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Medial preoptic area kindling induces sexual behavior in sexually inactive male rats.

In the present experiments, sexually experienced and non-copulating male rats were kindled in the medial preoptic area (MPOA) or the amygdala (AMG) with the purpose to investigate if the widespread modification of brain function produced by kindling induces sexual behavior in non-copulating rats and if kindling facilitates sexual behavior in copulating rats. Since kindling in the MPOA has been little studied, a description of this phenomenon is also presented. The animals were stimulated 4 times daily on odd days and sexual behavior monitored on even days. The results showed that the MPOA required higher stimulus intensity to elicit an afterdischarge (AD) than the AMG. The AD duration was significantly longer in animals kindled in the MPOA than in animals kindled in the AMG. No difference was found in the development of kindling between these brain structures. Kindling had no effect upon sexual behavior in copulating rats. In contrast, MPOA kindling induced copulation in non-copulating male rats. Seven out of 9 animals displayed sexual behavior. No significant facilitation was observed after AMG kindling in non-copulating male rats. Furthermore, the sexual behavior displayed by the previously non-copulating MPOA kindled rats was similar to the sexual behavior displayed by sexually experienced animals. It is proposed that sexual behavior is facilitated in these male rats by local neural changes produced by kindling.

Animals

Differential rates of exhaustion and recovery of several parameters of male rat sexual behavior.

Sexual exhaustion of the male rat was studied with respect to several copulatory measures. The ejaculatory latency, intercopulatory interval, and intromission frequency demonstrate a U-shaped curve, exhibiting high values for the initial ejaculatory series, falling to a minimum at an intermediate ejaculatory series, and again increasing at exhaustion. The absolute refractory period of the postejaculatory interval (measured at vocalization termination) increases linerly, whereas the relative refractory period (the remaining portion of the postejaculatory interval) is a postively accelerating function. Partial recovery tests demonstrated that the preejaculatory measures and absolute refractory period have substantially returned to baseline values by Day 6, while the relative refractory period is still extended. The significance of these data to the theoretical modeling of sexual behavior is discussed.

Animals

Sexual behavior and sexual orientation of the female rat after hormonal treatment during various stages of development.

The amount of circulating sex steroids during Postnatal Days 30-90 was varied in normally developed and in androgenized female rats. The influence of these manipulations on sexual behavior and sexual orientation was investigated. Normally developed or neonatally androgenized females were ovariectomized and implanted with estradiol through Postnatal Days 30-90 or sham-implanted. The remaining subjects were left intact during that period. The hormonal condition during Postnatal Days 30-90 significantly affected the behavior of normally developed females, but affected the behavior of neonatally androgenized females only to minor extent. Estrogen implants in normally developed females enhanced masculine sexual responses and induced a female-directed sexual orientation. Feminine sexual responses were unaffected by this treatment. Sham-implanted, normally developed females showed a male-directed sexual orientation and fewer masculine sexual responses than subjects which were left intact during Postnatal Days 30-90. Neonatal androgen treatment in general resulted in elevated levels of masculine Neonatal androgen treatment in general resulted in elevated levels of masculine sexual responses, inhibited feminine sexual behavior, and facilitated a female-directed sexual orientation.

Animals

The relation between sexual activity among children during preadolescence and/or early adolescence and sexual behavior and sexual adjustment in young adulthood.

This study examined whether current sexual behavior and sexual adjustment in a sample of 433 college students differed as a function of having engaged in sexual activity with other children during preadolescence (prior to age 13) and/or early adolescence (ages 13-15). Four groups were compared: subjects who only had an early adolescent sexual experience; subjects who had both preadolescent and early adolescent experiences; subjects who had no sexual experience with another child during either preadolescence or early adolescence. There were no significant differences between these groups on measures of incidence of premarital intercourse, age at first intercourse, number of different intercourse partners, sexual satisfaction, sexual arousal, or sexual dysfunctions. It was concluded that in general the simple occurrence or nonoccurrence of sexual activity among children during these developmental periods has little impact, either positive or negative, on later sexual adjustment during young adulthood. Some expections, depending on the specific types of childhood sexual activity involved, were noted.

Adaptation, Psychological

Sexual behavior and sexually transmitted diseases among Swedish university students.

Students at Uppsala University, Sweden, were interviewed about their sexual behavior, their knowledge of and attitudes to sexually transmitted diseases (STDs) and related issues. The purpose of the study was to ascertain trends in behavior and attitudes as an indication of the likely risk of the spread of STDs, in particular AIDS, among students. Results revealed that change of partner was commonplace. A significant number of students had suffered from an STD. Students' claims that their own sexual practices, and those of others, had changed as a result of the AIDS epidemic, proved to be unsubstantiated in their behavior. Although contraceptive use was high, condom use with change of partner was infrequent. Alcohol played a significant role in impairing judgement. Despite a reasonably sound knowledge of STDs, the students exhibited a high degree of risk-taking behavior. The study has highlighted the dichotomy between knowledge and practice in student sexual behavior. Notable was the lack of perception among university students of their own risk of contracting STDs.

Acquired Immunodeficiency Syndrome

AIDS knowledge and beliefs, and sexual behavior of sexually delinquent and non-delinquent (runaway) adolescents.

This study assessed general knowledge of AIDS, beliefs about preventing AIDS, and sexual behavior among two groups of male adolescents at high risk of HIV/AIDS: 60 sexually delinquent males and 57 non-delinquent runaway males. Significantly fewer sexually delinquent than non-delinquent (runaway) males had experienced sexual intercourse with a consenting female partner (45 vs. 89 per cent). Sexually delinquent youths scored significantly lower than non-delinquent youths in general knowledge of AIDS (65 vs. 73 per cent) and were not able to discriminate safer behaviors from those which were less safe (42 vs. 71 per cent). Both groups reported moderate support for beliefs about preventing AIDS. These results suggest HIV/AIDS prevention programs that attempt to increase knowledge are needed by these youths, particularly for sexually delinquent youths.

Acquired Immunodeficiency Syndrome

Differences in biologic maturation, sexual behavior, and sexually transmitted disease between adolescents with and without cervical intraepithelial neoplasia.

Because several cofactors may influence the development of cervical intraepithelial neoplasia (CIN) in young women, we compared differences in behaviors (sexual activity, contraception, and cigarette use), sexually transmitted disease (STD) infection rates (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and herpes simplex virus), and cervical maturation (age of menarche and percentage of cervical ectopy) in groups of sexually active female adolescents with and without CIN. Those with CIN were compared with three non-CIN groups: (1) teenagers who were referred to a teen colposcopy clinic but had no evidence of CIN (high-risk group), (2) teenagers seen at a gynecology clinic without STD symptoms (asymptomatic group), and (3) teenagers seen at the gynecology clinic with STD symptoms (symptomatic group). The percentage of cervical ectopy was measured by colpophotography. Subjects with CIN had more lifetime sexual partners than the asymptomatic group (p less than 0.001) and were more likely to smoke cigarettes than either gynecology clinic group (p less than 0.01). No differences in behaviors existed between the CIN and high-risk groups. The mean age of menarche in those with CIN was 1 year older than all three non-CIN groups (p less than 0.05), and those with CIN had a greater area of ectopy than those without CIN (p less than 0.02). Those with CIN were more likely to have a past or present history of C. trachomatis infection than the two gynecology clinic groups; no difference was found between the CIN and high-risk groups. We conclude that cofactors such as smoking, sexual promiscuity, and C. trachomatis infection may influence cervical vulnerability. However, cervical biologic immaturity is an important risk factor for development of CIN in adolescent girls.

Adolescent

A survey of knowledge about AIDS and sexual behavior in sexually active men in Mae Sot, Tak, Thailand.

A survey of 15-34 year old men in Mae Sot, Tak, was conducted in December 1989 to determine their knowledge about AIDS, HIV transmission, and sexual behavior to guide future AIDS prevention programs. A total of 172 men from the municipality (urban) and 311 men from the surrounding villages (rural) were interviewed. More than 90% of both groups possessed knowledge about the existing modes of HIV transmission, however, there were some who had the mistaken belief that AIDS can be spread by mosquito bites, using public toilets, or through various forms of casual contact. These misconceptions in the community underscore the need for more education designed to counteract them. Although nearly all of them knew that condoms can prevent infection, only half of the urban and one-third of the rural sexually active men had ever used a condom during their sexual intercourse with prostitutes. However, condom use increased over time. Since a number of these men first engaged in sexual intercourse at an early age, the promotion of health education about AIDS in the schools is essential.

Acquired Immunodeficiency Syndrome

Zona incerta lesions: effects on copulation, partner-preference and other socio-sexual behaviors.

Sexually active males prefer a sexually receptive female to a non-receptive female, and partner-preference tests provide one way of studying the effect of brain damage on sexual motivation. Male rats with bilateral electrolytic lesions of the caudal zona incerta do not mate, and we studied the effects of zona incerta destruction on copulation and partner-preference. Lesioned males did not mate but were not indifferent to sexually receptive females. They continued to show a strong preference for a sexually receptive female over a non-receptive female. In addition, lesioned males showed many incomplete mounts i.e. mounts not accompanied by the pelvic thrusting necessary for intromission and ejaculation. Anogenital investigation of the receptive female was common. Taken together, these facts suggest that zona incerta destruction eliminates copulation without affecting sexual motivation, and that the failure to mate after lesioning probably reflects an inability to properly engage the locomotor responses of copulation.

Animals

[Psychological stress and sexual behavior in male rats. I. Sexual behavior in rats undergoing psychological or physical stress].

The relationship between sexual behavior and long-term stress in male Wistar rats was investigated. Rats were divided into two groups, one of which exposed to electrical foot shock for 1 hour a day for 10 weeks to create physical stress. The other group was exposed to the rats receiving shock to create psychological stress. Rats in both groups were placed in a compartment with a floor grid from which the foot shock might be derived. Rats in the psychological stress group were prevented from receiving foot shock by a plastic plate placed on the floor, but they were exposed to the response of the rats receiving foot shock. Sexual behavior tests were done 2, 4, 6, 8, and 10 weeks after starting the induction of stress. Rats in the physical stress group increased their sexual activity with exposure to long-term physical stress. On the other hand, rats in the psychological stress group temporarily increased their sexual activity, but then their sexual activity gradually decreased. Our experimental results suggest that long-term psychological stress reduces the sexual activity of male rats.

Animals

LHRH and mating behavior: sexual receptivity versus sexual preference.

Sexual behavior and sexual preference measurements were obtained from ovariectomized female rats treated with estrogen, estrogen and progesterone, or estrogen followed by third ventricular infusion of luteinizing hormone releasing hormone (LHRH) or saline. The lordosis-to-mount ratio and the occurrence of receptive and proceptive behaviors were scored to assess total sexual receptivity. Sexual preference was determined by placing the test female in the center of a four-winged choice box apparatus in which each of the outer wings contained one of the following incentive animals: a sexually active male (SM), a castrate male (CM), a female in proestrus (PF), and an ovariectomized female (OF). Time spent in close proximity to the incentive animals was measured as an index of sexual preference. Estrogen and progesterone treatment resulted in high sexual receptivity and a marked preference for SM. Estrogen alone or in combination with saline also produced a significant preference for SM. Animals treated with estrogen and LHRH exhibited high levels of sexual receptivity compared to estrogen saline treated controls, but no enhancement of preference for SM was detected. The results indicate that fractionation of sexual receptivity and sexual motivation occurs following estrogen-LHRH treatment.

Animals

[A study on the relationship between pre- and post-hysterectomy sexual behavior differences and the sexual satisfaction of women who have had a hysterectomy].

The objective of this study was to provide a basis for sexual counselling and education for women who have had a hysterectomy. This was a cross sectional descriptive correlation study. There were 230 subjects in the study. The time period from the hysterectomy varied from one month to eighteen months. The subjects were selected by a convenient sampling method. The tool for this study was developed by the researcher through a literature review, consultation from 36 women who have had a hysterectomy and nursing faculty. A pilot study was done to determine the necessary modifications. Data collection was done between Sept. 1987 and Dec. 1987 using a mailed questionnaire. The results of this study are summarized as follows; 1. The differences between pre-post hysterectomy sexual behavior in frequency was that all the sexual behaviors were decreased; the decreased rate of coitus was 20.7%, of kissing or embracing 10.9%, of fondling of sexual organs 8.7%, of female prone-position 3.3%, of petting 7.7%, of sexual day dream 1.0%. 2. For the low income group, the sexual behavior with the most significant decrease in frequency was fondling the sex organs (t = 2.21, p less than .05). For the housewife group, it was a decrease in the one of the female prone position (t = -2.02, p less than .05). For the group under the age of 39, it was petting (t = -2.13, p less than .05). The housewife group showed an increase in sexual day dreams as compared to the group having a job (t = -3.12, p less than .01). The group that did not received the post-op information, showed a significant decrease in kissing or embracing behavior (t = 2.73, p less than .01), and male prone position (t = -2.46, p less than .01), and also the group that did not receive the pre-op information showed a significant decrease of male prone position (t = -2.19, p less than .05), and also of petting (t = -2.95, p less than .01). 3. The relationship between sexual behavior pre-post hysterectomy differences and sexual satisfaction only showed a significant correlation for the sexual behavior of coitus (r = -2.012, p less than .001), and fondling of sex organs (r = -.1121, p less than .05). In conclusion, although there were a decrease in all sexual behavior after the hysterectomy, the difference between the pre hysterectomy sexual behavior and the post hysterectomy sexual behavior correlated with sexual satisfaction for only of the two behaviors.

Coitus

The role of mesencephalic tegmentum in regulating female rat sexual behaviors.

Feminine sexual behaviors were tested in estradiol benzoate (EB) and progesterone (P) primed ovariectomized rats following four types of radiofrequency lesions in the midbrain tegmentum. The dorsomedial lesion (DML) which destroyed the ventromedial central gray including the dorsal raphe nucleus and adjacent area induced high sexual receptivity in the females primed with low dose (0.5 micrograms) of EB-P. All females with DML exhibited lordosis and ear wiggling, the mean lordosis quotient (LQ) being significantly higher than that of castrated controls or sham operated rats. Sexual receptivity in females with ventromedial tegmental lesion was not significantly different from those of the control and sham groups. In contrast to the medially lesioned groups, the mean LQ was low in the animals with bilateral lateral tegmental lesions even when the dose of EB was increased to 2 micrograms which was sufficient to induce high sexual receptivity in castrated and sham operated control females. In the animals with dorsolateral tegmental lesions (DLL), a much more severe loss of lordosis was seen than in those with ventrolateral tegmental lesions (VLL). None of the DLL females displayed sexual behavior throughout the present experiments. These results lead us to conclude that the midbrain dorsomedial tegmental area (ventral central gray and the adjacent area) is concerned with female sexual behavior inhibiting system, whereas the lateral tegmental area may be involved in the facilitatory system.

Animals

Sexual behavior in the cockroach genera Periplaneta and Blatta. III. Aggression and sexual behavior.

Relationships between aggression and sexual behavior were examined in 6 cockroach species (genera Periplaneta and Blatta) in a descriptive manner. Aggressive encounters were classified according to intensity level. The behaviors themselves were scrutinized for differences according to varying contexts such as food and water deprivation and sexual situations. Sexual and species differences in aggressive behaviors were analyzed. Sexual encounters in cockroaches are considered as conflict situations in which many of the sexual behaviors of male male serve to neutralize aggressive behaviors of the female. Major adaptations include a male pheromene, tergal glands and defensive manoeuvering with body and legs.

Aggression

Olfactory bulb removal decreases androgen receptor binding in amygdala and hypothalamus and disrupts masculine sexual behavior.

In these experiments we examined the relationship between olfactory bulb removal, limbic system androgen receptor binding and male copulatory behavior. Sexually experienced male rats were castrated, and implanted with two 10 mm testosterone-filled silastic capsules. Animals then underwent either bilateral olfactory bulb removal (BOB) or sham surgery (Sham). Beginning 1-2 days postoperatively both BOB and Sham operates were given 4 tests for male copulation on alternate days. Less than 40% of BOB males ejaculated. In contrast, 80-100% of sham operates continued to ejaculate throughout the 4 postoperative tests. Cell nuclear androgen receptor binding was assessed in amygdala, hypothalamus, preoptic area and septum 1-2 and 8-9 days after either bulbectomy or sham surgery. We found that olfactory bulbectomy significantly reduces androgen receptor binding in amygdala and hypothalamus. The reduction in androgen receptor binding in amygdala occurs within 1-2 days following olfactory bulb removal and is correlated with the disruption of ejaculatory activity. These data suggest that the neuromodulation by olfactory bulb input to androgen-concentrating neurons in the amygdala and hypothalamus is necessary for effective copulation in male rats.

Amygdala