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Results for “Spinal Cord Neoplasms”

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At least 19 recordsLinked to original sources
PubMed1977

Treatment of experimental spinal cord compression caused by extradural neoplasms.

Epidural spinal cord compression was produced in rats by injection of Walker 256 carcinoma cell suspension anterior to the T-12 or T-13 vertebral body. The tumor grows through the intervertebral foramina to compress the spinal cord and produce paraplegia in 3 to 4 weeks. The effect of several treatments upon clinical signs was assessed. Dexamethasone caused a significant but transient improvement in neurological function. Radiation therapy likewise improved neurological function, and was more effective when given by a high-dose protracted course than when given either in a single dose or a low-dose protracted course. Laminectomy was not helpful in relieving neurological symptoms. Dimethyl sulfoxide did not relieve neurological symptoms. Cyclophosphamide was most effective in relieving neurological symptoms, and most of the animals that were treated with that drug when they were severely weak but still able to move their hind limbs recovered fully. Some animals that were totally paraplegic when treatment began recovered function after radiation therapy or cyclophosphamide treatment, but recovery was better if treatment was started when animals could still move their hind limbs. This animal model appears to be a useful way of studying the treatment of human spinal cord compression produced by epidural neoplasms.

Animals↗
PubMed1976

Neoplasms of mesenchymal origin in the spinal cord and nerve roots of three dogs.

Clinicopathological findings of three different neoplastic conditions involving the spinal cord and nerve roots in three dogs are described. One sarcomatous intra-medullary tumor closely associated with the vasculature was classified as a reticulum cell sarcoma of the spinal cord. The second case had massive and widespread neoplastic proliferation of reticulohistiocytic cells around the perineurinal vessels of many spinal nerve roots. The process was classified as a primary neoplastic reticulosis of the spinal roots. Multiple highly malignant tumors, infiltrating the spinal cord were found in one thoracic and several lumbosacral spinal nerve roots in the third case. These were considered to be anaplastic neurofibrosarcomas because of high collagen content, intact nerve fibers, whorl formation, and the tendency to palisade in some areas.

Animals↗
PubMed1978

Meningeal sarcoma of the spinal cord in a newborn.

In a newborn infant, spinal rigidity and signs of cervical cord compression developed. Myelography suggested the presence of a spinal cord neoplasm, and pathologic studies confirmed the diagnosis of a pleomorphic cellular sarcoma originating from the leptomeninges of the thoracic spinal cord. A review of neonatal spinal cord neoplasms disclosed a high incidence of developmental tumors in this age group and, therefore, the need for early diagnosis, since many of these tumors are amenable to radiation therapy and surgical removal.

Female↗
PubMed1976

[Metastatic carcinoma involving the cauda equina].

The case of a 60 year-old man who had an indifferenciated carcinoma in the lung is reported. He had received cobaltotherapy and had improved. After 3 months a lumbar pain had began and the patient was hospitalized. A myelography with lipiodol demonstrated and intra-dural mass. At operation a big intra-dural tumor including the cauda equina was found. The microscopic examination revealed an undifferenciated carcinoma, that inflitrated the epi and peri-nerual space.

Cauda Equina↗
PubMed1978

Intradural sacral nerve root metastasis mimicking herniated disc. Case report.

Spinal tumors may mimic herniated discs but the neurological findings and radiographs usually indicate the correct diagnosis. A case of metastasis to the S-1 intradural nerve rootlets is reported, with symptoms closely simulating a herniated disc. The correct diagnosis could not be made preoperatively in spite of clinical suspicion of a tumor.

Adenocarcinoma↗
PubMed1978

Diagnostic value and limitations of selective spinal angiography in different lesions of the vertebral bones.

The technique, diagnostic results and significance, differential diagnostic considerations and limitations of selective spinal angiographies in chronic inflammatory processes (Pott's disease 11 cases). hemangiomas (21 cases) and aneurysmal bone cysts (9 cases) as well as benign and malignant tumors (26 cases) of the vertebral bones and adjacent tissues are described and demonstrated with regard to radiological findings.

Adolescent↗
PubMed1979

Spinal computed tomography: limitations and applications.

A comprehensive review of 188 spinal computed tomography (CT) scans done over a 9-month period was performed to establish both the shortcomings and applications of the technique. The value of intrathecal enhancement was reviewed in an attempt to establish indications for its use. The data base comprised 51 abnormal scans including cases of spinal trauma, dysraphism, intra- and extraspinal neoplasm, and spinal stenosis. Results indicate that: (1) the introduction of intrathecal contrast media greatly extends the morphologic capabilities of spinal CT in practically all cases where altered anatomy of the spinal canal and its contents is suspected; (2) conventional screening procedures such as plain films of the spine and myelography should be obtained prior to spinal CT in most cases because of their value in defining the location and longitudinal extent of the pathologic process; (3) spinal CT examinations tailored to specific areas of interest result in better characterization of traumatic, dysraphic, and stenotic conditions conceivably leading to better surgical management and more accurate prognosis. At present, spinal CT has its greatest diagnostic usefulness in the evaluation of trauma and its sequela.

Constriction, Pathologic↗