[Serum copper level and serum heat stable alkaline phosphatase in normal and pathological pregnancy].
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Alkaline Phosphatase↗
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Results for “Serum Copper Level”
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Serum copper level in gynecologic malignancies.
Serum copper level was determined before operation in 179 patients with various histologically proved gynecologic tumors: malignant, benign, or metastases to the ovary. Serum copper level was significantly higher (p less than 0.01) in all groups of patients with cancer and in the benign group when compared with control subjects. Serum copper level correlated well with stage of cancer disease (r = 0.70 to 0.79) except for ovarian carcinoma, in which serum copper level was already significantly elevated in Stages I and II. The sensitivity of serum copper level greater than 150 micrograms/dl in detecting malignancy was 87% to 100% in late cancer stages in all malignancies. Our data imply that the addition of serum copper level determination to other screening tests could increase their sensitivity.
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Cancer risk in relation to serum copper levels.
A nested, matched case-control study was conducted to assess the relationship between serum levels of copper and the subsequent risk of cancer. One hundred thirty-three cases of cancer were identified during 1974-1984 among 5000 members of a northwest Washington State employee cohort from whom serum specimens had been previously obtained and stored. Two hundred forty-one controls were selected at random from the cohort and were matched to the cases on the basis of age, sex, race, and date of blood draw. Serum copper levels were measured by atomic absorption spectrometry. Risk of a subsequent diagnosis of cancer was positively associated with serum copper levels, but only among those cases diagnosed within 4 years of the time the serum specimens were collected. Among cases diagnosed more than 4 years after specimen collection, there was no consistent association between serum copper levels and risk. Adjustment for age, sex, race, occupational status, cigarette smoking, family history of cancer, alcohol consumption, and, among females, use of exogenous hormones had no appreciable effect on these relationships. The findings suggest that the presence of cancer may increase serum copper levels several years prior to its diagnosis. They are less supportive of the hypothesis that serum copper levels affect cancer risk.
Adult↗
[Serum copper levels in early pregnancy complicated by symptoms of spontaneous abortion and infection].
INTRODUCTION: The study evaluates serum levels of copper, chorionic gonadotropin, estradiol, progesterone and prolactin in patients with symptoms of miscarriage and in uncomplicated pregnancies in cases with or without cervical or vaginal infections detected by vaginal or cervical smears, as well as Chlamydia testing. MATERIAL AND METHODS: The study included 50 patients with symptoms of threatening miscarriage and 50 patients with uncomplicated pregnancies. Hormone levels were determined by ELISA method and copper was evaluated by acid medium colorimetry. RESULTS: We found that values of serum copper, estradiol, progesterone and prolactin were significantly lower in patients with lower genital tract infection. CONCLUSION: Decreased levels of serum copper could be used as a method of choice for detecting infection during the first trimester of pregnancy.
Abortion, Threatened↗
[Serum copper levels in obesity: a study of 32 cases].
Abnormalities of copper distribution in tissues and serum has been described in obese subjects. In this prospective study, we evaluated the seric level of copper by atomic absorption in a group of 32 obese (BMI > or = 30 kg/m2) compared to a group of 32 healthy subjects. We have noted an elevation of serum copper in obese with a middle level of 133 mg/dl significantly superior to the middle level of serum copper of healthy subjects, 108 mg/dl (p < 0.001). In another hand, we have noticed that the levels of serum cooper rise with the BMI. In fact, 58.3% of the obese that have a BMI > or = 40 kg/m2 show a high concentration of serum copper although only 5% of obese with BMI < 40 kg/m2 show this high concentration. This work must be completed by the determination of ceruloplasmin levels in a larger group of obese in order to establish correlations between the serum ceruloplasmin levels, the serum copper levels and the obesity.
Adult↗
Serum copper levels in non-Hodgkin's lymphoma.
Levels of serum copper in 34 patients with adult non-Hodgkin's lymphoma at different phases of the disease have been studied. All of the patients were evaluated with complete blood counts, sedimentation rate, gallium scintigraphy, liver and bone marrow biopsies, lymph node biopsy, and laparoscopy. The level of serum copper was significantly elevated in non-responding or relapsing patients (mean 191.06 micrograms/dl), and correlated with the estimated tumor burden. Serum copper levels within normal range were found in patients in complete remission (mean 114.76 micrograms/dl). Age- and sex-matched normal controls also showed serum copper levels within normal range (mean 112.81 micrograms/dl). It is proposed that serial measurements of serum copper level may be of use in: (1) monitoring the remission status of patients with non-Hodgkin's lymphoma, (2) detecting early relapse of non-Hodgkin's lymphoma, and (3) contrary to previous reports by Hrgovcic et al., the level of serum copper seems to be related to the disease activity of histiocytic lymphoma.
Adult↗
Serum copper level in ovarian carcinoma.
Serum copper levels (SCL) were determined before any diagnostic procedure was performed or treatment given in 40 women admitted for the investigation of a pelvic mass and, later, in those patients with ovarian carcinoma after chemotherapy and before a second-look operation was performed. Patients with ovarian carcinoma were found to have significantly higher SCL than patients with benign ovarian lesions. A SCL of 150 micrograms/dl clearly separated patients with a pelvic mass on the basis of ovarian carcinoma and those with benign noninflammatory pelvic lesions. The same SCL of 150 micrograms/dl separated patients with ovarian carcinoma that responded to chemotherapy and those with residual disease. It is suggested that SCL be included as a member of the screening panel of biologic tumor markers in general and in ovarian carcinoma in particular.
Adenocarcinoma↗
Studies on copper metabolism. VIII. The correlation between the serum copper level and various serum protein fractions.
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Blood↗
Serum copper levels in users of multiload intra-uterine contraceptive devices.
The systemic absorption of copper incorporated into multiload intra-uterine contraceptive devices (IUDs), as indicated by serum copper levels in users of such devices, was assessed in a prospective longitudinal study. One hundred and ten healthy Nigerian women using either multiload copper 250 (MLCU 250) or multiload copper 375 (MLCU 375) IUDs participated in the study. Their serum copper levels were estimated serially during 12 months of continuous use of the devices. The mean (+/- s.e.m.) pre-insertion serum copper levels of our subjects using MLCU 250 (17.0 +/- 3 mumol/l) and MLCU 375 (16.7 +/- 0.5 mumol/l) were found to be lower than those reported in Americans (22.2 mumol/l) and in Germans (20.2 mumol/l), although similar to levels in Indians (17.0 mumol/l). There was no significant difference in the mean serum copper levels estimated before and after 1 month of continuous use of the device. Serial estimations of the serum copper levels in users showed that there was no alteration in these levels after a period of 12 months of continuous IUD use. We therefore conclude that the copper incorporated into multiload IUDs appears not to influence the concentration of serum copper of users.
Adult↗
Fetal and maternal serum copper levels before and during labor in normal and complicated pregnancies.
The effect of labor on maternal serum copper levels was determined in normal and complicated pregnancies. The mean value +/- SD (3.16 +/- 0.48 micrograms/ml) in 82 clinically normal subjects at term during labor was compared with that (2.22 +/- 0.49 micrograms/ml) obtained from 50 controls matched for gestational age who were not in labor. Similarly, the mean value in labor (3.56 +/- 0.46 micrograms/ml) in 25 subjects with a complicated pregnancy was compared with that (2.87 +/- 0.43 micrograms/ml) obtained from 25 similar subjects prior to labor. A statistically significant difference (P less than .001) was observed in both comparisons. Copper levels in the corresponding fetal serum from the subjects in labor (normal and complicated) were compared with those of the maternal serum samples. The mean value of fetal serum samples in mothers with complications was higher than that in normal mothers, but the difference was not statistically significant. This trend of a rise in serum copper level during labor was further confirmed by analysis of the same subject during and before labor in normal (12 subjects) and complicated pregnancies (9 subjects). Moreover, maternal serum estriol and estetrol levels were determined from the same samples in the 4 groups to find a possible relationship with the corresponding copper levels. No statistically significant correlation was noted. A possible explanation for the rise of the serum copper level with the onset of labor and its clinical implications are also discussed.
Copper↗
Analysis of zinc, iron and copper serum levels in patients with common variable immunodeficiency.
Serum zinc, copper and iron levels together with content of zinc in hair were investigated in 13 patients with common variable immunodeficiency (CVID) and in 13 controls. A significant decrease in serum zinc (mean = 11.3 mumol/l, SD = 2.9 in CVID patients compared to mean 14.3 mumol/l, SD = 2.4 in controls) and iron levels (mean = 11.8 mumol/l, SD = 3.1 in CVID patients, mean = 18.3 mumol/l, SD = 4.7 in controls) in CVID patients were observed. Hair zinc content of CVID patients was significantly decreased compared to healthy persons (1.41 mumol/g, SD = 0.64 in CVID patients, and mean = 2.23 mumol/g, SD = 0.83 in controls). Serum copper level in CVID patients was significantly increased compared to controls (mean = 24.4 mumol/l, SD = 4.8 in CVID Patients, mean = 14.6 mumol/l, SD = 2.8 in controls). The decreased serum zinc and iron levels may be caused by disturbed absorption in the intestines of patients with CVID, but redistribution due to chronic inflammatory processes is a second possible explanation of hypozincemia in CVID patients.
Adolescent↗
Serum copper levels in patients with solid tumors.
The serum copper levels were investigated in 125 patients with solid tumors: 34 patients with bronchial cancer, 35 with gastric cancer, 31 with breast cancer and 25 with melanoma. Analysis showed that serum copper was extremely high in 82% of the patients with bronchial carcinoma, while in the other examined groups no significant changes were observed. According to these results, serum copper could be a diagnostic factor in patients with bronchial carcinoma.
Adult↗
Serum copper level in non-Hodgkin's lymphomas.
Serum copper level (SCL) was studied by the atomic absorption technique in 103 patients with non-Hodgkin's lymphoma. SCL was increased in 61% of patients at diagnosis or during active disease; values within normal range were found in 88% of patients in complete remission. The difference between mean SCL during active disease and in remission was highly significant, independently of stage and histologic type, so that: a) Within the same clinical stage high SCL at diagnosis was associated with poorer response to therapy in stage II and stage III (respectively P = 0.033 and P = 0.049), but not in stage IV, where the complete remissions were only 8 out of 42. A shorter 5-year survival was also shown in stages III and IV with high SCL at diagnosis (respectively P less than 0.025 and P less than 0.05), but not in stage II where the deaths were only 3 out of 24. b) Within histologic types, SCL is a useful prognostic index of response to therapy and survival, although a statistically significant difference was only reached for poorly differentiated lymphocytic lymphoma. We conclude that SCL may be a good parameter of disease activity and a useful index of response to therapy and survival in non-Hodgkin's lymphoma.
Adolescent↗
Serum copper levels in carcinoma of ovary and cervix.
The role of serum copper level (SCL) as a diagnostic and prognostic tool in genital tract malignancies was evaluated. SCL was employed as a marker for response to treatment (surgical/radiotherapy). 129 women attending gynaecology outpatient department or admitted in the gynecology ward were studied. Of these 77 patients in the disease (study) group were proven cases of genital tract malignancies and 52 served as controls. Outcome measures studied were: SCL levels estimated before initiation of any treatment i.e. surgery/radiotherapy; thereafter, at two weeks after completion of treatment. Follow up of the study subjects was done between 4-8 weeks and 8-10 weeks, when the patients were evaluated for any recurrence of disease and SCLs were also estimated. Kruskal-Wallis one-way analysis of variance determined whether values varied significantly among the different groups studied. Mean SCLs were found to be significantly elevated in cases of Ca ovary (n = 15), early CaCx (n = 14) and late CaCx (n = 48), as compared to the control group, comprising of women with no signs and symptoms of malignancy (n = 52). SCLs decreases significantly (P < 0.001) after treatment of Ca ovary and CaCx. These results indicate a possible clinical usefulness of estimating serum copper levels in women with genital tract cancer and suggest a role for SCL in the evaluation of the disease activity and as a prognostic tool in the management of genital malignancies.
Adolescent↗
Serum copper levels in patients with lung cancer.
An increased mean serum copper level was found in 149 patients with lung cancer when compared with 19 healthy people and 23 patients with non-malignant lung diseases. The level seemed to reflect the stage of disease, with asymptomatic patients showing the lowest values, and patients with metastatic symptoms the highest. In spite of significant differences between the groups of subjects the scatter in the values was large. Hence serum copper determinations can be of only limited importance for differential diagnosis or in assessing the clinical stage of cancer. No differences in copper levels were found between the groups of patients with different histological types of lung cancer.
Adenocarcinoma↗
Serum copper levels and not zinc are positively associated with serum leptin concentrations in the healthy adult population.
Leptin, the obesity gene protein product, is a hormone with multiple physiological functions in the human. However, there are few reports in the literature on its role in trace element metabolism in the normal population. Therefore, we investigated the association among serum leptin, zinc, copper, and zinc/copper ratio in 570 healthy men and women aged 15 yr and older. Serum leptin assay was done with a commercial enzymelinked immunosorbent assay kit; serum zinc and copper levels were measured by an atomic absorption spectrophotometer. Serum leptin was found to be positively associated with age (r=0.254, p<0.001), sex (r=0.406, p<0.001), body mass index (BMI) (r=0.553, p<0.001), and serum copper (r=0.419, p<0.001), but negatively associated with the zinc/copper ratio (r=-0.423, p<0.001). There was no significant association between serum leptin and zinc (r= -0.131, p>0.05). When the confounding effects of age, sex, and BMI were removed, serum leptin was still positively associated with serum copper (r=0.197, p=0.02) and the serum zinc/copper ratio (r=-0.182, p=0.03). These results suggest that copper and not zinc has an effect on serum leptin levels.
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Serum copper levels among a tribal population in Jharkhand State, India: a pilot survey.
BACKGROUND: Copper is an essential trace element that plays a pivotal role in cell physiology. Dietary intake of copper by a population of low-income groups in India has been found to be low, and hence the possibility of dietary copper deficiency exists. OBJECTIVE: To determine serum copper levels among tribal populations in India, an area in which data are limited. METHODS: The study was conducted among tribal populations 18 to 75 years of age residing in Sahibganj, Jharkhand. Two blocks in the district were selected (from a total of eight) for the detailed study. A semistructured pretested questionnaire was used to collect demographic and socioeconomic information about subjects. A total of 995 subjects were enrolled for the present study. Blood was drawn from the antecubital vein and collected in previously labeled polypropylene tubes. Serum copper was determined by the atomic absorption spectrophotometry method and serum samples with copper levels less than 80 microg/dL were considered to have low serum copper levels. RESULTS: The mean serum copper concentration of the study subjects was 91.18 +/- 35.48 microg/dL. Thirty-four percent of the study subjects had low serum copper levels (< 80 microg/dL). Nearly 35% of males and 34.4% of females had low serum copper levels. CONCLUSIONS: This study documented a high prevalence of low serum copper levels among the studied tribal population. Further multicenter studies with larger sample sizes are needed to assess the biological implications of copper deficiency among the tribal populations in India.
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Changes in serum copper level during detoxification of acutely poisoned drug addicts.
Although it is known that drug addicts are a high-risk group for disruption of many homeostatic processes, little is know about changes in serum trace elements concentrations after taking the psychoactive substances. The aim of the study was to check the influence of the taking homemade heroin on serum level of copper. Blood samples were taken from 30 opiate addicts, and copper concentrations were measured by the means of atomic absorption spectrophotometry. The result of the study show that in the examined group, copper serum concentrations (1.35 mg/L) upon admission to the clinic were higher than in the control group (1.11 mg/L) but decreased during hospitalization (1.18 mg/L). There was no correlation between duration of stay at the hospital and changes in serum copper concentration.
Adolescent↗