similar results were obtained when AML and MDS were considered separately. CONCLUSION: This large case-control study demonstrates that the risk of AML/MDS is much higher with mitoxantrone-based chemotherapy than with anthracyclines-based chemotherapy in a population of women recently treated for breast cancer. The risk of AML/MDS associated with mitoxantrone must be kept in mind when using this drug to treat diseases other than breast cancer (eg, prostate cancer or multiple sclerosis). In addition, our study suggests the need to monitor the long-term effects of G-CSF therapy.

Acute Disease↗
PubMed1998

[Heart rate: risk factor, risk marker].

When a correlation between an individual characteristic and the incidence of a disease is detected in epidemiology, this characteristic must satisfy four criteria before it can be considered to be a risk factor it must be strongly associated, universally associated regardless of the population, gender, race, associated independently of already recognized factors, especially age, and a cause-and-effect relationship must be demonstrated by a study influencing this characteristic. The first three criteria define the risk marker. Various examples are given, including that of heart rate and overall and cardiovascular morbidity and mortality.

Cardiovascular Diseases↗
PubMed1991

Are the Brown and Harris "vulnerability factors" risk factors for depression?

The Brown and Harris model of depression holds that certain "vulnerability factors"--namely early maternal loss, lack of a confiding relationship, greater than three children under the age of 14 at home and unemployment--can interact with "provoking agents" to increase the risk of depression. The validity of this model has been widely debated, with most of the discussion concerning the interactive nature of the model. There has been relatively little attention paid to the possibility that the "vulnerability factors" may be risk factors for depression. The purpose of this paper is to determine whether the four Brown and Harris "vulnerability factors" are associated with an elevated risk of depression, irrespective of whether they may interact with provoking agents. The analysis contained in this paper utilizes power analyses and confidence intervals. The findings suggest that the lack of a confiding relationship is strongly associated with depression, and that all four of the "vulnerability factors" may be associated with an increased risk of depression.

Depressive Disorder↗
PubMed2002

Are psychosocial factors, risk factors for symptoms and signs of the shoulder, elbow, or hand/wrist?: A review of the epidemiological literature.

BACKGROUND: In 1993, an extensive review on the role of psychosocial factors in the development of musculoskeletal problems was published by Bongers et al (1993). Since then, additional reviews on this topic have been published; however, none of these focussed on upper limb problems. METHODS: In this systematic review, the methodological quality of all studies was assessed and levels of evidence were apriori defined. RESULTS: The large majority of the studies reported an association between at least one work-related psychosocial factor and adverse upper extremity symptoms or signs. High-perceived job stress was consistently associated with all upper extremity problems (UEP) in high and lower quality studies. Although not often studied, non-work-related stress was also consistently associated with UEP. In addition, there was some evidence for a relationship between high job demands and UEP, although the results did not meet the pre-set criterion for consistency. CONCLUSIONS: High job stress and non-work-related stress reactions are consistently associated with UEP. In addition, high job demands is also in most studies associated with these disorders. Firm conclusions on the role of these factors in the etiology of UEP are not possible due to the cross-sectional nature of most studies.

Arm Injuries↗
PubMed2005

HIV/AIDS epidemic in India: risk factors, risk behaviour & strategies for prevention & control.

Since the first report of HIV infection in India in 1986, the virus has spread all over the country although there is geographic variation. There are estimated 5.1 million people infected with HIV with an overall estimated adult prevalence below 1 per cent. Surveys carried out in different sub-populations have yielded prevalence estimates, but data on HIV incidence are limited. Both HIV serotypes 1 and 2 exist in India and HIV-1 C is the commonest subtype reported. Sexual transmission of HIV is most predominant. Spread of HIV in intravenous drug use settings is localized mostly in the north eastern region and metropolitan cities and parent to child transmission is on the rise. Dual epidemics of HIV and tuberculosis, increase in the number of infected women, stigma and discrimination are the main concerns in the Indian HIV/AIDS scenario. There is an increasing political will and commitment for HIV prevention and control efforts in India. A multi-disciplinary approach combining targeted interventions like early identification and treatment of STDs, condom promotion, blood safety, drug de-addiction programs and expanding and strengthening VCTCs and long-term strategies like awareness oriented to behavioural change especially among vulnerable populations, young people and women, steps towards improvement of literacy, status of women and overall development, reduction in poverty and development of primary prevention interventions like vaccines and microbicides will have to be considered for effective prevention and control of AIDS in India.

Female↗
PubMed2000

Quantitative analysis of cumulative trauma risk factors and risk factor interactions.

This study identifies the strongest occupational risk factors and risk factor interactions in the development of indicators associated with cumulative trauma disorders (CTD). Suggestions for minimizing the occurrence of indicators associated with onset of CTD are presented. Five Occupational risk factors and six risk factor interactions were evaluated to determine their contribution to accepted indicators of the onset of CTD, including exertion, discomfort, difficulty, and fatigue. Taguchi's level-analysis procedure was used to design a 16-trial hammering experiment and to analyze the results. From the hypothesized occupational risk factors, repetition was found to have the strongest effect on the values of the physiological and subjective indicators of the onset of CTD.

Adult↗
PubMed2001

Influence of parental histories of cardiovascular risk factors on risk factor clusters in the offspring.

OBJECTIVES: To assess the effect of parental histories of cardiovascular risk factors on risk factor clusters (RFC) in representative samples from three French populations (MONICA centers of Lille, Strasbourg, Toulouse). MATERIAL AND METHODS: In a representative cross-sectional study, we screened 1,291 males and 1,264 females, aged 35-64 years. Subjects were defined as RFC cases when they were affected by at least 2 disorders among, hypertension (systolic or diastolic blood pressure >=140/90 mmHg and/or antihypertensive drug), diabetes (physician-diagnosed diabetes and/or glycemia >=7.0 mmol/l and/or hypoglycemic drug), and dyslipidemia (triglycerides > 2.26 mmol/l and/or HDL-cholesterol<0.9 mmol/l in men and<1.2 mmol/l in women). Nineteen percent of the subjects were RFC cases. Parental histories of cardiovascular risk factors (hypertension, diabetes, hyperlipidemia) were positive if they were under 65. About 29% of the subjects had at least one parental history of risk factor. RESULTS: After adjustment for sex, age, educational level, sedentary lifestyle, alcohol consumption, body mass index, LDL cholesterol and center, parental histories of cardiovascular risk factors were significantly associated with the RFC. One, two, or at least three parental histories were significantly associated with increased odds of being RFC cases (adjusted OR 1.39 95% CI [1.05-1.82], 2.90 95% CI [1.91-4.40], 2.93 95% CI [1.41-6.08]). Furthermore, a maternal-only history vs a paternal-only history of hypertension or diabetes was associated with strong odds of being an RFC case. CONCLUSION: At least a single cardiovascular risk factor in parents was significantly associated with RFC in offspring, independently of environmental parameters.

Adult↗