[Extragenital endocrinopathies and sterilty].
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Endocrinology↗
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An "in-production" method for testing the sterility of infusion fluids.
The addition of dehydrated broth powder to a random selection of bottles from each batch of infusion fluids before sterilization, followed by incubation of the bottles after sterilization, provides a method of sterilty testing which possesses many advantages over the traditional method of culturing small samples from bottles after sterilization.
Bacteria↗
Non-mendelian female sterility in Drosophila melanogaster: hereditary transmission of I factor.
Systematic crosses between various strains of Drosophila melanogaster lead in some cases to partly sterile F1 females. Two main classes of strains, inducer and reactive, may be recognized on the basis of the fertility of F1 female progeny. Females which may show incomplete sterilty (SF female) arise only when reactive females are crossed with inducer males, other crosses, including the reciprocal, producing only fertile F1 females. SF sterility appears as the result of an interaction between two factors, R brought into the initial cross by the reactive mother and maternally inherited, and I brought by the inducer father. The present paper reports on the hereditary transmission of I factor. It is shown that when transmitted through heterozygous males, bearing chromosomes of both inducer and reactive origin, I factor may be strictly linked to any one of the three major chromosomes of inducer strains. Such chromosomes carrying I factor were called inducer chromosomes. When transmitted through heterozygous females, this Mendelian behavior fails to hold, and non-inducer chromosomes coming from reactive strains may become inducer independently of the production of recombined gametes. This phenomenon was called chromosomal contamination. This contamination occurs even between nonhomologous chromosomes.
Animals↗
[Preparation and testing of buffered eye drops containing pilocarpine chloride with timolol maleate].
BACKGROUND/AIM: In glaucoma therapy beta-blocator, timolol-maleate, is the first-line medicine of selection, whereas a miotic, pilocarpine chloride, is one of the oldest medicines used for the treatment of this illness. They are applied as eye drops. In order to achieve a better therapeutic effect and improve life quality of the ill, we produced and tested eye drops formulations based on combining pilocarpinechloride and timolol maleate in buffers of diferent pH values. METHODS: Following the general pharmacopoeial eye drops preparation regulation, we prepared formulations, of solution type, of pilocarpine chloride and timolol maleate combination, of pilocarpine choloride alone and of timolol maleate alone. A modified phosphate buffer according to Sorensen at 7.4, 7.7 and 8.0 pH values was used as a solvent. The quality of the produced formulations was examined using physical and physico-chemical methods and biological tests. Following pharmacopoeial regulations, we examined clarity, pH value and sterilty. Pilocarpine chloride level was determined by means of ion-par (High Performance Liguid Chromatography) RP-HPLC method, whereas UV/VIS absorption spectrophotometry was used for determining the level of both timolol maleate, and timolol. RESULTS: Results showed that monocomponent and combined preparations complied with the regulation demands. With the increase in the pH value of the solution pilocarpine chloride level decreased in relation to its initial content, whereas timolol level showed a tendency of moderate increase. CONCLUSION: Magistrally prepared pilocarpine chloride eye drops with timolol maleate have satisfied all the required conditions for an ophtalmological preparation. A modified phosphate buffer according to Sorensen at 7.4 pH value proved to be the most optimal solvent.
Adrenergic beta-Antagonists↗
Clinical and biochemical experiences with danazol in the treatment of endometriosis in cases with female infertility.
Based on "second look" pelviscopic control in 438 cases of pelvic endometrosis, additional hormonal antigonadotrophin therapy with danazol represents the most effective treatment for endometriosis. The rationale is well explained by Dmowski and Scommegna (1976). As endocrine treatment alone cannot control severe cases of endometriosis, in recent years a combined 3-step surgical-endocrine-surgical therapy, with thermocoagulation of endometriotic foci, cyst wall resection of endometriomas and consecutive thermocoagulation has proved to be the optimal therapy for endometriosis in general and especially in cases of sterilty. While additional progestogen therapy resulted in a 60% rate of remission of the symptoms of endometriosis, danazol gave a 90% success rate in the 3-step therapy. This 3-step therapy avoids many cases of radical surgery during the reproductive age in women with endometriosis. The pregnancy rate of 312 patients treated between 1976 and 1978 with danazol amounted to 45% compared with a pregnancy rate of 32% treated with lynestrenol and laparoscopy.
Danazol↗