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Results for “Splenic Artery”

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At least 19 recordsLinked to original sources
PubMed1979

Effect of prostaglandin E2 on vascular reactivity to norepinephrine in isolated rat mesenteric artery, hind limb and splenic artery.

The effects of prostaglandin E2 (PGE2) and indomethacin on the vascular reactivity to norepinephrine were tested in three different isolated rat vascular beds (mesenteric artery, hind limb and splenic artery) perfused with the Krebs bicarbonate solution. In these vascular beds PGE2 (0.1-64 ng/ml) or indomethacin (09.1-96 microgram/ml) in the perfusate did not change the basal pressure. In the mesenteric vascular bed and the hind limb, PGE2 dose-dependently potentiated the vascular response to norephinephrine, whereas PGE2 dose-dependently inhibited the vascular response to norepinephrine in the splenic artery. In these three vascular beds indomethacin in the perfusate dose-dependently attenuated the vascular response to norepinephrine. In the mesenteric artery and the hind limb PGE2 restored the effect of indomethacin, but in the splenic artery PGE2 did not restore the inhibitory effect of indomethacin. These results indicate that the modulating effect of exogenously administrated PGE2 on the vascular action to norepinephrine varies in different vascular beds. It is also suggested that the contribution of endogenous PGE2 synthesized in the vascular wall to the vascular reactivity to norepinephrine is, as well as the effect of exogenous PGE2, different in different vascular beds.

Animals↗
PubMed1979

Presplenectomy transcatheter occlusion of the splenic artery.

Transcatheter splenic artery occlusion can be performed rapidly and safely prior to splenectomy. This procedure reduces splenic bulk and decreases intraoperative bleeding. Patients not operated on after transcatheter splenic artery occlusion have had high mortality, and therefore the procedure should probably not be considered unless splenectomy is contemplated. An illustrative case is reported.

Adult↗
PubMed1977

[Splenic arterial aneurysm rupturing into the splenic vein. A rare cause of acute fortal hypertension in the post-partum period (author's transl)].

Following the sudden onset of a clinical syndrome of acute portal hypertension in a young woman in the course of childbirth, angiography revealed a voluminous aneurysm of the splenic artery rupture into the splenic vein. Surgical treatment was successful. The authors review the main characteristics of splenic arterio-venous fistulae and discuss the physiopathological problems of portal hypertension associated with such lesions.

Adult↗
PubMed1979

Hemosuccus pancreaticus secondary to ruptured splenic artery aneurysm.

A case is presented of a ruptured splenic artery aneurysm communicating with the main pancreatic duct which resulted in obscure upper gastrointestinal bleeding. Bipolar ligation of the splenic artery and excision of the pseudoaneurysm was curative. The location of the splenic artery makes it especially vulnerable to aneurysmal formation in patients with pancreatitis. It is recommended that early arteriography be obtained in patients with obscure upper gastrointestinal bleeding. If the splenic artery aneurysm is located in the mid-portion of the vessel, partial pancreatectomy and splenectomy are not necessary to effect a cure.

Aneurysm↗
PubMedDate not supplied

Unusual presentation of ruptured splenic artery aneurysms.

Two cases of ruptured splenic artery aneurysms with unusual clinical presentation are reported. In one case an inflammatory abdominal process was suspected, while in the other the operation was delayed by several hours due to the unexplained coma, high blood sugar levels and lack of signs of shock until an advanced stage of the disease. As there was no active bleeding during the operation, the presence of free blood in the abdomen and clots in the omentum provided the clue for localization of the source of the bleeding.

Abdomen, Acute↗
PubMed1978

Hemosuccus pancreaticus (hemoductal pancreatitis): gastrointestinal hemorrhage due to rupture of a splenic artery aneurysm into the pancreatic duct.

A patient with recurrent upper gastrointestinal bleeding was found to have pancreatitis and a pseudoaneurysm of the splenic artery that communicated with the pancreatic duct. Similar pathology noted in ten other patients found in an extensive review of the literature suggest that this rare entity must be considered in the diagnosis of gastrointestinal hemorrhage of obscure origin. In this collected experience, the combination of recurrent left upper quadrant pain, a history of pancreatitis, and recurrent bouts of gastrointestinal bleeding of obscure origin were usually present in those patients who were found to have a splenic artery aneurysm as the source of the blood loss. Distal pancreatectomy with resection of the splenic artery aneurysm is curative.

Acute Disease↗
PubMed1978

Occurrence of large proximal splenic artery aneurysms in chronic liver disease.

Two cases are reported of large pre-splenic aneurysms of the splenic artery in patients with chronic liver disease, and three others cited from the literature. Four of the five died from rupture of the aneurysm. All patients were parous females with chronic liver disease, and in four of the five this was known to be present before pregnancy. It is suggested that proximal splenic artery aneurysms in such patients are due to both haemodynamic changes of portal hypertension and the endocrine changes of pregnancy. This concept may lead to early recognition of these lesions, although there are as yet no certain indications for investigation or surgical intervention in asymptomatic patients.

Adult↗
PubMed1979

The ligation of the splenic artery in the treatment of traumatic rupture of the spleen.

Overwhelming sepsis is splenectomized children may be a real threat to life. As an alternative to splenectomy, ligation of the splenic artery in combination which splenorrhaphy was used successfully in two children with splenic trauma involving major segmental vessels. In both patients the postoperative course was normal. Peripheral blood tests, immunological studies, and scintigraphies disclosed no abnormalities of the spleen after the ligation of the splenic artery. Aortographies showed a collateral arterial network in the spleen. Therewith, 11 and 12 months after the operation, respectively, both cases--the first of our series--are presented and discussed.

Child, Preschool↗
PubMedDate not supplied

Aneurysm of the splenic artery.

Two cases of multiple aneurysms of the splenic artery are reported. The aneurysms themselves were asymptomatic and the patients were operated upon for other reasons. In the first case the aneurysm was of an arteriosclerotic nature and in the second it coexisted with portal hypertension. The literature on this subject is briefly reviewed.

Aneurysm↗
PubMed1975

[Catheter embolisation of the splenic artery as treatment for acute bleeding from varices (author's transl)].

Embolisation of the splenic artery with fibrin foam, in order to stop acute bleeding from varices, was carried out in two patients. This was performed immediately after diagnostic arterial indirect demonstration of the portal vein; by this method it is possible to achieve at least a temporary cessation of bleeding from oesophageal or gastric varices. The procedure is indicated in desparate situations, if intubation has been unsuccessful or has had to be discontinued, when endoscopic sclerosis is contra-indicated or when an emergency shunt cannot be carried out because of poor liver function or the general condition of the patient. Permanent results cannot be expected and recurrence of bleeding cannot be avoided. The use of splenic embolisation depends on stopping the acute bleeding in order to obtain an interval during which liver function can be improved so that a decompressing shunt operation becomes possible subsequently.

Acute Disease↗
PubMed1979

Treatment of refractory splenomegaly in myeloproliferative disease by splenic artery infusion.

Five patients in the blastic phase of chronic granulocytic leukemia with massive splenomegaly were treated by intraarterial splenic artery infusion of cytosine arabinoside. All patients had massive splenomegaly associated with pain and/or hypersplenism and were refractory to previous therapy. All 5 patients demonstrated responses to treatment, with reduction in spleen size as well as symptomatic relief. Systemic toxicity was minimal in 4 of the 5 patients.

Adolescent↗
PubMed1976

Treatment of hypersplenism by embolus placement in the splenic artery.

In a patient with liver cirrhosis and severe hypersplenism resistent to corticosteroids splenectomy was attempted but proved impossible. Embolisation of the splenic artery with tiny fragments of absorbable gelatin sponge induced gradual restitution of haematological function to normal after 6 wk. Abdominal pain, paralytic ileus of short duration, transient pyrexia, and pleural effusion ensued but were well tolerated. The patient has remained well, 2 1/2 mo later. It is suggested that this simple method may prove rewarding and could safely be used, if necessary, more than once in patients for whom other treatments are unsuitable or have failed.

Angiography↗
PubMed1976

A morphologically different type of smooth muscle cell in the inner media of the splenic artery.

A morphologically different cell type to the typically smooth muscle cell has been found in the inner medial layers of the splenic artery. Besides the morphological differences, typical criteria for a smooth muscle cell are demonstrated, giving an account of their identity. Morphological details are described. The importance of these cells as regards lesions of the vessel wall is briefly discussed.

Adolescent↗
PubMed1979

Effect of furosemide on canine splenic arterial blood flow.

Furosemide has been reported to cause pathological changes in the intestines as a consequence of the decrease in splanchnic blood flow that it produces. In view of the pancreatic toxicities of this diuretic, it was of interest to examine the effect of the agent on blood flow to this organ. An electromagnetic flow probe, was placed around the splenic artery, a vessel which supplies a major fraction of pancreatic blood flow. Within 60 min after furosemide (1 mg/kg, iv) administration, splenic blood flow (SBF) decreased by 20% and the decrease paralleled the drug-induced diuresis. When the diuresis was prevented, the agent failed to affect SBF. Thus, furosemide causes a reduction in SBF, which appears to involve a mechanism dependent upon the volume reduction produced by the drug-induced diuresis.

Animals↗
PubMedDate not supplied

[Rupture of an aneurysm of the splenic artery into the pancreas, a rare cause of gastrointestinal bleeding (author's transl)].

In a 73 year old man, repeated gastrointestinal haemorrhages first attributed to peptic oesophagitis, recurred despite anti-reflux surgery. Upper endoscopy being negative, arteriography was performed which revealed the presence of a fissured aneurysm of the splenic artery. This was successfully treated by left splenopancreatectomy. A communication between the aneurysm and wirsung's duct was found in the operative specimen. This a very rare cause of gastrointestinal bleeding. The diagnosis can be made only by arteriography.

Aged↗