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At least 19 recordsLinked to original sources
PubMed1995

Kinetic study of release of silicon compounds from polysiloxane tissue expanders.

The release behavior of typical commercial tissue expanders has been examined by carrying out two kinds of experiments: 1) Determination of chemical nature and its modification after in vivo use by X-ray photoelectron spectroscopy for chemical analysis. This study has been paralleled by scanning electron microscopy with associated energy dispersive X-ray analysis of surface, as well as by silicon compounds analysis of tissues around implants. 2) Kinetic examination of silicon compounds released by the biomaterial in physiologic solution at 36 +/- 0.3 degrees C. Results of these investigations have shown independently that the starting material was not a filler-free, pure polymer, but a composite, reinforced elastomer, with the reinforcing agent most seemingly represented by silicon dioxide. Release of latter, with a relatively fast kinetics, is compatible with data of the simulating laboratory runs in the physiologic solution. All these facts seem to rule out any hypothesis of a prevailing siloxane oligomer migration. The correlation of kinetic and physicochemical tests with the in vivo behavior is discussed.

Chemical Phenomena↗
PubMed1984

Silicon compounds as substrates and inhibitors of acetylcholinesterase.

Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis.

Binding, Competitive↗
PubMedDate not supplied

[The balneotherapy importance of the silicon compounds in siliciferous waters when used externally].

Bath therapy was assigned to 300 patients with primary hypothyroidism, chronic venous insufficiency of the legs, neurologic symptoms of lumbar osteochondrosis. Fresh, siliceous, siliceous carbon-dioxide and carbon-dioxide waters were tested comparatively. It is reported that siliceous baths with threshold silicon compounds concentration 50 mg/l had the effect similar to that of fresh-water baths. Indications have been specified for introduction of carbon dioxide and siliceous carbon dioxide baths in the diseases studied.

Baths↗
PubMed1995

Wegener granulomatosis is associated to exposure to silicon compounds: a case-control study.

Wegener granulomatosis is a rare disease of unknown aetiology. In the majority of these patients the kidney is involved in the disease process. We performed a case-control study to evaluate the role of occupational exposure in the development of Wegener granulomatosis with renal involvement. The occupational histories of 16 cases with clearly established diagnosis of Wegener granulomatosis with renal involvement were compared with those of 32 age- and sex-matched controls. It was observed that inhalation of silicon-containing compounds such as silica and grain dust gave a nearly sevenfold risk for Wegener granulomatosis. Further epidemiological and experimental work needs to be performed in order to corroborate these findings.

Adult↗
PubMed1970

Renal damage associated with silicon compounds in dogs.

A number of oral preparations of various forms of silicon were fed to young adult Beagle dogs and young rats of both sexes for a period of four weeks. During the test period the animals were observed for clinical symptoms and urine and blood measurements were made. At the end of the experimental period all animals were sacrificed and subjected to a complete necropsy and histopathologic study. Polydipsia, polyuria, and soft stools in some animals fed sodium silicate and magnesium trisilicate were the only untoward clinical signs observed; all clinical tests on blood and urine were within normal limits. Gross and microscopic renal lesions were observed in dogs fed sodium silicate and magnesium trisilicate but no changes were seen in those animals fed silicon dioxide or aluminium silicate. Lesions were not observed in any of the rats. In view of the large number of commercial preparations which contain sodium silicate and magnesium trisilicate used in human medicine, these compounds deserve further study.

Aluminum Silicates↗