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At least 19 recordsLinked to original sources
PubMed1997

Organ cultures of embryonic rat tongue support tongue and gustatory papilla morphogenesis in vitro without intact sensory ganglia.

Taste buds on the mammalian tongue are confined to the epithelium of three types of gustatory papillae: the fungiform, circumvallate, and foliate. The gustatory papillae are composed of an epithelium that covers a broad connective tissue core, with extensive innervation to taste bud and nongustatory epithelial locations. Although the temporal sequence of gustatory papilla development is known for several species, factors that regulate initiation, growth, and maintenance of the papillae are not understood. We tested the hypothesis that sensory innervation is required for the initial formation and early morphogenesis of fungiform papillae in a patterned array. An organ culture of the embryonic rat tongue was developed to provide an in vitro system for studying mechanisms involved in fungiform papilla morphogenesis in patterns on the anterior tongue. Tongues were dissected from embryos at 13 days of gestation (E13), a time when the tongue has not yet fully formed and gustatory papillae have not yet appeared, and at 14 days of gestation (E14), when the tongue is well formed and papillae make their initial morphological appearance. Dissected tongues were maintained at the gas/liquid interface in standard organ culture dishes, fed with DMEM/F12 plus 2% B-27 supplement and 1% fetal bovine serum. After 1, 2, 3, or 6 days in culture, tongues were processed for scanning electron or light microscopy, or immunocytochemistry. Tongues cultured from E13 or E14 underwent extensive morphogenesis and growth in vitro. Furthermore, fungiform papillae developed on these tongues on a culture day equivalent to E15 in vivo; that is, after 2 days for cultures begun at E13 and 1 day for those begun at E14. Because E15 is the characteristic time for gustatory papilla formation in the intact embryo, results demonstrate that the cultured tongues retain important temporal information related to papilla development. In addition, fungiform papillae formed in the tongue cultures in the stereotypic pattern of rows. The papillae were large structures with epithelial and mesenchymal cell integrity, and an intact epithelial basement membrane was indicated with laminin immunoreactivity. The cultures demonstrate that gustatory papilla morphogenesis can progress in the absence of an intact sensory innervation. To exclude a potential developmental role for autonomic ganglion cells that are located in the posterior rat tongue, cultures consisting of only the anterior half of E14 tongues were established. Fungiform papilla development progressed in half tongues in a manner directly comparable to whole tongue cultures. Therefore, robust, reproducible development of fungiform papillae in patterns is supported in rat tongue cultures from E13 or E14, without inclusion of intact sensory or major, posterior tongue autonomic ganglia. This is direct evidence that papillae will form and develop further in vitro without sensory ganglion support. The data also provide the first detailed account of in vitro development of the entire embryonic tongue.

Animals↗
PubMed2000

Functional anatomy of the hypoglossal innervated muscles of the rat tongue: a model for elongation and protrusion of the mammalian tongue.

This anatomical investigation in the rat was designed to illustrate the detailed organization of the tongue's muscles and their innervation in order to elucidate the actions of the muscles of the higher mammalian tongue and thereby clarify the protrusor subdivision of the hypoglossal-tongue complex. The hypoglossal innervated, extrinsic styloglossus, hyoglossus, and genioglossus and the intrinsic transversus, verticalis and longitudinalis linguae muscles were observed by microdissection and analysis of serial transverse-sections of the tongue. Sihler's staining technique was applied to whole rat tongues to demonstrate the hypoglossal nerve branching patterns. Dissections of the tongue demonstrate the angles at which the extrinsic muscles act on the base of the tongue. The Sihler stained hypoglossal nerves demonstrate branches to the styloglossus and hyoglossus emanating from its lateral division while branches to the genioglossus muscle exit from its medial division. The largest portions of both XIIth nerve divisions can be seen to enter the body of the tongue to innervate the intrinsic muscles. Transverse sections of the tongue demonstrate the organization of the intrinsic muscle fibers of the tongue. Longitudinal muscle fibers run along the entire circumference of the tongue. Alternating sheets of transverse lingual and vertical lingual muscles can be observed to insert into the circumference of the tongue. Most importantly in clarifying tongue protrusion, we demonstrate the transversus muscle fibers enveloping the most superior and inferior portions of the longitudinalis muscles. Longitudinal muscle fascicles are completely encircled and thus are likely to be compressed by transverse muscle fascicles resulting in elongation of the tongue. We discuss our findings in relation to biomechanical studies, that describe the tongue as a muscular hydrostat and thereby define the "elongation-protrusion apparatus" of the mammalian tongue. In so doing, we clarify the functional organization of the hypoglossal-tongue complex.

Animals↗
PubMed2003

Plasticity in corticomotor control of the human tongue musculature induced by tongue-task training.

Transcranial magnetic stimulation (TMS) has been used to assess characteristics of the corticomotor control of the jaw muscles, but less is known about the cortical control of the human tongue and its modification by training. The aim of the present study was to determine the effect of training humans in a novel tongue-protrusion task for 1 week on corticomotor excitability as assessed by changes in electromyographic activity elicited in the tongue musculature by TMS, and in the tongue cortical motor map revealed by TMS. Eleven healthy subjects participated. Stimulus-response curves were generated from the motor evoked potentials (MEPs) recorded in the tongue musculature and, from the first dorsal interosseos (FDI) muscle as a control, at three time periods: at baseline, immediately after the 1-week training period, and at 2-weeks follow-up. In addition, the corticomotor representations of the tongue and FDI muscles were mapped on a 1 x 1 cm scalp grid. The tongue-training task required each subject to protrude the tongue onto a force transducer placed in front of the subject, and consisted of a relax-protrude-hold-relax cycle lasting 12.5 s with 1 N as the target at the hold phase. The subjects repeated this task for 60 min every day for 1 week. All subjects reported moderate levels of fatigue in the tongue during the first training day; however, these subjective reports decreased during the week (ANOVA P<0.001), and the subjects showed a progressive increase in their ability to perform the task successfully ( P<0.001). The threshold for evoking MEPs by TMS in the tongue musculature was significantly decreased after the last training day compared with baseline and the 2-weeks follow-up ( P<0.001). The amplitude of the MEPs in the tongue musculature was significantly increased at higher intensities of TMS after the last training day but returned to baseline values at the 2-weeks follow-up (P = 0.005). No significant effect of the training on MEPs in the FDI was observed (P = 0.493). Analysis of the corticomotor topographic maps revealed a significant ( P<0.05) increase in excitability and, hence, the cortical area from which TMS could evoke MEPs in the tongue, although the center of gravity representation for the tongue or FDI muscles remained stable. The present findings suggest that a specific and reversible plasticity of the corticomotor excitability related to tongue muscle control can be induced when humans learn to perform successfully a novel tongue task.

Adult↗
PubMed1991

Accurate localization of organ representation areas of the tongue, using the Bi-Digital O-Ring Test: its clinical application, and re-evaluation of classical Oriental tongue diagnosis--Part I.

In spite of the importance of tongue diagnosis in Oriental Medicine, a very rough assignment of only a limited number of the major internal organs is known, and some of the assignments are not exactly the same, depending upon various schools of thought. In 1980, the author first developed a simple, quick, non-invasive, accurate method of localizing representation areas of internal organs, using the Bi-Digital O-Ring Test Molecular Identification Method based on the resonance phenomena between 2 identical substances or tissues, with a microscope slide of a specific internal organ as a reference control substance. The method was applied to the organ representation areas in the ears, hands, feet, cerebral cortex, and tongue. In this article for the first time detailed organ representation areas of the human tongue are being presented in comparison with currently known organ representation areas on the tongue. For convenience, the tongue can be divided into 3 parts: the anterior, the middle, and the posterior. On each side of the anterior part (1st part, area around the tip) of the tongue, the internal organs in the chest cavity are represented; from the mid-line to each side of the tip of the tongue, the oesophagus, thymus gland, lung (and trachea & bronchi), heart, and breast (over heart area) are represented. The middle (2nd) part of the tongue represents the digestive system, and the 3rd part represents the genito-urinary system. The 2nd part of the tongue represents the rectum, colon, cecum, appendix, small intestine, stomach, pancreas, liver, and gall bladder. The 2nd and 3rd parts of the tongue represent all the internal organs in the abdominal cavities and the genito-urinary area. The remaining one-third of the tongue, near the pharynx, is all related to the genito-urinary system with the exception of the spleen, which is located between the kidney and the adrenal gland representation areas. Within the triangular area formed by the sulcus terminalis, the anus is represented on both sides. Finally, at the peak of that triangle, i.e. the foramen cecum, the coccyx is represented. Extremities are represented at the sides of the tongue. The undersurface of the tongue starting from the tip of the tongue in the mid-line and going towards the root of the tongue along the frenulum in the mouth represents one kind of homunculus consisting of the neck, face, head, ears, upper & lower extremities and back of the body.(ABSTRACT TRUNCATED AT 400 WORDS)

Acupuncture Points↗
PubMed2001

Proposal of a new grading system for evaluation of tongue hemiatrophy as a late effect of brachytherapy for oral tongue cancer.

PURPOSE: To evaluate tongue hemiatrophy as a late effect of brachytherapy, a new grading system was designed and applied to patients who had received low dose rate (LDR) or high dose rate (HDR) brachytherapy for early tongue cancer. METHODS AND MATERIALS: Between December 1998 and April 1999, 49 patients who had received brachytherapy for early tongue cancer (T1/T2=22:27) at Osaka University Hospital were investigated. All patients had undergone either LDR or HDR brachytherapy with Ir-192 (LDR/HDR=30:19) between 1980 and 1998. Atrophic changes in their tongue were classified into four categories (G0-G3): G3, not able to protrude the tongue beyond incisors; G2, hemiatrophy is seen on the irradiated side in the resting position of the tongue; G1, deviation of the tip of the tongue to the irradiated side is seen when protruded; and G0, none of these signs. The relationship between tongue hemiatrophy and tumor factors, treatment factors, and patients' functional impairment was then investigated. The median time from treatment to assessment was 75 months (range 8-219 months). Volume index was defined as the number of needles that were implanted vertically into the tongue. RESULTS: Fourteen patients were classified as G0, 29 as G1, five as G2, and one as G3. None of the G0 patients showed any speech or swallowing dysfunction, pain or contracted feeling, or general dissatisfaction with post-treatment tongue status. There was a tendency for such problems to increase with the tongue hemiatrophy grade. The frequency of T2 and non-superficial type tumors also tended to increase with the tongue hemiatrophy grade. The volume index of the G2-3 hemiatrophy group was significantly larger than that of the G0-1 group (P=0.041). CONCLUSION: This new grading system makes evaluation of atrophic changes in the tongue after brachytherapy easy and effective.

Adult↗
PubMed1998

Functional reconstruction of the tongue and deglutition muscles following extensive resection of tongue cancer.

The authors describe their experience with functional restoration of tongue and deglutition muscles at the floor of the mouth after an extensive resection of tongue cancer. Five patients underwent immediate tongue reconstruction using a reinnervated rectus abdominis myocutaneous free flap in which the included tenth intercostal nerve was coapted to the remaining hypoglossal nerve. The rectus sheath strips attached on both cut ends of the muscle were used to create the firm tendinous insertions between the mandible and hyoid bone based on the anatomic findings of the extrinsic tongue and suprahyoid muscles. The postoperative course was uneventful in all patients. All patients presented with good tongue bulk without obvious atrophy. Three patients with subtotal glossectomy demonstrated good cooperative mobility of the reconstructed and remaining tongue and had solid or semisolid/soft diet. However, two patients with total glossectomy did not show satisfactory rehabilitation of the reconstructed tongue. Postoperative electromyographic assessment in two patients showed good functional recovery of the grafted muscle. The cine-magnetic resonance imaging deglutition study in one patient with 80-percent tongue resection demonstrated sufficient elevation of the dorsal base of the reconstructed tongue, contraction of the reconstructed deglutition muscles, complete glossopalatal closure, and elevation of the hyoid bone and larynx during the deglutition. This reconstructive technique is strongly recommended for the patients who have undergone subtotal glossectomy to provide physiological functional recovery of the reconstructed tongue synchronizing with the remaining tongue.

Adult↗
PubMed1983

Squamous cell carcinoma of the tongue: a comparison of the anterior two thirds of the tongue with its base.

A retrospective analysis of 176 patients with squamous cell carcinoma of the tongue has been reported. The tongue base and mobile tongue, believed to behave as two clinically distinct anatomic areas, have been compared and contrasted. Women comprised 25 percent of the patients with tumors of the base of the tongue and 45 percent of those with mobile tongue lesions, an increase over previous reports for both locations. The majority of patients with squamous cell carcinoma of the tongue base (77 percent) presented with advanced (stage III or IV) lesions at time of initial clinical and diagnostic staging, compared with only 33 percent of those with cancer of the mobile tongue. There was no significant difference in survival between the two locations when survival rates were compared stage by stage. The decreased overall survival frequently reported for patients with squamous cell carcinoma of the tongue base compared with the survival for patients with tumors of the mobile tongue may be due to the disproportionately high number of patients with cancer of the tongue base who present with advanced disease. Survival rates have not significantly improved when compared with other retrospective series reported in the past 40 years. We strongly urge the development of intercenter, multidisciplinary, cooperative, prospective, protocols to assess combinations of currently accepted therapeutic modalities in the hope of improving treatment of this devastating disease.

Adult↗
PubMed1990

[Relation of pale tongue, purple tongue and TXA2-PGI2 regulation system].

This paper analysed the relationship between pale tongue, purplish tongue and TXB2, 6-keto-PGF1 alpha levels in plasma of 70 cases with coronary heart disease (CHD) and 45 normal subjects. The results showed the following characteristics: The pale tongue group (217.76 +/- 30.5 pg/ml) showed no significant difference in TXB2 level compared with the normal group (164.49 +/- 10.85 pg/ml, P greater than 0.05), while both showed significant difference compared with the purplish tongue group (360.1 +/- 31.3 pg/ml) and that with purple spots (485.07 +/- 106.1 pg/ml, P less than 0.01). The pale tongue group (179.29 +/- 9.08 pg/ml) showed a significant difference in 6-keto-PGF1 alpha level compared with the normal group (244 +/- 19.31 pg/ml, P less than 0.01), but it showed no significant difference compared with the purplish tongue group (185.08 +/- 17.07 pg/ml) and that with purple spots (229.3 +/- 33.2 pg/ml, P greater than 0.05). The comparison between the groups of purplish tongue and that with purple spots and the normal group showed no significant difference (P greater than 0.05). The pale tongue group (1.33 +/- 0.18) showed a marked difference in TXB2/6-keto-PGF1 alpha ratio compared with the normal group (0.72 +/- 0.04, P less than 0.01), the purplish tongue group (2.12 +/- 0.22, P less than 0.01) and that with purple spots (2.25 +/- 0.55, P less than 0.05). The purplish tongue group and that with purple spots showed significant difference compared with the normal group (P less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)

6-Ketoprostaglandin F1 alpha↗
PubMed1998

Articulatory function and tongue mobility after surgery followed by radiotherapy for tongue and floor of the mouth cancer patients.

The aim of this study was to determine which of the following factors--size of the post-excisional defect, site of the defect and type of reconstruction--influence tongue mobility and articulation disorders after treatment for cancer of the tongue and floor of the mouth. A total of 60 patients, who had been evaluated at least 6 months after surgery followed by radiotherapy (60 Gy in 30 fractions), were evaluated. According to the size of the post-excisional defect patients were divided into two groups: (1) defect less than 5 cm (35); (2) defect more than 5 cm (25). Based on the localisation of the defect patients were also divided into two groups: (1) anterior tongue and/or floor of the mouth (30); (2) lateral tongue and/or floor of the mouth (25) and tongue base (5). According to the type of reconstruction patients were divided into three groups: partly reconstructed (18); reconstructed with locally available tissue--local flaps (27); and with pectoralis major myocutaneous (PMMC) flaps (15). Articulation proficiency was assessed through Articulation Test and tongue mobility through Tongue Mobility Test. According to results of this study, type of reconstruction followed by size of post-excisional defect seemed to be the most influential factor in tongue mobility and articulation disorders after the tongue and floor of the mouth cancer treatment. Site of the defect has no influence.

Adult↗
PubMed1994

Determination of sagittal tongue shape from the positions of points on the tongue surface.

This paper describes a method for determining the shape of the midsagittal tongue contour from the positions of points on the tongue surface. The positions of the points and the tongue shape were measured simultaneously by using an alternating magnetic field device and an ultrasonic B-mode scanner for continuous speech utterances. A comparison between the magnetic and the ultrasonic data revealed that the average measurement difference between the two types of data was 1.16 mm. The shape of the tongue contour was then represented by multivariable linear regression of the magnetically determined positions. The results of the regression analysis showed that the tongue contour was estimated, from four positions on the tongue, with an average estimation error of 1.24 mm. This estimation error could be reduced to 0.84 mm when there was no measurement error between the magnetic and the ultrasonic data, and it was further reduced to 0.43 mm when the receiver coils of the magnetic device were positioned optimally on the tongue. It was also shown that the number of data frames for calculating the regression coefficients could be reduced, while maintaining the estimation accuracy, by appropriately selecting data frames. Finally, the tongue shape was estimated successfully for several phonemes from the magnetically determined positions, thus demonstrating the usefulness of this method for observing the articulatory configuration of the tongue.

Form Perception↗
PubMed2004

[Modification for primary tongue reconstruction with free forearm flap after radical operation of tongue carcinoma].

BACKGROUND & OBJECTIVE: Radical operation of tongue carcinoma causes hemi-tongue defective, which seriously affected the quality of life in these patients. The primary tongue reconstruction guaranteed the healing of the surgical incision at early stage. This may help to recover swallowing and speaking of the patients. However, the vascular crisis happened in the free flap proved to be an obstacle to the extensive application in the tongue reconstruction. This paper illustrated some modifications in the application of the free forearm flap, which may ensure the success in operation. METHODS: Some methods like skin flap design, preparation and vascular anastomosis were modified in the application among the 32 tongue carcinoma patients. RESULTS: The surgical incisions of the oral cavity and neck healed up, with no salivary fistula, chylorrhea, submandibular fistula, infection and other complications. After the operations, 6 flaps developed vascular crisis, and 5 flaps were successfully salvaged, meanwhile, one case failed, which resulted in the flap abandonment. The total successful transplantation rate reached 96.9%. The reconstructed tongue recovered, and the speaking as well as swallowing functions re-obtained. CONCLUSION: The modified methods of tongue reconstruction with free forearm flap improve the clinical effects of reconstructed tongue.

Adult↗