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At least 19 recordsLinked to original sources
PubMed2026

Gelified ethanol for percutaneous sclerotherapy of bone lesions: a systematic review of clinical applications and outcomes.

PURPOSE: To systematically review the available evidence on the feasibility, safety, and clinical effectiveness of percutaneous sclerotherapy using radiopaque gelified ethanol (RGE, Discogel®) for bone lesions. METHODS: A systematic search of MEDLINE, Embase, Web of Science, and Cochrane CENTRAL was performed. Primary studies reporting clinical, technical, and safety outcomes following RGE sclerotherapy for bone lesions were included. Data on patient characteristics, lesion type, procedural details, and outcomes were extracted and synthesized descriptively. RESULTS: Six retrospective studies involving 55 patients (mean age 22.2 ± 20.4 years; range 3-65; 26 females) with 56 lesions and 119 procedures were included (mean 2.16 procedures per patient). Aneurysmal bone cysts (80%) and aggressive vertebral hemangiomas (18%) were the main indications. Technical success was reported in 100% of procedures. Pain outcomes were available for 28 patients, with complete resolution in 64.3% (18/28), partial reduction in 32.1% (9/28), and persistence in 3.6% (1/28). Radiological follow-up (50 lesions) demonstrated complete response in 96% and partial response in 4%. No major adverse events were reported according to CIRSE (≥ 4) or CTCAE (≥ 4) criteria. One SIR grade 3 vertebral fracture occurred without confirmed causal association to RGE. Subsequent surgery was required in 3.6% of lesions. CONCLUSION: Although limited to small retrospective series, current evidence suggests that RGE sclerotherapy is a safe and effective minimally invasive option for selected benign bone lesions. Prospective comparative studies with longer follow-up are warranted.

Humans↗
PubMed1978

Varicose veins: A comparison of surgery and infection/compression sclerotherapy. Five-year follow-up.

A randomised controlled trial was carried out to compare the clinical outcome 5 years after inpatient surgery and outpatient injection/compression sclerotherapy. 91.3% of those originally treated by injection/compression sclerotherapy and 93.9% of those originally treated surgically were seen at follow-up. 40% of patients treated initially by injection/compression sclerotherapy and 24.2% of those treated surgically were given further treatment. The probability of having no further treatment is significantly greater for those treated surgically. The improved outcome after surgery increased with age, being most striking in those aged over 45. The implications of the 5-year follow-up findings for the long-term cost of treatment are discussed.

Adolescent↗
PubMed1978

Sclerotherapy of bleeding oesophageal varices by means of endoscopy.

From 1.1.1969 up to 1.11.1977, 640 patients with hemorrhage from gastro-oesopheal varices were managed by sclerotherapy of the oesophageal wall. In 90% this method succeeded in stopping hemorrhage or preventing a new bleeding during the next four months. Only 43 patients of the total number were treated because of impending hemorrhage under precise indications. After two or three sessions of sclerotherapy the interval of control can be extended up to one years without new danger of hemorrhage. Overall mortality was 14.5%; main causes of death were liver coma, uncontrollable hemorrhage, mediastinitis and pyothorax.--If liver function improves, a porto-systemic-shunt is performed whenever possible.--416 = 65% of the patients are still alive; 50% longer than one year up to eight years. Thus sclerotherapy seems to be the method of choice in uncurable massive hemorrhage from varicosities from the oesophagus. It is indicated in patients with decompensated liver function, and whenever a shunt procedure is anatomically or clinically impossible or not advisable, too.

Esophageal and Gastric Varices↗
PubMed1979

A prospective evaluation of injection sclerotherapy in the treatment of acute bleeding from esophageal varices.

In a 25 month study of massive upper-gastrointestinal hemorrhage, 64 patients were shown to have esophageal varices on emergency endoscopy. Twenty-four patients were actively bleeding from varices and were treated with a Sengstaken tube, and in 22 this was followed by emergency injection sclerotherapy using a rigid esophagoscope and general anesthesia. These 22 patients were followed prospectively and had 51 episodes of endoscopically proven active bleeding from esophageal varices which required Sengstaken tube control of hemorrhage during 36 separate admissions. This group included our total experience of injection sclerotherapy in acute variceal bleeding. The majority (14 of 22 patients) had alcoholic cirrhosis. Definitive control of variceal bleeding during the period of hospitalization was achieved in 33 hospital admissions (92%), usually with a single injection (27 hospital admissions: 75%). The results were satisfactory in 26 hospital admissions (72%). There were nine deaths (41% overall patient mortality rate), but no patient died primarily of variceal bleeding, and exsanguinating variceal bleeding was no longer a problem. The mortality rate per injection was 18%, and the mortality rate per hospital admission was 25%. Injection sclerotherapy is proposed as the emergency treatment of choice for patients with proven bleeding esophageal varices who do not stop bleeding on initial conservative treatment.

Acute Disease↗
PubMed1976

Control of distension of varicose veins achieved by leg bandages, as used after injection sclerotherapy.

A study was performed to determine whether the pressures routinely produced by bandaging for compression sclerotherapy of varicose veins are adequate to maintain the superfical veins almost empty of blood. The results suggest that well-applied bandages can provide sufficient support to combat the high distending pressures found in varicose veins. The large variation among different surgeons, however, indicates that any clinical assessment of compression sclerotherapy should include measurement of the pressure at which the bandages are applied.

Bandages↗
PubMed1978

Oesophageal function in cirrhotic patients undergoing injection sclerotherapy for oesophageal varices.

Oesophageal function has been studied in three groups of cirrhotic patients: those without varices, those with varices and those with varices treated by injection sclerotherapy. Using the Honeywell Model 31 oesophageal motility probe and the Ingold combined stomach pH electrode, measurements were made of the lower oesophageal sphincter (LES) pressure and length, swallowing responses, reflux and clearance of acid. The presence of varices was associated with an increase in LES length and reduced lower oesophageal contraction pressure during swallowing and some failure of sphincter relaxation during swallowing. Sclerotherapy was associated with a reduction in the maximum LES pressure both at rest and during swallowing, and an impairment of acid clearance, but postural reflux of acid was not observed in any patient.

Deglutition↗
PubMed1978

Technical aspects of injection sclerotherapy of acute oesophageal variceal haemorrhage as seen by radiography.

Certain aspects of the technique of injection sclerotherapy are illustrated in a series of 15 patients presenting with acute oesophageal variceal haemorrhage due to bilharzial hepatic fibrosis. The results of this form of treatment are shown. The actual process of variceal injection was done under visual fluoroscopic control, using a mixture of 76 per cent Urografin and 5 per cent ethanolamine oleate. The findings showed that: (a) the sclerosant did not reach the gastric varices which could be a possible source of re-bleeding; (b) intravariceally injected material rapidly escaped from the submucosal varices, where it should stay, to the peri-oesophageal veins; (c) sclerosant remaining on the variceal walls was minimal by the time the Sengestaken tube was inflated.

Acute Disease↗
PubMed1979

Sclerotherapy for hydrocoele and epididymal cysts.

A prospective study was carried out on the efficacy of sclerotherapy for the treatment of hydrocoeles and epididymal cysts. Thirty-six hydrocoeles and 13 epididymal cysts were treated and followed up for between 1 and 2 years. Thirty-four hydrocoeles were cured, 1 failed to respond to treatment and 1 recurred after treatment. All 13 epididymal cysts were cured.

Adult↗
PubMed1977

Injection sclerotherapy in the emergency and elective treatment of oesophageal varices.

Injection sclerotherapy with careful attention to initial diagnosis and technique is an effective way of stopping oesophageal variceal bleeding. It can also be used electively at 3-monthly intervals to obliterate varices after they have once bled. It is relatively safe and simple, but patients must be follwed up and reassessed at least every 6 months, when new varices may be injected if they occur. It is particularly suitable when the experience and facilities for emergency portacaval shunts are not available.

Emergencies↗
PubMed1979

A prospective controlled trial of sclerotherapy in the long term management of patients after esophageal variceal bleeding.

The preliminary results of the first 25 months of a prospective randomized controlled clinical trial, designed to compare repeated injection sclerotherapy with conservative medical management in the long term treatment of all patients shown to have previously bled from esophageal varices, are presented in detail. To date, 31 patients have been randomized, 15 in the chronic injection group and 16 in the control medical management group. In addition, five patients excluded for geographic reasons have been injected out of trial. Ethanolamine oleate has been injected into the varices, using a modified rigid esophagoscope under general anesthesia. The preliminary results have been encouraging. It has been possible to eradicate esophageal varices in the chronic injection group and, once the varices had been eradicated, no patient had recurrence of variceal bleeding. On the other hand, recurrent variceal bleeds have remained a continuing problem in a number of the patients in the control study. A longer follow-up period will be required to assess both the quantitative and the qualitative aspects of survival and to determine how long esophageal varices will remain eradicated as well as how frequently repeated injections will be required.

Adolescent↗
PubMedDate not supplied

[Sclerotherapy of saphenous varicose veins: some technical points].

This article concerns sclerotherapy techniques. It deals with varicosity of the large or samll saphenous veins and their treatment using sclerosing injections in cases where, for various reasons, the decision not to undertake surgery is made. The following points are successively considered: --management of the treatment: from top to bottom, that is, from the proximal to the distal segment of the varicose vein; --the dose of the sclerosing drug utilized and the relation between the amount and the concentration of the injected doses; --the position of the patient and various movements aimed at injecting the solution in a patient when he is lying down, even if the needle is introduced when he is standing up; --the spasm-inducing capacity of certain sclerosing drugs and the possible utilization of provoked veinoconstriction during treatment for better contact between sclerosing drugs and endothelium; --finally, retention with straps: they are put in place immediately after treatment, maintained from 8 to 15 days without interruption, have little or no elasticity and are non-detachable.

Humans↗