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At least 19 recordsLinked to original sources
PubMed1980

[Granulomatous tumors of a pseudo-Hodgkin type of the thymus gland (thymus gland lymphogranulosarcomas)].

The group of thymic lymphogranulosarcomas are losing their pathologic individuality as autonomous thymic tumors with particular histological and special evolutive characters. Experience shows that a good number of alleged "pseudo-hodgkinian thymomas" have evoluted in the hodgkinian mode. From a total of 56 apparently autonomous thymic tumors operated on in the Department of Surgery A at this hospital, 9 thymic lymphogranulosarcomas have been identified. Our observations confirm that "pseudo-hodgkinian" tumors of the thymic lodge are rather Hodgkin's disease or a primitive-ganglion Hodgkin's disease localized in the thymic lodge. In practice, the discovery of granulomatous tissue in a thymic lodge tumor, even in the absence of typical Sternberg cells, requires a search for other localizations to determine the evolutive stage of the disease. Experience shows that partial or total surgical excision, followed by combined chemotherapy, exploratory laparotomy and radiotherapy, offer the best chances of long term survival at present.

Adult↗
PubMed1989

[Effect of altered hormonal balance in the mother-fetus system on body weight, the adrenal glands, thymus gland and peripheral blood leukocyte composition in the offspring].

Pregnant rats have been injected intramuscularly with hydrocortisone-acetate or desoxycorticosterone-acetate (DOCA) for the III or the II-III trimesters of pregnancy. In the last case the animals are given not only greater doses of the hormones, but during a longer period. By the end of the pregnancy the drug dose decreases. In mother-rats after hydrocortisone injections the adrenals mass increases; after DOCA the body mass increases, and that of the adrenals drops. In the offspring hydrocortisone produces decline of the thymus and adrenals mass, as well as neutrophilic leucocytosis, lympho-, eosino-++- and monocytopenia. Just the opposite, DOCA results in lympho- and monocytosis, in increasing morphofunctional activity of monocytes. Common effects in hormonal action is demonstrated as underdevelopment of the adrenals, in decreasing thymus mass, in development of neutrophilic leucocytosis and eosinopenia. With increasing doses and duration of prenatal injections of corticosteroids in rats the mass of the adrenals and thymus drops even greater, stimulating effect of the hormones on the neutrophilic granulocytopoiesis decreases.

Adrenal Glands↗
PubMed1977

A comparative study of iodine uptake by thyroid and thymus glands of male and female Sprague-Dawley rats of different ages.

The iodine concentrating ability of thyroid glands, thymus gland and skin in Sprague-Dawley rats was assessed by determining the tissue/blood radioiodide concentration ratios. Tissue/blood ratios are significantly affected by the age of the rats, however, thymus/blood radioiodide ratios never exceeded unity. The comparative uptake of 131I by thymus and thyroid tissue expressed as thymus/thyroid (%) for neonate animals was 10-16 times greater than those obtained for older rats. Moreover, the fraction of injected dose of radioiodide in thymus tissue never exceeded that of the thyroid or skin and paralleled the concentration of radio-activity in the blood. These results indicate that although neonate thymus tissue contains a significantly greater amount of radioactivity than the thymus of older rats, an active iodide concentration mechanism is not involved.

Age Factors↗
PubMed1999

Differentiation of fetal pig endocrine cells after allografting into the thymus gland.

BACKGROUND: The thymus of large animals, such as the pig, is thought to be an appropriate site for transplanting adult islets, which contain numerous beta cells, for the purpose of reversing diabetes. Whether fetal islet-like cell clusters (ICCs), which contain few beta cells, will develop at this site, so that adequate amounts of insulin can be produced, is unknown. METHODS: Between 15,000 and 40,000 ICCs were injected into the thymus gland of six juvenile immunosuppressed pigs, and the animals were killed up to 30 days later. The graft was then examined histologically and comparisons made with untransplanted ICCs and those grafted into the omentum of immunosuppressed pigs. RESULTS: At transplantation, the percentage of cells in the ICCs containing insulin, glucagon, somatostatin, or pancreatic polypeptide was 9+/-1%, 13+/-2%, 9+/-1%, and 3+/-1% respectively. Within 9-30 days of transplantation into the thymus, the percentage of all endocrine cells increased, insulin to 41+/-3%, glucagon to 43+/-6%, somatostatin to 26+/-4%, and pancreatic polypeptide to 9+/-3%. There was co-localization of more than one hormone in some cells. Omental grafts contained a similar percentage of insulin and glucagon-containing cells, but significantly fewer somatostatin and pancreatic polypeptide-containing cells. CONCLUSIONS: Endocrine cells from the fetal pig pancreas will differentiate when transplanted into the thymus gland of the pig, making this a suitable site for grafting ICCs to test their ability to normalize blood glucose levels of diabetic recipients.

Animals↗
PubMed1979

Functional relationship of macrophages and basophils to the thymus gland.

Human thymus epithelium, depleted of thymocytes and macrophages by means of organ culture, was used in chemotaxis experiments with peripheral blood cells. Such cultured thymus epithelium can attract specifically macrophages and basophils. T-lymphocytes were attracted only by short-term (8 day) cultured thymus tissue which still retains some of the original macrophage population. Thymic macrophages formed rosette structures with thymocytes. In other experiments 'activated' rabbit macrophages had the capability to destroy thymocytes, whether autochthonous or allogeneic. The possible role of macrophages and basophils in thymus function is discussed.

Animals↗
PubMed1988

Ultrastructure of the APUD-like cells of the frog thymus gland.

Within the thymus gland of the European common frog, Rana temporaria, cells with endocrine- like appearance have been found. At the ultrastructural level the most characteristic feature of their cytoplasm is the presence of secretory granules. Some cells possess irregular electron lucent granules with an eccentrically located dense core while others possess smaller electron dense granules. The cytoplasm contains also cisterns of rough endoplasmic reticulum, free ribosomes, and small mitochondria. The cells possess irregular nuclei with the pronounced nucleoli. These endocrine-like cells are connected by desmosomes with neighbouring non-granulated epithelial cells. Ultrastructural features of the cells described here resemble those seen in polypeptide hormone-secreting cells belonging to the family of cells of the APUD (Amine Precursor Uptake and Decarboxylation) series.

APUD Cells↗
PubMedDate not supplied

Tin in the thymus gland of dogs.

The thymus glands from four mixed breed dogs were analyzed to determine the water content, chloroform extractable fraction and residue. The thymi samples were assayed for tin and compared to the tin in the spleen and muscle tissue. The tin content in the thymus gland (29.4 ppm) was higher than the muscle (14.9 ppm) or spleen (12.8 ppm). The tin content in the lipid portion of the thymus was approximately four times greater than the non-chloroform extractable fraction (primarily protein).

Animals↗