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At least 19 recordsLinked to original sources
PubMed1958

Studies on experimental shigellosis. I. Shigella infections of normal mice.

Experimental Shigella flexneri 3 infections produced in normal mice have been described. The passage of viable Shigella through the stomach of orally infected animals, and the persistence of the organisms in the intestine for periods of 5 to 7 days, with an increase in bacterial numbers, indicated that true infection was produced. Blood culture studies showed that a Shigella bacteriemia occurred after either oral or parenteral administration of Shigella to normal mice. Mice infected orally revealed mild, but consistent pathological changes, including mesenteric hemorrhage, liver and spleen hypertrophy, and occasional diarrhea.

Animals↗
PubMed1958

Studies on experimental shigellosis. II. The effect of fasting and fatigue on Shigella flexneri 3 infections in mice.

Host resistance to Shigella infections can be decreased by non-specific physical stress. Fasting lowers the number of Shigella required for a parenteral LD(50) dose. While the LD(50) by the oral route is larger in fasted than in nonfasted animals, the fasted host's susceptibility to oral infection is increased as evidenced by the increased fecal Shigella carrier state, duration of intestinal infection, and increased incidence of Shigella bacteriemia. Fatigue also increases the animal's susceptibility to shigellosis, but to a lesser extent than does fasting.

Animals↗