[The significance of physiological and biochemical deviations from the norm on the skin surface for infectious skin diseases (proceedings)].
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The efficacy and tolerance of Cefazedone, a new Cephalosporin derivate, were investigated in an open clinical trial on 40 patients with bacteriological skin infections. Patients with Erysipelas, impetiginized dermatoses and Pyodermia were treated during an average period of 9 days mainly with a dosage of 2X1 g i.v., in some cases with 2X2 g i.v. daily. The success of the treatment was good--very good in 92% of the cases. All pathogens isolated before treatment (Streptococci, St. aureus, E. coli) were eliminated after treatment. 2 patients showed transitory incompatibility reactions due to too rapid injections. The local and systemic tolerance were excellent in all other cases. 1 hour after i.v. injection of 1 g Cefazedone to 20 patients the mean concentration in the serum was 51 micrograms per ml and in the skin-tissue 10.6 micrograms/g.
A unilateral vesiculobullous eruption associated with fever was seen on the neck, shoulder, and upper part of the chest of a 7-year-old boy. Although three dermatomes in all were involved, the lesions resembled herpes zoster. The patient had had varicella in infancy. Culture of fluid from several bullae yielded echovirus 6; however, and serum neutralizing antibody to this virus rose in titer from 1:32 to 1:640. It is suggested that echovirus 6 and other enteroviruses may cause a number of vesicular eruptions that resemble herpes zoster and similar infections. Viral culture, while often difficult to obtain, is the only way to identify the cause of eruptions like this one.
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Brief descriptions are given of the common skin diseases in aquarium fishes. Many of these diseases are secondary to poor water quality and aquarium conditions and this primary cause should always be considered.
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This discussion has highlighted some of the cutaneous disorders that are found in football and wrestling participants in an exaggerated form. These disorders may occur in any person, of course, and are not limited to football or wrestling participants. Also, football and wrestling participants may have any cutaneous disorder; their disorders are not limited to those mentioned in this review. The dermatologist should be alert to contagous disorders in these participants, especially because of the close contact their activities necessitate and the potential epidemic spread of these disorders. One must also be alert to the possibility that a condition may be masked by the minor trauma of the sport. It is re-emphasized that these disorders are exaggerated because of the increased perspiration, heat, friction, secretion of fatty acids, body contact, special gear, climatic conditions, and trauma. Fortunately, the participants are normally healthy individuals who respond quickly to the appropriate therapy.
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A 24-year-old woman had massive purulent and verrucous vegetations with fissuring in the groin and axillae. She also had scaling, crusted, bullous, and purulent lesions on the scalp, face, axillae, umbilicus, groin, and hands. Biopsy specimens of skin for histopathologic examinations and direct immunofluorescent study showed typical bullous pemphigoid, and serial serum samples tested by indirect immunofluorescent study confirmed the diagnosis. A basement membrane antibody was presented on four occasions at titers of 320, 1,280, 169, and 320. The differential diagnosis included dermatitis vegetans and pemphigus vegetans. An appropriate term for this manifestation of bullous pemphigoid is "pemphigoid vegetans."
A boy, aged 18 months, presented with bullous chickenpox due to simulutaneous skin infection with varicella and staphylococci. Two strains of staphylococci phage type II were identified. The child was treated with strict asepsis and antistaphylococcal therapy. Systematic steroids are contra-indicated.
The interrelations between environment-factors, especially microorganisms (fungi, bacteria and viruses) and human skin are discussed. Besides different local disturbances of the skin, the following ways of sensitisation are explained. It is pointed out that new drugs and/or substances must be tested before they can be used in human skin. The most frequent parasites and skin diseases caused by these and their epidemiological situations are mentioned.
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Geriatric patients, though they may present many of the dermatological problems occurring throughout adult life, show a greater incidence of the degenerative skin changes consequent on sun exposure in the form of collagen degeneration, solar keratoses, keratoacanthoma and skin cancer. The benign, precancerous and malignant skin tumours, the various types of eczema, senile pruritus and certain other conditions will be discussed.