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Fluorochrome labelling in Roman period skeletons from Dakhleh Oasis, Egypt.

A histological aging study of femoral midshafts in a late Roman period sample from the Dakhleh Oasis, Egypt, showed discrete fluorochrome labelling. The fluorochrome is yellow-green in colour and fluoresces at a wavelength of 525 nm. The labelling occurs at the mineralization fronts and is so distinct that several histomorphometric measurements were made. The percent labelled surface values ranged from 6.03% to 59.34%, and the mean distance between labels ranged from 13.57 to 20.63 microns. Teeth from several individuals were also labelled within the enamel matrix. Comparisons were made between the patterns of fluorescent labelling from this population and from patients treated with interval and continuous dosages of tetracycline. The results collectively indicate that the fluorochrome is most likely tetracycline that made its way into the bone (in vivo) via stored grain contaminated by Streptomycetes. The labelling was differential, much like that of the patient on interval doses of tetracycline, so it is argued that the tetracycline was ingested occasionally, probably on a seasonal basis. The lack of bone infection in the adults (n = 29) suggests that the tetracycline may have provided some antibiotic protection in this population.

Bone and Bones↗

Humerus varus deformity in Roman period burials from Kellis 2, Dakhleh, Egypt.

Humerus varus deformity (HVD) occurs unilaterally in a female (#85) skeleton and bilaterally in a male (#124) from Kellis 2, a Roman period cemetery (circa 300-450 AD) from Dakhleh, Egypt. The affected humeri were shortened, their glenohumeral joints deformed, and their upper diaphyses were angulated. The skeletons were otherwise normal. The severity of the changes suggests that the underlying growth disturbances occurred early in postnatal development. The differential diagnosis considers the mucopolysaccharidoses, thalassemia, infection, and birth trauma, with the latter being favored. Clinical data show limited morbidity or functional impairment in individuals with HVD, although radiographic analysis suggests that #85 may have favored her dominant arm. Ortner and Putschar (1981), and Hershkovitz et al (1991) describe the only other archaeological cases of HVD. These authors provide useful, though limited, information on the differential diagnosis of HVD in archaeological specimens. Future research should focus on documenting the prevalence and expressivity of HVD in Mediterranean population samples where thalassemia evolved. HVD is relatively common in thalassemics and this approach would be valuable for documenting the range of osseous responses characteristic of HVD.

Animals↗

Evolution in the conceptualization of dementia and Alzheimer's disease: Greco-Roman period to the 1960s.

Most histories of senile dementia commence with Alois Alzheimer's description in 1906 of the first case of Alzheimer's disease, yet the history of senile dementia before 1906 is quite rich, dating back to the ancient Greek and Roman philosophers and physicians. Over the 2500 years since ancient times, the concept of senile dementia has evolved from a rather vague notion that mental decline occurred inevitably in old age, to become defined today by a distinct set of clinical and pathological features with the potential for treatment and prevention within grasp. Throughout history, many elderly individuals with unpredictable behavior were sequestered in institutions, and the line between mental disorders and senile dementia was hazy at best. The identification of Alzheimer's disease at the onset of the 20th century was a turning point for the understanding of senile dementia, and the concepts and histological findings presented by the early researchers of Alzheimer's disease remain relevant still today. Indeed, these early findings are proving to be a continuing source of insight, as many of the issues debated at the turn of the century remain unresolved still today. This paper thus traces the history of the evolution of our current conceptualization of Alzheimer's disease from the amorphous Greco-Roman concept of age-associated dementia.

Alzheimer Disease↗

Possible case of hyperparathyroidism in a Roman period skeleton from the Dakhleh Oasis, Egypt, diagnosed using bone histomorphometry.

A histomorphometric study of thin femoral head sections of a skeletal sample from the Dakhleh Oasis, Egypt, dated from circa 36 B.C. to 400 A.D., identified an adult female (Dk31-A1) in her mid-50s with a high percentage resorption surface with tunneling resorption as is typically found in hyperparathyroidism. Five static histomorphometric bone parameters were measured with the following results for this individual: 1) mean wall thickness, 41.94 micron, 2) trabecular bone volume, 18.54%, 3) surface volume, 4,070 mm2/cm3, 4) mean trabecular diameter, 132 microns, and 5) total resorption surface, 12.31%. The overall histomorphometric features and differential diagnosis support the diagnosis of hyperparathyroidism. We conclude that histomorphometry of dried bone, particularly in this case where preservation is ideal, is a valuable investigative technique for paleopathology.

Bone and Bones↗

Rationality versus irrationality in Egyptian medicine in the pharaonic and Graeco-Roman periods.

During the Ptolemaic Period (332 BC-31 BC), many Greek medical practitioners settled in Egypt where they established an outstanding medical school and developed a distinctive rational approach to diagnosis and treatment which some scholars have regarded as a significant advance on earlier Egyptian procedures. However, Egyptian medicine itself combined both 'rational' and 'irrational' procedures, and extant ancient sources indicate that 'rationality' was not a new concept. Also, several other medical advances that modern writers have usually attributed to the Greeks can be identified in earlier Egyptian traditions. Nevertheless, the limitations of extant textual and archaeological evidence constrain the scope of studies in this area, and new information is required to carry the debate forward.

Egypt, Ancient↗

Thermoluminescence dating of archaeological artefacts from the Middle Neolithic, Bronze Age and the Roman Empire period.

Thermoluminescence (TL) dating was applied for artefacts found near the small village of Michelstetten, Lower Austria. Settlements in this region can be traced hack a long time and, according to archaeologists, the discovered artefacts may be as old as 6000 years. A modified sample preparation technique based on the fine-grain method was developed. This technique results in a higher reproducibility and reduces the overall preparation time. For some artefacts the new information of the TL dating leads to an unforeseen re-interpretation of the archaeological age. Furthermore, an iron furnace from the period of the Roman Empire could be dated. For the first time, it was possible to estimate correctly the point of time of the burn-down of an ancient wooden house via an analysis of the house's clay plaster. The fire took place in the sixth century; this was confirmed by dating ceramic artefacts.

Archaeology↗

Patterns of dental enamel defects at ancient Mendes, Egypt.

The dental remains of 88 individuals from Old Kingdom, First Intermediate, and Greco-Roman periods at the ancient Egyptian site of Mendes (Tell er-Rub(c)a) were examined for dental enamel hypoplasia, and the results reported here provide some of the first comparative data on enamel defects in ancient Egypt. Overall, 48% of the individuals in the sample have one or more teeth with hypoplasia, with 17% of permanent teeth and 8% of deciduous teeth affected. The permanent teeth account for 87% of the total number of affected teeth, a prevalence over deciduous teeth that is significant at alpha = 0.05. Permanent and deciduous teeth display different patterns of hypoplasia, with the former exhibiting both discrete pitting and linear furrowing, and the latter exhibiting only pits. Teeth with linear defects significantly outnumber those with pits by a factor of more than three to one. Only permanent canines display more than one lesion on a tooth, with a mean of 1.4 defects per affected tooth. Although calculation of the age of insult from lesion position is imprecise, it appears that stress episodes occurred most commonly between approximately 3-5 years of age. The presence of pits in the deciduous dentition, however, suggests that physiological stresses began in utero. There is no statistically significant difference in the frequency of enamel defects between males and females. An observed decrease in the frequency of defects from the Old Kingdom period to the subsequent First Intermediate and Greco-Roman periods is not significant at alpha = 0.05, although such a decrease is expected given epigraphic and other data that refer to prolonged drought and malnutrition in the late Old Kingdom. The calculated chi(2) value of 3.83 is significant at the 0.10 level, however, and since our sample is rather small and the magnitude of the chi-square statistic is a function of sample size, we recommend that future research investigate further the relationship between the frequency of enamel defects and the time period in which they occur.

Dental Enamel↗

Geomorphological evolution and environmental reclamation of Fusaro Lagoon (Campania Province, southern Italy).

Analysis of morphological, geological and environmental characteristics of the Fusaro Lagoon has shown the present degraded condition of the lagoon and the perilagoon area. The lagoon developed during the mid-Holocene within a wide marine bay confined between the coastal volcanic structures of Mt. Cuma to the north and Torregaveta to the south in the western part of the Phlegrean Fields. Subsequently, the bay was gradually filled with pyroclastic materials from phlegrean eruptive vents and sediments carried by the rivers Volturno and Clanis, thus, creating an open lagoon. It then evolved into a partially closed lagoon due to the formation of a continuous littoral spit during the late Holocene, probably wider than the present-day one and surrounded by marshlands. Finally, the total closure of the lagoon took place in the Graeco-Roman period, following the stabilization of the dune ridge, and it assumed a shape similar to present-day one only towards the end of the 18th century. Between the Roman period and 1941, three lagoon channels were opened in order to avoid the frequent environmental crises which continue to affect, although for different reasons, this salt-water basin. The basin has been exploited for more than 2000 years not only for mollusc culture and pisciculture, but also for the maceration of hemp and flax. In the 1980s, in order to reduce the effects of the environmental crises, dredging of the lagoon bottom has been carried out, altering the hydrogeological equilibrium and that of the ecosystem. Over the past 30 years, the supply of raw sewage of domestic, agricultural and industrial origin has ensured the presence of a high concentration of pollutants, including heavy metals. On the basis of the data obtained and in order to restore this sensitive transitional environment, eco-compatible interventions are proposed which aim at morphological and hydrologic resettlement, abatement of pollutants on the bottom of the basin, reintroduction of endemic molluscs, together with monitoring the quality of sediments and both sea-lagoon waters and groundwater.

Agriculture↗

Diet reconstruction in the Roman era.

The samples from the proximal femora were taken from 12 cementeries from the Roman period. The skeletons date from the 1st-4th centuries A.D. Trace element analysis was used in order to reconstruct the basic diet. The sites that best corresponded to the model of Old Germanic diet described by ancient authors "meat, milk and cheese" were found in the Pruszcz Gdanski East Pomerania region close to the Baltic sea as well as in region Halle (Niemberg) and not far from Donau (Sládkovicovo). This diet is characterized by a large amount of protein and consequently of zinc. In the original Old Germanic region in a time period of more than 1000 years (from 400 B.C. to 700 A.D.) there is the same type of trace elements sources for bones and also the same type of the diet. This possibly distinguishes Germanic soldiers (aboriginal) from others groups in Roman legionary camps. It seems that the Donau River is very important for predicting the type of diet in the Roman period. North of the river animal component prevails south of the river vegetal component prevails. The rich agricultural land along the Donau River and in the Pannonian plains affects social arrangement as well as the structure of bones in Germans and Sarmats in the 2nd-4th centuries. Lead became a civilization element. It appeared in the diet of the Greek and Romans. Contamination varied with different social classes. We have found higher lead concentration in the femurs of the Germans than in those of the Sarmatians. The highest concentration we found was in Pannonian towns (Gorsium, Sopianae) and legionary camps (Straubing, Gerulata). In reference to age, the maxima of the highest lead concentrations in Gerulata II are between 11 and 13 years of age and between 40 and 50 years.

Archaeology↗

[Medicines and thermal treatment in Pautalia, Thrace].

The city of Pautalia (Kyustendil in Bulgaria) is located near thermal springs in the Strymon valley (Strouma), on a site occupied from the Iron Age onward by the Thracian tribe of Dentheletes. The temple of Asclepios and the walls of Pautalia, located on the hill of Hissarlaka, as well as the roman thermae in the center of modern Kyustendil are among the more important archaeological vestiges in the area. In 1990, near the village of Dragodan, district of Kyustendil, different surgical instruments in bronze were unearthed in a tumulus attributed to the roman period (IInd century A.D.). During the excavation of another tumulus in 1992, a truly exceptional discovery was made near the town of Kotcherinovo, district of Kyustendil: A variety of medicines were discovered in a small bronze case, dating from the roman period (IInd century A.D.). The complete results of the analysis of these substances and few hypotheses about their possible use are presented in this publication.

Balneology↗

Continuity or colonization in Anglo-Saxon England? Isotope evidence for mobility, subsistence practice, and status at West Heslerton.

The adventus Saxonum is a crucial event in English protohistory. Scholars from a range of disciplines dispute the scale and demographic profile of the purported colonizing population. The 5th-7th century burial ground at West Heslerton, North Yorkshire, is one of the few Anglian cemeteries where an associated settlement site has been identified and subjected to extensive multidisciplinary postexcavation study. Skeletal and grave good evidence has been used to indicate the presence of Scandinavian settlers. A small, preliminary study using lead and strontium isotope analysis of tooth enamel, mineralized in early childhood, from Neolithic/Early Bronze Age (n = 8), Iron Age (n = 2), and Early Anglo-Saxon (n = 32) skeletons, was carried out to directly investigate this hypothesis. Results suggest that lead provides dissimilar types of information in different time periods. In post-Roman England, it appears to reflect the level of exposure to circulated anthropogenic rather than natural geological lead, thus being a cultural rather than geographical marker. Consequently, only strontium provides mobility evidence among the Anglian population, whereas both isotope systems do so in pre-Roman periods. Strontium data imply the presence of two groups: one of "local" and one of "nonlocal" origin, but more work is required to define the limits of local variation and identify immigrants with confidence. Correlations with traditional archaeological evidence are inconclusive. While the majority of juveniles and prehistoric individuals fall within the "local" group, both groups contain juveniles, and adults of both sexes. There is thus no clear support for the exclusively male, military-elite invasion model at this site.

Dental Enamel↗