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Results for “TREMOR/experimental”

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At least 19 recordsLinked to original sources
PubMed1959

The analysis of drug-induced tremor in mice.

An improved method of recording tremor in mice has been developed using a gramophone pick-up and a cathode ray oscillograph. Permanent records are made on 35 mm. film from which it is possible to determine qualitative differences in the tremor caused by various drugs. In addition, the severity of the tremor may be estimated quantitatively by a tremor index. The rate and variations in the rhythm and amplitude and in the tremor index have been determined for Tremorine (1,4-dipyrrolidin-1'-ylbut-2-yne), harmine, harmaline, 3-amino-1,1,3-triphenylpropan-1-ol and lysergic acid diethylamide. The incidence of side effects has also been noted.

Animals↗
PubMed1959

Antagonism of the effects of tremorine by tropine derivatives.

Methods of testing new drugs for anti-Parkinson activity are briefly reviewed. The production in animals of Parkinson-like effects by Tremorine (1,4-dipyrrolidin-1'-ylbut-2-yne), and the inhibition of these effects in mice by a number of tropine derivatives, are described. No correlation was found between the activity against tremor and the anticholinergic, antihistaminic or local anaesthetic properties of the compounds.

Animals↗