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Results for “SARCOMA, GIANT CELL”

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At least 19 recordsLinked to original sources
PubMed1989

[Giant cell sarcoma: a rare breast tumor].

This is a case report on a giant cell sarcoma or malignant osteoclastoma of the mammarian gland. Clinical diagnosis of this very rare tumor was of an exulcerating breast carcinoma. Histologically, this tumor shows epulis-like giant cells. Pathogenetically, a metaplasia of stromal cells, and of the glandular epithelium, is discussed. A simple mastectomy with extirpation of the axillary lymph nodes was performed. No metastases were found.

Aged↗
PubMed1986

[Multiple primary tumors of the brain (rare case)].

The author describes clinical and morphological findings about a combination of 2 brain tumors--preventicular astrocytoma of the right hemisphere and giant cell tumor of the pons (giant cell sarcoma?, giant cell glioblastoma?) which gave a metastasis into the area of the interventricular foramen. The author notes the rarity of such a combination and the difficulty of clinical interpretation of the case which became clear only after autopsy. The difficulties of the histological verification of pons tumor and its possible histogenesis are discussed.

Astrocytoma↗
PubMed2006

Follicular dendritic cell sarcoma mimicking giant cell carcinoma of the pancreas.

Extranodal follicular dendritic cell (FDC) tumors are rare. Recognition of the morphological spectrum of FDC tumors is important to clinical diagnosis. Herein is presented a case of pancreatic FDC sarcoma with unusual clinicopathological features. A 64-year-old male patient presented with weight loss, poor appetite, abdominal fullness, mild anemia and mild peripheral eosinophilia. Histologically, the tumor was composed of both epithelioid and spindle cells with abundant intracytoplasmic hyaline globules. These tumor cells were positive for CD21, CD23, CD35, S-100 protein, fascin and clusterin. Both epithelioid and spindle tumor cells independently colonized the liver and formed two tumor nodules 18 months after the initial resection. Notably, the two hepatic metastases additionally acquired patchy expression of human leukocyte antigen-DR. The epithelioid FDC in one of the hepatic lesions transformed into numerous bizarre giant cells, which could easily be confused with a metastatic giant cell carcinoma from the pancreas. FDC tumor should therefore be included in the differential diagnoses when dealing with a giant cell tumor.

Biomarkers, Tumor↗