[Principles and clinical aspects of autologous tooth transplantation (tooth transposition)].
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Tooth transplantations provide the option of replacing lost or missing teeth in a biological fashion. On account of their high success rates and primarily in Scandinavian countries, they are a popular alternative to orthodontic or prosthetic treatment--particularly in case of children or young people losing teeth in accidents. Success of the treatment is ensured by corresponding diagnosis and good preoperative planning. Tissue-conserving transplant collection and the corresponding conditioning of the transplant bed are of decisive importance for the regeneration of the pulp and the periodontium. The success of the therapy is also influenced by the type and duration of splinting. Depending on the surgical technique and the transplanted tooth, the success rates are between 78% and 96%. The success criteria of a transplantation are defined clinically and radiologically. The diagnosis for transplantation is made from an orthodontic, endodontic, traumatologic, periodontologic and cardiologic perspective. The present article provides an overview of literature and shows current plantation techniques.
The major causes of post-transplantation tooth loss following tooth replacement after avulsion (exarticulation) and surgical replacement of impacted maxillary canines (auto-transplantation) are inflammatory root resorption and replacement resorption (ankylosis). This paper attempts to outline the treatment and management of replanted teeth using the current philosophies of splinting, endodontic therapy and the use of calcium hydroxide in the re-attachment of the periodontal ligament (PDL). Clinical research during the past 20 years has provided sufficient information for the development and establishment of a rational and effective program of treatment.
Allogeneic tooth transplantation was evaluated as a functional and aesthetic treatment for dental fracture in the dog. Of 7 dogs that received tooth transplants, 5 were research animals and 2 were clinical patients. Canine teeth were transplanted immediately after extraction in the research dogs. Endodontic therapy had been performed on the affected canine tooth of one clinical patient. The other clinical patient had bilateral maxillary canine fractures 2 months earlier. One of the research dog transplants failed at 3 weeks as a result of improper surgical technique. Four of the research dogs had a solid implant for 18 months, after which time the dogs were euthanatized serially. All transplanted teeth were anchored firmly into the alveoli, but were nonviable. Root resorption, with bone replacement, was first noticed at 24 months. The transplanted tooth in the first clinical patient remained functional for 3 months, after which time the tooth was fractured. The right canine transplant in the second clinical patient failed by 3 months, probably because of preexisting periapical inflammation. The left transplanted tooth remains stable at 38 months. It was concluded that allogeneic tooth transplantation may have merit as a rapid and inexpensive method for replacement of fractured teeth in the dog. Function is compromised gradually as a result of root resorption and ankylosis, with tooth fracture likely to occur after 2 years.
Tooth transplantation between preimmunized unrelated mismatched animals appears to induce the same immunologic problems that appear in the grafting of other organs. Such transplants showed more inflammatory root resorption and ankylosis and less reattachment of periodontal ligaments than did allografts between compatible animals. It appears that transferring the teeth to the similar side, suturing the gingival soft tissue around the teeth, splinting the transplanted teeth, and antibiotic therapy improve results by minimizing the effects of surgical procedures and trauma. Surgical trauma is confirmed as an important factor, along with immunogenetic differences between donor and recipient, in determining the outcome of tooth transplantation.
If tooth transplantation is to succeed, it is crucial to preserve the vitality of the cells on the root surface of the tooth transplant. Insufficient postoperative nutrition to the cells on the root surface of the tooth transplant was thought to contribute to their devitalization of these cells. Impaired nutrition may be a result of poor contact between the recipient bed and the root surface of the transplanted tooth, and development of an interposed blood clot. To improve postoperative nutrition to the root surface cells, teeth were transplanted to the recipient beds in which the tissues were regenerated during a 14 day period, i.e., using the two-stage transplantation technique. In a clinical study of this technique, a total of 95 autogenous teeth with fully developed roots were transplanted in 84 patients, and examined both clinically and radiographically for up to 13 years after the transplantation. In a dog model, a comparative experimental study was made between teeth transplanted to beds left to heal for 5 days and teeth transplanted to beds prepared immediately before the transplantation. The clinical study showed a low prevalence of tooth graft loss and root resorption even when infection of the root canal occurred. Periodontal attachment loss of less than 3 mm was found in 97% of 6 defined surfaces around the transplanted teeth. Transplanted teeth which were later extracted were often hypermobile, and signalled pain when provoked with heavy loading. Excessive extraction trauma, fixation failure, and excessive plaque accumulation after transplantation were all shown to be detrimental to tooth transplant. Transplanted teeth were used as abutments for fixed partial dentures and provided the necessary dental support for crowns and bridges even in patients with atrophic alveolar bone. The experimental histological study showed no differences between test and control teeth in terms of the prevalence of root resorption, which was suspected to be caused by traumatic injuries to the roots during extraction and non-rigid fixation of the transplanted teeth.
Allogeneic orthotopic tooth transplants in the rabbit appear to stimulate transplantation immunity reactions comparable to those encountered with the transplantation of other organs. Intact untreated teeth were shown to be as quantitatively immunogenic as skin grafts between unrelated animals. Histocompatibility matching of donor and recipient and removal of pulpal tissues were demonstrated to be effective means of ameliorating the immune response to allogeneic orthotopic tooth transplants in the rabbit.
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A therapeutic alternative in treating the loss of single teeth, the treatment with implant-borne crowns or autologue transplantation of teeth is gaining increasing importance in clinical dentistry. Both surgical techniques were demonstrated, and the authors tried to differentiate the ranges of indications for endosseous implants and autologue transplantation of teeth.
A method was devised, from a pilot study, for transplanting a root-treated tooth with an intact periodontium into a newly prepared socket to assess whether the prognosis for transplantation procedures could be improved. Five male vervet monkeys were used for the definitive study. The mandibular central incisors were extracted from each monkey and the sockets were allowed to heal for 5 weeks. Thereafter a window of gingiva overlying each of these healed receptor sites was removed and the sockets were prepared with tapered burs. The distal root of the mandibular second molar was used as the transplant tooth and the distal root of the first molar as the control tooth. The transplant tooth was removed, together with surrounding alveolar bone which was then trimmed to a thickness of approximately 1 mm. The control tooth was extracted with root forceps. After transplantation, the teeth were splinted to the adjacent incisors for 3 weeks. After 8 weeks the healing process was examined histologically, both qualitatively and quantitatively. Replacement resorption (ankylosis) was not observed. Student's t test for paired samples revealed that the incidence of secondary cementum formation was significantly greater on the control teeth. The minimization of trauma may be the reason ankylosis did not occur.
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A patient developed infective endocarditis caused by Campylobacter fetus. He gave a history of recent dental extraction and allogeneic tooth transplantation. He was treated with various antibodies to which the organism was said to be sensitive, but it was not until the transplanted tooth was removed that he started to improve. The mode of infection was thought to be blood borne through the open tooth socket from the raw chicken that he ate regularly.
This paper describes a case of autogenous tooth transplantation. An external inflammatory root resorption developed in a 30-year-old female patient and was successfully treated with the placement of calcium hydroxide-based intracanal dressings. Autotransplantation of tooth 32 into the extraction socket of tooth 30 was carried out with no intraoperative complications and uneventful postoperative course. However, the patient did not appear on the 14th postoperative day to initiate endodontic therapy of the transplanted tooth. She did not return for 3 months, at which time the clinical and periapical radiographic examinations revealed the presence of external inflammatory root resorption. Endodontic treatment was initiated immediately. Root canals were prepared and filled with a calcium hydroxide-based intracanal dressing (Calen paste), changed every 21 days during a 6-month period, and were thereafter obturated with Sealapex calcium hydroxide-based sealer and gutta-percha points. After 2 years of follow-up, the transplanted tooth was symptom free with no exacerbated sensibility to percussion, normal mobility, occlusion, and masticatory function. Probing revealed no periodontal pockets or other pathological signs. Radiographic examination showed the periradicular area with normal appearance, completely healed resorption areas, and presence of an intact lamina dura.
In the first part of the presentation, the content of orthodontics has been briefly explained by means of some clinical cases. The main part of the presentation consisted of discussing patient treatment by means of autogenous tooth transplantation with special emphasis on its indications and contra-indications. When a tooth transplantation is carried out properly, a success percentage of 90%, even forty years after treatment, can be expected. This high percentage has been reported in a recent study. The success of tooth transplantation is mainly due to the timing of the transplantation and the non-traumatic handling during surgery. According to the literature, the ideal moment for tooth transplantation is when half to three quarters of the root has been formed. One of the indications for tooth transplantation is the transplantation of a tooth in the cleft of a cleft palate patient. Two cleft palate patients have been presented in which tooth transplantation was carried out after bone grafting in the alveolar cleft. Finally some findings of a recent study, carried out at our department, dealing with cryopreservation of teeth before transplantation, has been presented. According to the findings of this study, cryopreservation, after removal of the pulp tissue does not inhibit the normal ingrowth of new pulp tissue after transplantation.
Autogenous tooth transplantation, or autotransplantation, is the surgical movement of a tooth from one location in the mouth to another in the same individual. Once thought to be experimental, autotransplantation has achieved high success rates and is an excellent option for tooth replacement. Although the indications for autotransplantation are narrow, careful patient selection coupled with an appropriate technique can lead to exceptional esthetic and functional results. One advantage of this procedure is that placement of an implant-supported prosthesis or other form of prosthetic tooth replacement is not needed. This article highlights the indications for autogenous tooth transplantation using 3 case reports as examples. A review of the recommended surgical technique as well as success rates are also discussed.
Autogenous tooth transplantation is an alternative treatment for preserving continuity of the dental arch following early loss of teeth. The prognosis of transplants determines the indication as compared with other methods of space closure. Transplanted buds of upper premolars as well as of lower third molars continue their root growth. The clinical and roentgenological analysis of 81 autogenously transplanted upper canines, following different operative procedures, indicates, that 50% of the transplants remain in situ for five years and only 25% remain in situ longer than six years. The statistical chances of survival of vitally transplanted, apicoectomied teeth are more favourable. Short-term prognosis is determined by inflammatory bone and/or tooth resorption due to odontogenic infection or occlusal trauma. Long-time prognosis is determined by different forms of tooth resorption. Regular radiographic examination as reveal early odontogenic infections which can then be treated endodontically. The doubtful prognosis necessitates strict indications.