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At least 19 recordsLinked to original sources
PubMed1957

The treatment of experimental toxoplasmosis in rabbits.

Sulphadimidine alone is of little value in treating experimental toxoplasmosis in rabbits, because most rabbits acetylate the drug very rapidly. Within a short time of dosing such animals, there is little or none of the uncombined drug in the blood. In rabbits which do not acetylate sulphadimidine rapidly, relatively high concentrations of the free sulphonamide can be attained in the blood: in such animals, toxoplasmosis responds to treatment with sulphadimidine. Sulphathiazole is not acetylated so rapidly and is effective even in rabbits which acetylate sulphadimidine quickly. Pyrimethamine, even in doses as high as 50 mg. three times daily, is ineffective; dapsone is effective.

Animals↗
PubMed1957

Sulphadimidine, pyrimethamine and dapsone in the treatment of toxoplasmosis in mice.

Sulphadimidine, dapsone, and pyrimethamine have been tested alone and in various combinations for their therapeutic effect against toxoplasma infection in mice. In the treatment of active infection, sulphadimidine by itself was effective, but relapses were common. Pyrimethamine gave complete cures and prevented the carrier state when used in doses near to the toxic level. Dapsone alone was not as good as either of the other two drugs tested. The best combination was found to be sulphadimidine and pyrimethamine, which were synergic. In doses well below the toxic level, this combination not only controlled the acute infection but also prevented relapses and the development of the carrier state. Dapsone and pyrimethamine were also synergic, but were not as effective as the previous combination. No synergy was found between dapsone and sulphadimidine. The mechanism of relapse and the development of the carrier state and the modes of action of the drugs alone and in combination are discussed.

Animals↗