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Results for “Synovitis, Pigmented Villonodular”

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At least 19 recordsLinked to original sources

PubMed1990

Pigmented villonodular synovitis.

Pigmented villonodular synovitis is a benign disease of the synovial membrane of joints, tendon sheaths, or bursae, which nevertheless can cause marked local destruction. Its diagnosis is often delayed because complaints and symptoms are nonspecific. Familiarity with the disease may ensure an earlier diagnosis and consequently early onset of therapy, which may prevent serious damage. This paper describes 18 patients suffering from localized or diffuse pigmented villonodular synovitis. Findings possibly suggestive of pigmented villonodular synovitis include hemarthrosis, soft tissue swelling, radiological evidence of cyst formation at a distance from the weight-bearing area of a joint, an increased triglyceride concentration, and a positive bone scan. A normal appearance on arthroscopy does not rule out the disease. Therapeutic results are better in the localized than in the diffuse form of the disease.

Adolescent↗

PubMed1991

Cytogenetic evidence of clonality in a case of pigmented villonodular synovitis.

Pigmented villonodular synovitis is an uncommon benign lesion that is characterized by diffuse synovial proliferation. Based on animal models, this lesion has been conjectured previously to be reactive in nature. In this report, the authors present the histologic and cytogenetic findings for a pigmented villonodular synovitis that was excised from the right knee of a 47-year-old man. Trisomy 7 was observed in 24 of 75 (35%) metaphases obtained from short-term culture of cells from this tumor. These findings suggest that some cases of pigmented villonodular synovitis represent clonal, neoplastic proliferations.

Chromosomes, Human, Pair 7↗

PubMed1993

[Imaging of pigmented villonodular synovitis].

Pigmented villonodular synovitis is a rare disease which is usually benign but sometimes causes wide articular destruction. Since its clinical signs and symptoms are not specific, the disease may remain undiagnosed, sometimes for long periods. The diagnosis is generally confirmed at pathology, but it can now be strongly suggested by modern imaging methods. Standard radiography may be normal, with a variety of images. Arthrography with an opaque material points to the diagnosis in only two-third of the cases. Ultrasonography is non-specific. Computed tomography may be strongly suggestive of pigmented villonodular synovitis in cases with high density synovia; when coupled with arthrography, it provides detailed information on lesions of the cartilage and on extension of the synovial process. The most sensitive and specific method is magnetic resonance imaging, the most characteristic sign being low-intensity signal areas on T1- and T2-weighted sequences, corresponding to haemosiderin-loaded nodules. Performed after standard radiography, magnetic resonance imaging is the best examination method for the diagnosis and pretherapeutic evaluation of suspected villonodular synovitis.

Humans↗

PubMed2006

Pigmented villonodular synovitis.

Pigmented villonodular synovitis is a proliferative condition of the synovium. Monoarticular involvement, the most common process, occurs in two forms: localized and diffuse. The localized form is characterized by focal involvement of the synovium, with either nodular or pedunculated masses; the diffuse form affects virtually the entire synovium. The localized form has an excellent prognosis and a low recurrence rate when managed surgically. The more common diffuse form has a reported recurrence rate of up to 46%. Although the condition can present in any joint, the knee is the most commonly affected site. Pigmented villonodular synovitis is often aggressive, with marked extra-articular extension. Open synovectomy is the standard method of management. Arthroscopic synovectomy, which has gained popularity, has several advantages over the open technique, but it is associated with higher recurrence rates in diffuse pigmented villonodular synovitis. Synovectomy by any approach, however, may prevent secondary osteoarthritis and subsequent joint arthroplasty. Radiation-induced synovectomy has shown mixed results. Combined surgical and nonsurgical approaches may be necessary, and in some patients, total joint arthroplasty may be the only effective treatment.

Humans↗

PubMed1986

[Combined treatment of the diffuse form of pigmented villonodular synovitis].

Pigmented villonodular synovitis is a specific lesion of the synovial membrane of the joint and bursal mucosa. In recent years it is frequently regarded as tumor like disease. The problem of therapy of the diffuse form of the disease is yet to be solved. Recurrence rates after partial synovial capsulectomy remain high (33-46%) as well as after operation combined with radiation therapy. The authors summed up their experience in combined therapy of pigmented villonodular synovitis. The method was used in 24 patients with the diffuse form of the disease, ranging in age from 15 to 62. In 18 of 24 patients the process affected the knee joint, in 6 patients the articular bones were involved in the process. Partial synovial capsulectomy with subsequent development of recurrences was recorded in 14 patients' history. Total synovial capsulectomy was performed at the first stage; in knee joint involvement the operation was supplemented by meniscectomy. gamma-beam therapy followed operation in 3-4 weeks. Radiotherapy was necessitated by the fact that elements of the affected synovial sheath could not be completely removed even in total synovial capsulectomy. Irradiation was given from 2 fields, a single focal dose being 1.2-1.5 Gy, 5 fractions a week; a summary focal dose reached 16-20 Gy. A follow up period lasted from 6 mos to 6 yrs. Complete convalescence was noted in 23 patients. Occupational rehabilitation was achieved in 21 patients. In 2 patients the functional outcome was considered to be satisfactory. The data obtained indicated to a high efficacy of combined therapy of the diffuse form of pigmented villonodular synovitis and the appropriateness of the use of radiotherapy in the postoperative period.

Adolescent↗

PubMedDate not supplied

Pigmented villonodular synovitis.

Pigmented villonodular synovitis, a rare tumor of the synovial lining of a joint, is suggested when aspiration of a chronically swollen and painful single joint (usually the knee) yields a brownish fluid. The diagnosis is confirmed by biopsy, and the preferred treatment is complete excision of all involved synovial tissue. The recurrence rate is directly related to the degree of synovial involvement and to the thoroughness of the synovectomy performed. Although pigmented villonodular synovitis does not become malignant, it can destroy a joint so that an arthroplastic procedure may be necessary.

Arthroscopy↗

PubMed1994

Expression of metalloproteinases in pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVNS) is an idiopathic proliferative synovial process composed of two predominant cell types: mononuclear histiocytic cells and giant cells. This lesion can be locally invasive and can result in bone cyst formation and late cartilage and bone loss. Because metalloproteinases have been implicated in the joint destruction occurring in inflammatory arthritis and in the ability of certain tumors to invade adjacent tissues, their presence in PVNS was determined. Synovial tissue samples were collected at surgical synovectomy from the knees of 10 patients with a prior histological diagnosis of PVNS. Pigmented villonodular synovitis synovium was examined for the presence of the metalloproteinases collagenase and stromelysin. Messenger RNA (mRNA) for collagenase and stromelysin was present in all patient samples, although in varying amounts. In situ hybridization studies on synovial tissue sections identified synovial lining cells as the predominant cells expressing these metalloproteinases. Occasional infiltrating mononuclear histiocytic cells also were producing metalloproteinase mRNA. Giant cells did not express mRNA for the metalloproteinases collagenase and stromelysin. These results suggest that collagenase and stromelysin may be among the mediators of cartilage and bone loss that can occur in PVNS.

Adult↗

PubMed1991

Pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVS) is an uncommon, usually monoarticular disorder encountered mainly in adults. A boy and a girl, both 7 years old, were referred because of recurrent knee effusions. Both were medically treated for other rheumatic disorders for five years. PVS was diagnosed by arthroscopy and synovectomy was curative in both cases.

Arthroscopy↗

PubMed1991

[Magnetic resonance imaging of the knee. 3 cases of pigmented villonodular synovitis].

Pigmented villonodular synovitis is a benign monoarticular synovial proliferative disorder. Three cases involving the knee are reported. MR signs are highly suggestive: --joint effusion (blood); --hypointense synovial proliferation (irregular infrapatellar fat pad sign; hemosiderin deposits); --no loss of joint space. Diagnosis by MR Imaging is early, accurate and atraumatic.

Adult↗

PubMed2004

Pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVNS) is a rare benign proliferative growth of the synovium of obscure aetiology with a wide spectrum of clinical presentations and imaging findings. The purpose of this review is to acquaint the reader with the spectrum of imaging features of PVNS using a variety of imaging techniques.

Adult↗

PubMed1996

Pigmented villonodular synovitis.

Pigmented villonodular synovitis is a benign proliferative disorder of the synovium of uncertain cause. It may involve tendon sheaths, bursae, or joints, the latter occurring as diffuse involvement or a localized nodule. This article reviews the clinical features of the disorder and the imaging features of the disease, concentrating on the findings and utility of MR imaging.

Arthrography↗

PubMed1983

[Pigmented villonodular synovitis].

Pigmented villonodular synovitis (PVNS) is a comparatively rare disease of which some 2000 case reports are found in the international literature. PVNS should nevertheless be considered in the differential diagnosis of mono- and oligoarthritis. Three further cases of PVNS are presented in which the diagnosis was confirmed histologically. The clinical, X-ray, laboratory and histologic findings in PVNS, and the differential diagnosis and aetiology are discussed.

Adult↗

PubMed2006

Pigmented villonodular synovitis.

Pigmented villonodular synovitis is a benign proliferative lesion of the synovium with unclear etiology. It is a locally aggressive lesion that may invade and destroy surrounding bone and soft tissues and represents a high rate of recurrence despite aggressive treatment modalities. This article describes the new developments in etiology and outlines current approaches for diagnosis and treatment.

Adult↗

PubMed2006

[Pigmented villonodular synovitis].

Pigmented villonodular synovitis (PVNS) is a rare, strongly proliferative disease of the lining of thejoint, synovial bursa and tendon (synovial) sheath. If left untreated, it leads to severe destruction of the joint resulting in an early need for endoprosthetic replacement. The clinical signs are unspecific. Using the diagnostic gold standard MRI, the complete extent of PVNS can usually be determined non-invasively. Once histological confirmation has been obtained, radical tumor resection, synovectomy, possibly curettage, and postoperative irradiation must be applied.

Arthroplasty, Replacement, Knee↗

PubMed2004

The rusty knee--pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVNS) is a distinct but rare clinical entity often presents late with a diagnostic difficulty. Its non-specific manifestations require exclusion of several chronic inflammatory disorders and other humorous lesions but all investigations including highly predictive magnetic resonance imaging (MRI) and arthroscopic examination are non-diagnostic demanding confirmatory tissue biopsy. A typical case of such lesion is presented to highlight some potential difficulties.

Adult↗

PubMed1992

Immunohistochemical characterization of pigmented villonodular synovitis.

Pigmented villonodular synovitis is made up of a variety of cells, including round or oval mononuclear cells, fibroblasts, synovial cells and multinucleated giant cells. The mononuclear cells were found to stain positively with anti-lysozyme, anti-alpha-1-antitrypsin, anti-alpha-1-antichymotrypsin and anti-fibronectin. Vimentin was detected in fibroblasts and in lining cells of the synovial membrane as well as in cells of acinus-like structures. The multinuclear giant cells contained lysozyme, alpha-1-antitrypsin and alpha-1-antichymotrypsin but no vimentin.

Adult↗

PubMed2001

Radiologic case study. Pigmented villonodular synovitis.

Pigmented villonodular synovitis is a benign, locally aggressive disorder characterized by a unique clinical radiographic, and histopathologic presentation. While it is considered to be a rare disorder, a delay in diagnosis and treatment can potentially result in severe disruption of joint function due to subchondral invasion. Once the diagnosis is confirmed, treatment should consist of complete synovectomy. Recurrence is common, but malignant transformation is rare. The etiology of PVNS is still unknown, and perhaps its future discovery will assist in the definitive treatment of this disorder.

Adult↗

PubMed2003

Imaging of pigmented villonodular synovitis.

Pigmented villonodular synovitis (PVNS) is a rare, benign, idiopathic proliferative disorder of the synovium that results in villous and/or nodular formation in joints, tendon sheaths, and bursae. The disease can be localized or diffuse. Patients with this condition typically present with symptoms of mild discomfort and associated stiffness of the involved joint; however, the spectrum of presentations is broad. Diagnosis of PVNS can be clinically difficult, and plain radiographs are usually nonspecific. Magnetic resonance (MR) imaging is a highly diagnostic modality in characterizing PVNS when it contains hemosiderin deposits exhibiting low signal intensity on all MR image pulse sequences. This article discusses the presentation, pathology, differential diagnosis, diagnostic modalities as well as various treatment options of PVNS.

Arthrography↗