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At least 19 recordsLinked to original sources

PubMed2005

Tarsus determination in Drosophila melanogaster.

Arista versus tarsus determination is well investigated in Drosophila, yet it remains unresolved whether Antennapedia (ANTP) cell autonomously or noncell autonomously determines tarsus identity and whether Sex combs reduced (SCR) is the HOX protein required for normal tarsus determination. Three observations rule out a cell autonomous role for ANTP in tarsus determination. (i) Clonal ectopic overexpression of ANTP did not repress the expression of the arista determining protein Homothorax (HTH) in early 3rd stadium antennal imaginal discs. (ii) Clonal ectopic expression of ANTP did not transform the arista to a tarsus. (iii) Ectopic overexpression of ANTP, Labial (LAB), Deformed (DFD), SCR, Ultrabithorax (UBX), Abdominal-A (ABD-A), or Abdominal-B (ABD-B), using the dppGAL4 driver, resulted in arista-to-tarsus transformations, and repressed HTH/Extradenticle (EXD) activity noncell autonomously in early 3rd stadium antennal imaginal discs. SCR may not be the HOX protein required for normal tarsus determination, because co-ectopic expression of Proboscipedia (PB) inhibited the arista-to-tarsus transformations induced by ectopic expression of DFD, SCR, ANTP, UBX, ABD-A, and ABD-B. The proposal that SCR is the HOX protein required for normal tarsus determination is dependent on SCR being the sole target of PB suppression, which is not the case. Therefore, the possibility exists that normal tarsus determination is HOX independent.

Animals↗

PubMed1998

Analysis in Drosophila melanogaster of the interaction between sex combs reduced and extradenticle activity in the determination of tarsus and arista identity.

Sex Combs Reduced (SCR) activity is proposed to be required cell nonautonomously for determination of tarsus identity, and Extradenticle (EXD) activity is required cell autonomously for determination of arista identity. Using the ability of Proboscipedia to inhibit the SCR activity required for determination of tarsus identity, we found that loss-of-EXD activity is epistatic to loss-of-SCR activity in tarsus vs. arista determination. This suggests that in the sequence leading to arista determination SCR activity is OFF while EXD activity is ON, and in the sequence leading to tarsus determination SCR activity is ON, which turns EXD activity OFF. Immunolocalization of EXD in early third-instar larval imaginal discs reveals that EXD is localized in the nuclei of antennal imaginal disc cells and localized in the cytoplasm of distal imaginal leg disc cells. We propose that EXD localized to the nucleus suppresses tarsus determination and activates arista determination. We further propose that in the mesodermal adepithelial cells of the leg imaginal discs, SCR is required for the synthesis of a tarsus-inducer that when secreted acts on the ectoderm cells inhibiting nuclear accumulation of EXD, such that tarsus determination is no longer suppressed and arista determination is no longer activated.

Animals↗

PubMed1998

Effectiveness of homologous cadaveric fascia lata and role of suture fixation to tarsus in frontalis suspension.

The results of frontalis suspension (double rhomboid technique with preserved homologous cadaver fascia) were compared in two surgical groups: 1) patients in whom the fascia was sutured to the tarsus and 2) patients in whom the fascia was not sutured to the tarsus. The study was performed to determine the optimum surgical technique and to determine whether preserved cadaver fascia is a suitable suspensory material. All data retrospectively reviewed included 1) predisposing cause of severe blepharoptosis, 2) results in the two groups of patients, suture fixation and nonsuture fixation, and 3) surgical complications. Of the 27 patients (36 eyelids), the fascia was sutured to the tarsus in 15 patients (20 eyelids) and not sutured to the tarsus in 12 patients (16 eyelids). In the suture fixation group, no undercorrections occurred, but four of 20 eyelids had lower than expected eyelid creases and six had residual dermatochalasis. Six patients had lagophthalmos with corneal exposure that required intense corneal lubrication, and three such patients required temporary tarsorrhaphy for 3 weeks. In the group without suture fixation, two patients had undercorrection (one with ocular cicatricial pemphigoid and the other with myotonic dystrophy). The mean followup period was 44 months. We conclude that preserved fascia provides excellent results with or without fixation of the fascia to the tarsus. In patients with suture fixation, the eyelid crease may form just above the point at which the fascia is sutured to tarsus and result in a low eyelid crease. Excision of excess skin should be considered at the time of frontalis suspension in selected patients in whom the fascia is fixated to the tarsus or who have preexisting dermatochalasis. Patients with suture fixation may have significant temporary postoperative lagophthalmos.

Adult↗

PubMed2001

[Morphometric features of tarsus in Dermacentor reticulatus (Fabricius, 1794) (Acari: Ixodida: Ixodidae) larvae from Polish and Slovakian populations].

Dermacentor reticulatus is widely distributed dangerous tick that usually lives in the river valleys, boggy forests, meadows, and wooded pastures. Tick populations from various regions may exhibit morphological differences. In our study we compared morphometric features of tarsus in larvae D. reticulatus from Polish and Slovakian populations. I tarsus width, III tarsus length, and length of dorsal setae of I tarsus were significantly higher in Polish populations. Indices of width to length of tarsus I and tarsus III were also significantly different in both populations. The other examined morphologic features were similar, what may result from the same environmental conditions of both populations.

Animals↗

PubMed1995

[Chondroplast as tarsus substitute in eyelid reconstruction].

After tumor excision both lamallae of the eyelid have to be recreated to achieve good functional and cosmetic results. Tarsus should be replaced either by autologous cartilage like nasoseptal/ear cartilage, autologous lid cartilage or heterologous materials like a polytetrafluorethylene soft tissue patch (Goretex). We used Chondroplast as tarsus replacement in five patients after extensive tumor excision. Chondroplast is beta-irridiated, bovine cartilage. A thin 1.0-mm-thick lamella is fixed to the rest of the tarsus plate or the canthal tendon and positioned in a preformed pocket of conjunctiva and a thin layer of orbicularis muscle and skin. It is most important to cover the new tarsus completely with orbicularis muscle and conjunctiva. All implants took well. The postoperative results, lid closure and cosmetic appearance are excellent. No complications like infection or loss of the transplant occurred. The Chondroplast advantages are: availability in big pieces, no need for harvesting procedures and good biocompatibility. For these reasons Chondroplast proved to be an excellent graft to rebuild the tarsus and provides stability of the eyelid.

Aged↗

PubMed1980

Height of the tarsus of the lower eyelid.

The vertical height of the lower eyelid tarsus of 20 patients submitting to lower eyelid resections and the lower tarsus of 17 cadavers was 3.7 mm (+/- 0.3) and 3.9 mm (+/- 0.5), respectively. The average value found in our patients was statistically different (P less than .05) than the values of 5 to 7 mm reported previously. The lower tarsus should be clearly identified in procedures involving eyelid repair or eyelid reconstruction so that tension-bearing sutures can be placed through the tarsus.

Adult↗

PubMed1975

The diagnosis of chronic simple conjunctivitis. Vital staining of tarsus with tetrazolium - alcian blue mixture.

Vital staining with a tetrazolium - alcian blue mixture gave a characteristic punctate red staining of the superior or the inferior tarsus in 69% of all examined patients with chronic simple conjuctivitis (69 patients subjected to 168 examinations). The superior tarsus was more frequently stained than the inferior (61% against 33%). The staining was most often concentrated centrally or in the middle anterior part of the superior tarsus. If located on the inferior tarsus, it was most often found medially, anteriorly. No corresponding staining was seen in normal eyes. The differential diagnosis involving keratoconjunctivitis sicca and pemphigoid is mentioned. The staining is due to enzymatic reduction of tetrazolium in the cytoplasm of the tarsal epithelial cells. The positive vital staining finding is consistent with a diagnosis of chronic simple conjunctivitis.

Alcian Blue↗

PubMed1994

The anatomic features of the normal tarsus of the live horse as perceived by the sense of sight.

A description is given of 75 features present in the normal tarsus of the standing horse which are apparent due to visible skin contours overlying them. Depending on whether or not the pelvic limb is supporting full weight or resting, some contours alter their configuration. Therefore the contour of each underlying feature is described separately for each stance of the limb. It is considered that visual inspection and identification of the apparent superficial features of the normal equine tarsus form the basis of orientation and clinical inspection. Furthermore, these features provide reference points for procedures associated with surgery, arthroscopy, intraarticular treatment and anesthesia of a horse's tarsus suspected of being injured or infected.

Animals↗

PubMed2006

Correlation of magnetic resonance images with anatomic features of the equine tarsus.

OBJECTIVE: To correlate anatomic features of the equine tarsus identified in plastinated sections with images obtained via magnetic resonance imaging (MRI). ANIMALS: 4 horses. PROCEDURE: MRI (1.5-Tesla magnet) of the tarsus was performed on the pelvic limbs of 4 clinically normal horses following euthanasia. After imaging, tarsocrural joint spaces and vasculature were injected with colored latex. Sagittal and transverse sections of the tarsi were plastinated to facilitate interpretation of MR images. RESULTS: Relevant anatomic structures were identified and labeled on the plastinated tissue slices and corresponding MR images. Results indicated high correlations between MRI findings and those of plastinated sections. CONCLUSIONS AND CLINICAL RELEVANCE: The data obtained provided certain reference standards for normal anatomic structure sizes and positions in the equine tarsus. This information may aid future physiologic or clinical studies of this joint.

Animals↗

PubMed2005

Pathogenesis and surgical correction of dynamic lower scleral show as a sign of disinsertion of the levator aponeurosis from the tarsus.

The purpose of this study was to confirm whether lower scleral show is caused by the disinsertion of the levator aponeurosis from the tarsus. Aponeurotic advancement by vascular clips or by surgery involving the orbital septum significantly lowered the global position in the orbit and significantly diminished the degree of retraction of the lower eyelid, resulting in satisfactory improvement of lower scleral show in 100 patients with various aponeurotic blepharoptosis. Therefore, we propose the pathogenesis of lower scleral show as follows: additional contraction of the levator muscle to compensate for the disinsertion of the levator aponeurosis from the tarsus for maintenance of an adequate visual field is accompanied by additional contraction of the superior rectus muscle through the strong intermuscular fascia, resulting in upward rotation of the globe. To maintain the horizontal visual axis and foveation without inclination of the head in the primary gaze position, additional contraction of the inferior rectus muscle is induced, which pulls upon the inferior suspensory ligament of Lockwood and the capsulopalpebral fascia. The former displaces the globe upwards and the latter retracts the lower eyelid, resulting in dynamic lower scleral show as a sign of disinsertion of the levator aponeurosis from the tarsus, which can be surgically corrected.

Adolescent↗

PubMed1990

Taxeopody in the carpus and tarsus of Oligocene Pliohyracidae (Mammalia: Hyracoidea) and the phyletic position of hyraxes.

Recent hyracoids and elephants share a taxeopode arrangement of tarsal and carpal bones, a condition in which bones are aligned with minimal interlocking between adjacent elements. Taxeopody has often been interpreted as a synapomorphy reflecting a close phyletic link between Hyracoidea and Proboscidea, but recently it has been suggested [Fischer, M. S. (1986) Cour. Forschungsinst. Senckenberg 84, 1-132] that hyracoid taxeopody is an independent acquisition resulting from selection favoring increased midcarpal and midtarsal rotation and that Hyracoidea is actually allied with Perissodactyla. As a test of this hypothesis, isolated carpal and tarsal bones of primitive Oligocene hyracoids from the Fayum, Egypt, have been examined to determine whether these indicate a taxeopode or diplarthral carpus and tarsus. Four complete astragali from the Fayum, representing at least three taxa, show a single, slightly convex articular surface on the head for articulation with the navicular and lack a facet for the cuboid. Two complete magna representing two species have a single proximal facet for articulation with the lunar, and they lack a facet for the scaphoid. Thus, both the carpus and tarsus of Fayum hyracoids are taxeopode. Taxeopody in hyracoids cannot be attributed to selection for carpal and tarsal rotation in climbers because the Oligocene, Miocene, and Recent species show great diversity in body size and probably locomotor specializations, despite relative uniformity of structure in the carpus and tarsus. The shared taxeopody of hyracoids and proboscideans, along with other osteological characters and similarities in hemoglobin, eye lens proteins, and other molecules, all suggest that Hyracoidea belongs within Paenungulata.

Animals↗

PubMed2005

Free tarsus autogenous graft struts for lower eyelid elevation.

PURPOSE: Free tarsus autogenous graft (FTG) has emerged as a useful biological spacer in lower eyelid elevation. However, it has limited use where a spacer of greater than 4 mm height is required, because at least 4 mm of upper tarsal height must be preserved to maintain upper eyelid rigidity. We describe an augmentation of FTG in its use as a spacer, by way of creating 2 parallel-placed vertical FTG struts, in contrast to interpositioning the FTG horizontally. METHODS: This case series describes the technique of harvesting and interpositioning FTG struts. Nine eyelids in 6 patients in whom FTG struts were used for lower eyelid elevation are reported. The patients ranged in age from 41 to 80 years. Underlying diagnoses included thyroid orbitopathy, previous blepharoplasty, and previous facial and eyelid thermal burns. RESULTS: FTG struts achieved an effective spacer height of up to 7 mm, and follow-up of 9 to 20 months revealed a good outcome in all 3 cases, with no complications. CONCLUSIONS: FTG struts provide an effective and lasting lower eyelid elevation when used as a spacer. A spacer graft of up to 7 mm in vertical height may be harvested from a long strip of upper eyelid tarsus that is 4 mm in vertical height. This technique would allow autogenous upper eyelid tarsus to be harvested with maximum conservation of tissue.

Adult↗

PubMedDate not supplied

Computed tomographic anatomy of the equine tarsus.

The purpose of this study was to provide a detailed computed tomographic (CT) anatomic reference for the equine tarsus. CT examinations of the tarsal regions from four clinically and radiographically normal adult horses, which were euthanized for reasons not related to musculoskeletal disease, were included in the study. Limbs were removed at the level of midtibia, and 3-mm contiguous transverse CT images were obtained, starting at a level proximal to the tuber calcanei and continuing distally into the proximal metatarsus. Soft tissue and bone windows were used to image different anatomic features, including bones, joints, and various soft tissue components of the tarsus. Each transverse slice was compared with bone models and dissected specimens to assist in the accurate identification of specific structures. The results of the study consist of nine CT images of the equine tarsus. Each image incorporates labeled soft tissue and bone-window images, a directional compass indicating cranial (Cr) or dorsal (D) and lateral (L), and a reconstructed scout image indicating the level through which the transverse slice was made.

Animals↗

PubMed2001

Risk factors associated with hindlimb lameness and degenerative joint disease in the distal tarsus of Icelandic horses.

The aim of this study was to evaluate potential risk factors associated with hindlimb lameness and radiographic signs of degenerative joint disease (DJD) in the distal tarsus in Icelandic horses. The material consisted of riding horses (n = 420) age 6-12 years sired by 17 selected sires representing all major breeding lines, and of riding horses (n = 194) in the same age range sired by other sires. The examination protocol included the following: interview with owners/trainers, assessment of conformation, motion evaluation and radiographic examination. At the interview, data related to factors outside the horse (environmental variables) and data associated directly with the horse (intrinsic variables) were obtained. Data analysis was performed in 2 steps: screening using bivariate analysis, followed by testing with a multivariate logistic regression model. In the multivariate analysis, the factors of sire, age when broken to saddle and stud show participation were strongly associated with the prevalence of lameness. Height at the croup and ability to perform different gaits were also associated with the prevalence of lameness, but to a lesser degree. The risk factors of age, tarsal angle and birthplace were significantly associated with radiographic signs of DJD in the distal tarsus. Neither the variation in applied training intensity, the use of a professional or amateur trainer nor the temperament or front limb action of the individual horse was significantly associated with the prevalence of hindlimb lameness and/or radiographic signs of DJD in the distal tarsus in the Icelandic horse.

Age Factors↗

PubMed1985

The constraint-mechanism of the human tarsus. A roentgenological experimental study.

The main purpose of this investigation was to extend the work of Huson, Ambagtsheer and Van Langelaan to living subjects. It may thus be regarded as the logical continuation of Van Langelaan's study. The investigation consists of three main parts: In part 1 (Chapter 2), stepwise supination of the tarsus of fixed osteoligamentous preparations (the mode of supination studied by Van Langelaan) was compared with continuous supination. We found that stepwise supination of lower leg foot-preparations differs little from the continuous supination. The speed at which the continuous movement is carried out, and the amount of vertical loading, have only very slight effects. We could discern clearly that the visco-elastic properties of the tissues caused a difference in the paths of the supinating and pronating movements, the hysteresis effect. During this investigation we discovered by coincidence that the input moment to be applied to the tibia to supinate the tarsus by rotation varied greatly from one individual to another. The same was true for the vertical tibial translation during supination. This finding that differently shaped feet also differ in biomechanical behaviour prompted an extra line of investigation with which we attempted to quantify this biomechanical behaviour by measuring moments and recording vertical tibial translations, combining the two and relating them to a new roentgenological classification of the tarsus. The traditional specification criteria were found to be unsuitable. A strong correlation was found to exist between moment (M) and vertical tibial translation (S). Another strong correlation was observed between M and S and the tarsal index it, calculated with the equation (Formula: see text) The index is determined entirely by the relative positions of the talus and calcaneus. Part 2 (Chapter 3) comprises a study of fresh amputation material, as a step in the direction of live material. Two amputated lower legs were analyzed kinematically, according to Van Langelaan and Spoor's photogrammetric method; dynamically, by measuring moments (M) and recording vertical tibial translations (S); and finally by comparing the stepwise and continuous supination and pronation of one specimen (female 29). Each method was applied both to the completely intact specimen and to the dissected osteo-ligamentous preparations. As kinematic parameters we used the helical axes. We calculated both the relative axes (of the movements of one tarsal bone in relation to another) and the absolute discrete axes (of the tarsal bones in relation to the fixed reference system in the test setup) of supination from 0 degree -30 degrees and return.(ABSTRACT TRUNCATED AT 400 WORDS)

Adult↗

PubMed1975

Internal tarsus-orbicularis resection for senile spastic entropion.

This report describes the surgical correction of senile spastic entropion by internally resecting tarsus and orbicularis muscle. A triangle of tarsus is removed with the apex at the margin and the base at the inferior border and a similar amount of orbicularis muscle is resected. Each layer is approximated separately. The shortened tarsus improves the apposition of the lid aagainst the globe and the tightened orbicularis aids in maintaining this stability.

Aged↗

PubMed2001

[A clinical observation of preserved donor tarsal plate transplantation for repair of tarsus defect].

OBJECTIVE: To investigate the effect of preserved donor tarsal plate transplantation on the repair of the tarsus defect at the time of eye lid tumor removal. METHODS: Donor tarsal plates preserved in pure glycerin were used for the repair of tarsus defects of 58 cases after the complete removal of the eye lid tumors. The grafts were covered with rotated or slid myocutaneous and conjunctival flaps. The associations of the effect with the blood supply, with the size and the preserved time of the donor tarsal plates, as well as with the follow-up time were analyzed by chi(2) test. RESULTS: Of the 43 cases whose plates were fully covered with conjunctival flaps, new blood vessels began growing into the donor tarsal plates one week after the operation. The grafts were vascularized one month later. The donor tarsal plates of 15 cases were only partly covered with conjunctival flaps. As a result, the grafts were vascularized in 2 -- 3 months, and there was dissolution to varying degrees at the surface of the exposed parts of the plates. The effects of the 43 cases with good blood supply were significantly better than the effects of 15 cases with poor blood supply (chi(2) = 5.81, P < 0.05). The sizes of the donor tarsal plates ranged from 5 x 10 mm(2) to 8 x 29 mm(2). Eleven cases were equal or shorter than half of the original sizes of donor tarsal plates, 34 cases were subtotal and 13 cases were total plates. The differences of the sizes led to different results (chi(2) = 6.28, P < 0.05). The preserved times of donor tarsal plates were from 1 week to 2.5 years. However, the results were similar in all cases (chi(2) = 0.99, P > 0.05). All the patients were followed up for 6 months to 10 and half years (mean, 1.8 years). The effects had no statistical significance (chi(2) = 0.85, P > 0.05). The cilia of the donor tarsal plates were preserved in 3 cases, but all of them were totally lost during post-operative one month. After operation slight entropion occurred in 8 cases, slight ectropion in 3 cases, lagophthalmos for 2 -- 3 mm in 7 cases, notch of the palpebral margin in 5 cases and thinness of the donor tarsal plates in 4 cases, but the functional and aesthetic results were normal. Thirty-one cases were cured, 11 cases acquired tangible results and 12 cases were improved. The total effective rate was 93.1%. CONCLUSIONS: The more blood supplies of the donor tarsal plates, the better the effects. So we must make all our efforts to improve the blood supplies of the donor tarsal plates. The effects were associated with the sizes of the plates, but not associated with the preserved times of the grafts and the follow-up times. Preserved donor tarsal plate transplantation for the repair of tarsus defect is a relatively simple operation, the rejection is slight and the result satisfactory, thus it is an ideal plastic material.

Adult↗

PubMed1997

[Frozen-preserved tarsus of eyelid from new born in the repair of palpebral defect].

In order to repair palpebral defects resulted from various causes, frozen tarsus of eyelid from newborn was used. From Jan. 1993 to Feb. 1995, the frozen preserved tarsus of eyelid from new-born was used to repair the palpebral defect in 10 cases. These defects were resulted following operation in traumatic defect in 5 cases, tramatic defect in 3 cases and congenital defect in 2 cases. After 3 month to 3 years follow-up, no refection reaction was found and no complication was occurred. The external appearance following repair was good. The overall successful rate was 100%. It was suggested that the frozen preserved tarsus from new-born was a safe and reliable material in the repair of palpebral defects.

Adolescent↗