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At least 19 recordsLinked to original sources
PubMed1978

[A method for radio-immunological determination of g-strophanthin (author's transl)].

For the purpose of estimating g-strophanthin radio-immunologically the following steps are described: the preparation of g-strophanthin antigen, the production of antibodies in the rabbit, the presentation of calibration curves, and the possibility of a quantitative determination of heterogenous glycosides. According to Malaprades reaction, g-strophanthin adheres to human albumin. With this antigen thus obtained antibodies are produced in rabbits. For the presentation of calibration curves, the addition of antiserum and g-strophanthin have to be matched in quantity; the calibration curves correspond to mathematical data. An increased sensitivity of the method is possible to attain by reducing the amount of labelled antigen and antiserum. The slight cross-reactivity of antibodies can be used to determine other glycosides when these are incubated labelled with tritium instead of 3H-g-strophanthin.

Animals↗
PubMed1975

[Experimental heart muscle necorses in the rat after administration of 1-noreadrenaline and strophanthin. Light- and electron microscopic studies (author's transl)].

Female rats with a body weight of approximately 200 g regular show necroses of myocardial fibers after subcutaneous injection of 1-Noradrenaline (2.5 mg/kg body weight). After intraperitoneal premedication with Strophanthin k in a therapeutical dosage (2 X 10(-5 g/kg body weight), the increase in number and extent of the necroses is statistically significant. These findings argue against a preventive effect of Strophanthin k and can be explained by the mode of action of catecholamines and glycosides, as both substances, in a like manner, cause an increase in the mobilizable intracellular calcium of the myocardial fiber. Premedication with Strophanthin causes no alteration in the distribution pattern of necroses, nor in the electron-microscope findings in the case of myocardial necroses produced by Noradrenaline.

Animals↗
PubMedDate not supplied

[Strophanthin sensitivity in disorders of cardiac blood supply, altered immunologic reactivity and under the influence of several pharmacologic agents].

Tests conducted with 125 cats demonstrated that occlusion of the coronary artery causes a higher sensitivity to the bathmotropic action of strophanthin, but does not have any effect on the magnitude of its lethal dose. The efficaciousness of potassium orotate and also of Na2EDTA in combinations with anapriline and isadrine, as regulators of the sensitivity to the toxic effect of strophanthin, was investigated. Immunization of cats with a homocardiac antigen was found to produce biphasic changes in the sensitivity to the toxic effect of strophanthin associated with the duration of antigenic stimulation.

Animals↗
PubMed1979

[Absorption and excretion of g-strophanthin after intravenous or sublingual administration (author's transl)].

Tritiated g-strophanthin was administered to six volunteer patients in a dose of 0.25 mg intravenously and 6.0 mg sublingually 1-3 weeks apart. Radioactivity in plasma and urine was measured afterwards for 48 or 96 hours, respectively. Plasma concentration fell to about a fifth of the maximal concentration within 6 min after intravenous administration, total excretion within three days being about 50%, with a half-time of 11 hours. Measurable plasma concentration after sublingual administration was demonstrable only after 15 min in some and after 2 hours in all the six patients. Radioactivity counts increased up to the 24th hour, in three patients up to the 48th hour. Maximal plasma concentration ranged from 4.7 to 0.7 ng/ml, corresponding to levels reached 15 min or 4 hours, respectively, after intravenous administration. Urinary radioactivity reached its maximum after 24-48 hours and then decreased. Within three days 0.6 and 2.5% of the administered radioactivity was recovered, corresponding to the g-strophanthin doses of 0.072 to 0.3 mg. The findings once again confirm the low and irregular absorption of g-strophanthin when administered sublingually or orally.

Administration, Oral↗
PubMed1978

Actions of G-strophanthin, adrenaline and acetylcholine on bullfrog ventricular muscle in the sodium-free lithium solution.

The actions of g-strophanthin, adrenaline and acetylcholine on the action potential of bullfrog ventricular muscle were studied in the Na+ -free Li+ solution, in order to examine if these actions are associated with the change of active Na+ transport. The action of g-strophanthin on the action potential, being observed in the Ringer solution, completely disappeared in the Na+-free Li+ solution. On the other hand, the actions of adrenaline and acetylcholine remained unchanged in the Na+ -free Li+ solution, except the hyperpolarizing action of adrenaline on the resting membrane. These results suggest that changes of the action potential by g-strophanthin are secondary events caused by the change of active Na+ transport, whereas those by adrenaline and acetylcholine are primary events due to the change of membrane permeability.

Acetylcholine↗
PubMed1976

[Experimentally induced heart muscle fiber necroses after premedication with strophanthin (author's transl)].

Number and degree of angiotensin-induced heart muscle necrosis in the rat (75 mg/kg body weight) are diminuished by premedication with strophanthin (2 X 10(-2) MG/KG BODY WEIGHT). The electron-microscopic findings are also changed: the application of angiotensin only results in vacuolization of mitochondria and a dilatation of theendoplasmatic reticulum while myofibrils are unaltered. Angiotensin in combination with strophanthin has a direct destructive effect on the myofibrils without evident changes of the mitochondria and tubular system of the heart. The protective action of Strophanithin on the heart muscle cell is discussed in the sense of an exonomization of the cellular metabolism under conditions of relative coronary insufficiency, induced by the vasoconstructive effect of angiotensin.

Angiotensin II↗
PubMed1977

Toxicological evaluation of imipramine in combination with adriamycin and strophanthin.

Chronic oral administration of imipramine to rats caused characteristic changes of the electrocardiogram (ECG), i.e. prolongation of the PR interval, widening of the QRS complex, and increase in T-wave voltage. The cardiotoxic anthracycline antibiotic adriamycin induced dose-dependent widening of the QRS complex. This effect on intraventricular conduction was not enhanced in rats receiving both drugs. The high adriamycin dose (5 x 4 mg/kg) abolished imipramine-induced prolongation of the PR interval and T-wave elevation. This was not seen with the low adriamycin dose (20 x 1 mg/kg). Imipramine prolonged survival time of rats treated with toxic doses of adriamycin, but enhanced growth retardation in animals receiving the low adriamycin dose. Chronic treatment with increasing doses of strophanthin induced significant flattening of the T wave in rats with and without imipramine therapy, but did not influence the changes of the ECG or body weight gain caused by imipramine. It is concluded that the combined use of imipramine and adriamycin or strophanthin did not lead to a serious enhancement of the toxicity of the tricyclic antidepressant.

Animals↗
PubMed1978

[Combined use of glucagon and strophanthin in myocardial infarct complicated by severe cardiac insufficiency].

The effects of isolated and combined use of strophanthin and glucagon on the values of central hemodynamics and cardiac contractile function were compared. The study was conducted on patients with myocardial infarction complicated by congestive heart failure in the acute period of the disease. It was found that a combination of these drugs had a synergic inotropic effect. A conclusion was drawn on the advantages of the combined use of strophanthin and glucagon in the treatment of severe congestive heart failure in the acute period of myocardial infarction.

Acute Disease↗
PubMed1978

[Effect of strophanthin and atropine on atrioventricular conduction in acute myocardial infarct].

The effect of single therapeutic doses of strophanthin (0.25--0.4 mg) and atropine (0.75--1,0 mg) on cardiac contraction was studied in 39 patients with acute myocardial infarction and in 12 subjects with no signs of organic heart affection by recording the electrical potentials of the heart conduction system. The indicated dose of strophanthin caused changes in the intervals of the electrogram neither in individuals who did not have myocardial infarction nor in patients with acute myocardial infarction, including those with myocardial infarction complicated by atrioventricular and intraventricular block. Atropine improved atrioventricular conduction by shortening the PH interval in patients with myocardial infarction complicated by I--II grade atrioventricular block and had no marked effect on the spread of excitation impulses along the atrioventricular node in higher grades of atrioventricular block. Atropin shortened the PH interval slightly in individuals without myocardial infarction and in patients with uncomplicated myocardial infarction, but did not have an effect on intraventricular conduction.

Acute Disease↗
PubMedDate not supplied

[K-strophanthin-beta complexing with calcium, magnesium and dysprosium ions].

Nuclear magnetic resonance, microcalorimetry and the use of the ion-selecting electrode evidenced that k-strophanthine-beta forms complexes with the calcium, magnesium and disprosium ions. Changes in the position of the k-strophanthine-beta carbohydrate parts and aglycones signals bear witness to their participation in the complexing.

Calcium↗
PubMed1978

[Dynamics of the amount of fluid in the chest cavity and lower extremities in cardiac insufficiency under the influence of strophanthin and lasix].

The effect of lasix (in 51 patients) and strophanthin (in 16 patients) on the dynamics of changes in the amount of fluid in the chest and leg in cardiac insufficiency was studied by impedance plethysmography. It was established that in isolated insufficiency of only the left parts of the heart, parenteral administration of 20 mg of lasix led almost in all cases to a decrease in the total amount of fluid in the chest and its organs by 14% on the average; the decrease in the volume of fluid in pulmonary edema, cardiac asthma, and insufficiency of the left parts of the heart without acute manifestations is practically the same and amounts to 17, 14, and 12% on the average, respectively. In isolated hypervolemia of the pulmonary circulation, lasix causes a decrease in the amount of fluid in the leg also, by 7% on the average, in three fourths of cases. In total cardiac insufficiency, lasix reduces the volume of fluid in the chest and leg to a similar degree (by 13 and 16% on the average) practically in all cases.

Clinical Trials as Topic↗
PubMed1979

[Vegetative parameters under the effect of ouabain (g-strophanthin) in endogenous depressive patients. 1. The salivation rate].

In 7 healthy test persons and in 17 endogenous depressive patients the salivations rate was measured in a survey investigation with the SHP-test. The salivation rate of healthy test persons is constant. In endogenous depressive patients it develops a diminishing of depression depth under treatment with Ouabain (g-Strophanthin) between the 6th and the 12th day which is connected with reduction of the drive diminishing and the restauration of mood. The effective salivation rate is gaining. Possible principles of the influence of Ouabain are discussed.

Depression↗