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The PCB concentrations in the sebum of Yusho patients showed a site specific difference. It was higher in the sebum derived from the chest (1128.0 +/- 374.1 ng/g), the upper arm (1460.0 +/- 350.7 ng/g) and the femur (1456.0 +/- 488.5 ng/g) than from the forehead (758.0 +/- 233.7 ng/g) and the upper back skin (638.0 +/- 165.3 ng/g). To remove PCB in the sebum, a sebum-remover sheet was applied on the femur of two patients. During the four times of application, the mean amounts of removed sebun was 10.5 mg and 28.3 mg respectively. These results are unsatisfactory for practical treatment of Yusho patient. However, this approach seems to be safe and convenient and modification to collect large scale of sebum from the skin is required.
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BACKGROUND/AIMS: Facial skin is usually classified as dry, normal, and oily in the cosmetics field. However, there is no standard objective method for classifying facial skin. METHODS: We measured sebum excretion with Sebumeter at four sites on the face. Based on the amount of sebum secretion, we reclassified skin type according to the guidelines provided by the manufacturer. The mean of sebum excretion (mean facial sebum excretion; MFSE) was also calculated. RESULTS: People secrete varying amounts of sebum at different skin sites. Reclassification of skin type based on sebum secretion revealed that most participants underestimated the amount of facial sebum excretion. When sebum secretion amounts were compared, a statistically significant difference was apparent between the oily and dry skin types. However, there were no statistical differences between oily and normal, and normal and dry skin. CONCLUSION: We showed that subjective skin type does not match the amount of sebum secreted. Thus, this simple and subjective classification is of very limited use and it should be re-evaluated by using an objective and standardized measuring tool.
II alpha-Hydroxyprogesterone, a synthetic antiandrogen of low toxicity, was applied topically. In short-term experiments the sebum production of the forehead in normal male subjects was reduced significantly. The cholesterol concentration of sebum decreased to a greater extent. In long-term studies in patients with seborrhoea and male-pattern alopecia, the steroid caused a marked and constant reduction of greasiness of the hair. In this group also, the cholesterol concentration of the sebum obtained from scalp hair decreased more markedly than total sebum production. Possible effects of II alpha-hydroxyprogesterone on androgenic alopecia are discussed.
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