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At least 19 recordsLinked to original sources
PubMed1962

Autoradiographic study of DNA synthesis and the cell cycle in spermatogonia and spermatocytes of mouse testis using tritiated thymidine.

Mice were injected intraperitoneally with 15 microc of H(3)-thymidine. The time course of the labeling in spermatogonia and spermatocytes was studied by using autoradiography on 5 micro sections stained by the periodic acid-Schiff method and hematoxylin over a period of 57 hours after injection. Four generations of type A (called AI, AII, AIII, and AIV), one of intermediate, and one of type B spermatogonia occur in one cycle of the seminiferous epithelium. The average life span is about the same in all spermatogonia, i.e., about 27 to 30.5 hours. The average pre-DNA synthetic time, including the mitotic stages from metaphase through telophase and the portion of interphase preceding DNA synthesis, is also not very different, ranging between 7.5 and 10.5 hours. A remarkable difference exists, however, in the duration of DNA synthesis and of the post-DNA synthetic period. The average DNA synthetic time is very long and is highly variable in type B (14.5 hours), a little shorter and less variable in intermediate (12.5 hours) and AIV (13 hours) spermatogonia, and much shorter and very constant in AIII (8 hours), AII and AI (7 to 7.5 hours) spermatogonia. Conversely, the average post-DNA synthetic time, corresponding essentially to the duration of the prophase, is short and very constant in type B (4.5 hours), longer and variable in intermediate (6 hours) and AIV (8 hours) spermatogonia, and much longer and much more variable in AIII (11 hours), AII and AI (14 hours) spermatogonia. The premeiotic synthesis of DNA takes place in primary spermatocytes during the resting phase and terminates just before the visible onset of the meiotic prophase. Its average duration is 14 hours. No further synthesis of DNA takes place in later stages of spermatogenesis.

Animals↗
PubMed1961

Calendar of gametogenic development in the prepuberal male mouse.

The timing of the first meiotic cycle in the young male mouse was established by serial sacrifices and subsequent paraffin sectioning of testis and epididymis. Meiosis commences in mice 8 to 10 days old. The highest frequency of any one phase of meiosis was found at days 17 to 19, when 47 percent of the tubules were found to contain late pachytene.

Animals↗
PubMed1961

Gonadotropin test.

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17-Ketosteroids↗