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At least 19 recordsLinked to original sources
PubMed1961

Studies on bacteriemia. V. The effect of simultaneous leukopenia and reticuloendothelial blockade on the early blood stream clearance of staphylococci and Escherichia coli.

Observations are presented on the course of experimental bacteriemia in rabbits modified by thorotrast reticuloendothelial "blockade" and mechlorethamine induced leukopenia, given singly and together. The production of severe granulocytopenia did not impair the clearance of staphylococci from the blood stream and did not enhance the impairment of clearance produced by thorotrast reticuloendothelial "blockade." Neither severe granulocytopenia nor thorotrast blockade alone produced consistent impairment in the removal of circulating E. coli from the blood stream, whereas when these conditions were present together, the early phases of clearance in these animals were virtually prevented. These results indicate that the host mechanisms operative in the control of bacteriemia differ for staphylococci and E. coli. It is suggested that the fate of bacteria within polymorphonuclear leukocytes may in part determine the importance of these cells in the removal of bacteria from the blood stream.

Animals↗
PubMed1961

Immunization as a factor affecting the course of septicemic anthrax.

Immunization of guinea pigs with alum-precipitated antigen increased resistance approximately 1600 times. The growth rate of Bacillus anthracis, in the septicemic phase, was the same in both normal and immunized animals; however, the number of bacilli per milliliter of blood at death was decreased by 75 percent in immunized animals. Neither the enhancement of virulence by treatment with egg yolk nor the size of the challenge dose affected the growth rate or the number of bacilli per milliliter of blood at death. Mean time to death for the treatments tested varied from approximately 20 to 100 hours. Nonimmunized animals challenged with a strain of low virulence had a terminal number of bacilli per milliliter of blood and a growth rate in the blood the same as that for the highly virulent strain

Animals↗