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Study of arboviruses in Romania (1958--1978). Results obtained in the "Stefan S. Nicolau" Institute of Virology.

The results obtained in the Institute of Virology by the study of arboviruses in Romania are reviewed. Isolation of tick-borne encephalitis virus and detection of specific serum antibodies in humans, animals and migratory birds demonstrate its presence on the territory of Romania. Serum antibodies could also be detected to other three flaviviruses (West Nile, Ntaya, dengue types 1, 2, 3), though none of them could be isolated in our country. However, isolation of Kemerovo and Tahyna viruses and detection of antibodies to these viruses as well as to Calovo virus draw attention to the possibility of human infections with arboviruses belonging to Kemerovo, California and Bunyavirus groups.

Animals

Smoking habits in Romania.

The main aspects and consequences of tobacco use resulting from a series of field surveys in Romania are reviewed. The proportion of smokers in middle-aged adults is about 10 per cent for women and 40 to 50 per cent for men. Cigarettes are practically the only form of tobacco consumed--cigars are very rarely smoked and pipe-smoking accounts for less than 1 per cent of tobacco use. Less than 10 per cent of smokers use more than 25 cigarettes a day. Age at starting to smoke is low, with a quarter of smokers taking up the habit by the age of 15. Ninety per cent of the smokers admit to inhaling, and about half the men and nearly all the women smoke filter cigarettes.

Adolescent

Recent progress in the study of occupational lung diseases in Romania.

This paper reviews studies of occupational lung diseases in Romania in the last two decades. Work concerned with the effects of exposure to textile fibres, irritant gases and fumes in the chemical industry, welding fumes, asbestos, cadmium oxide, and the relation between dust exposure, pneumoconiosis, and chronic bronchitis is briefly presented.

Asbestosis

Some aspects of the environmental exposure to arsenic in Romania.

The main sources of arsenic emission in Romania are ore smelters and refineries. Arsenic determinations were carried out by the silver diethyldithiocarbamate spectrophotometric method on hair and urine samples taken from smelter workers and individuals residing in two polluted areas and three areas not polluted by arsenic. Arsenic in hair was found to be a more reliable biologic test than tests on urine, obviously reflecting the differences in arsenic concentrations in workroom air. Repeated determinations for arsenic content after 3 years revealed a twofold increased rate in the 48 re-examined workers. Hair arsenic analysis in people living in two locations near an ore smelter and a refinery indicated high-levels compared to those of individuals residing in nonpolluted areas. Epidemiological studies are necessary in order to ascertain effects of heavy arsenic exposure in relation with concurrent exposures to respiratory irritants and metals.

Air Pollutants, Occupational

[History of smallpox vaccination in Romania and source of the IC strains of vaccinia virus].

Smallpox existed in Romania since the 17th century, when both variolation and vaccinia were used for preventing the disease. Jenner's vaccination was performed in 1801 in Cluj and Tirgu Mures and extended to the entire country during the following 31 years. The vaccinia virus strain used for preparing the smallpox vaccine was received in 1893 from the Vaccine Institute of Berlin by Prof. Riegler of the Faculty of Veterinary Medicine, Bucharest. In 1949, it was taken over by the Cantacuzino Institute and has been carried through at most 27 passages in buffalo calves ; it is now designated as strain ICn+m27.

History, 18th Century

[Tuberculosis in Romania (author's transl)].

The incidence of tuberculosis in Romania has decreased considerably over the past years, particularly since 1972 when the combined rifampicin-ethambutol-pyrazinamide therapy was introduced. During the period 1968-1977 it fell from 127.9 per 100,000 to 73.4 per 100,000. The incidence of relapses fell at a slower rate. The most endangered are the 20-24 years age-group and old people; but here again the number of cases tends to fall. Childhood tuberculosis showed a yearly decline by an average of 20%. Bacteriological examinations and diagnosis are assuming increased importance.

Adolescent

Investigations on the presence of antibodies to Tahyna virus in Romania.

Serological results are presented of the HAI reaction to Tahyna virus performed in 1,749 apparently healthy subjects from two countries of Romania where Culex pipiens mosquitoes occur frequently, in 113 febrile patients (some of which exhibited signs of interstitial pneumonia) and in 675 domestic animals (swine, cattle, sheep and goats).

Animals

Investigations on the presence of hemagglutination-inhibiting antibodies to dengue virus in apparently healthy subjects of several counties in Romania.

The presence of hemagglutination-inhibiting (HAI) antibodies to dengue virus, types 1, 2, and 3 was studied in 1219 apparently healthy subjects of four counties in Romania. The proportion of positive reactions was of 0.40% to type 1, of 1.23% to type 2, and of 3.90% to type 3. Antibody proportion was different from one county to another.

Antibodies, Viral

Epidemioligical particularities of influenza outbreaks in a town of Romania during 1975.

Results are presented of the complex epidemiological influenza surveillance in a large town of Romania during 1975. The comprehensive and unitary methodology including systematic laboratory, clinical and epidemiological investigations supplied data on the influenza type A outbreak recorded during the first term of 1975. The factors of importance for epidemiological prognosis -- seroepidemiological indicators of the immunological profile of the population according to age groups, serodiagnostic and virological investigation clinically diagnosed influenza cases, complex epidemiological surveys in representative foci, study of the antigenic structure of the influenza strains isolated -- are outlined. The importance of a continuous, complex influenza surveillance for the differential orientation of prophylaxis and control steps is emphasized.

Adolescent

Incidence of hepatitis B surface antigen (HBsAg) in some areas of Romania.

The incidence of HBsAg in several areas of Romania was studied by 253,460 routine determinations performed from 1973 to 1975. HBsAg incidence was of 1.5% in blood donors and reached the highest value in acute viral hepatitis patients undifferentiated according to the clinical form. The values obtained were in agreement with the results of other studies covering more limited zones of the country. Considerable differences in HBsAg incidence depending on geographic area were observed.

Adult

[Sensitivity to antibiotics and chemotherapeutic agents in some strains of Salmonella typhi isolated in Romania during the period 1974-1976].

Investigations were carried out on 781 S. typhi strains isolated from patients and carriers. Testing of the sensitivity to chemotherapeutical agents by diffusiometry and the incorporation technique led to the detection of four resistant strains: 1 strain isolated by coproculture from a carrier since 1958, resistant to A, K, N, Ca and Cf and 3 strains isolated by coproculture, biliculture and uroculture from a carrier since 1974, resistant to A and Ca. The R factors of these strains were transferred in their totality. The resistant strains did not manifest any particular pathogenicity for the laboratory animal, and their immunogenic potential was below that of the current typhoid vaccine. None of the 781S typhi were resistant to Cmx, C, G, T, Co and Po. Consequently, in Romania Chloramphenicol may be used in continuation in the treatment of typhoid fever, and Cotrimoxazol, Gentamycin, Tetracyclin and Ampicillin are and remain reserve substitutes. The possible unexpected appearance of resistant S. typhi strains demand, however, further control of the sensitivity to chemotherapeutics of all the isolated strains.

Anti-Bacterial Agents

Restricting legal abortion: Some maternal and child health effects in Romania.

The dramatic rise of the Romanian birth rate in 1967 following the restrictive abortion decree of late 1966 is well known. Less well known are significant changes in key maternal and child health indicators in the period after 1966. Possible reasons for these changes are discussed as are the implications of the Romanian experience for population policy and abortion research in the United States.

Abortion, Legal