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At least 19 recordsLinked to original sources
PubMed1982

Immunofluorescence and Treponema infection: a method using immunofluorescence to study rabbit testicular tissue infected with T pallidum and T pertenue.

We compared immunofluorescent staining of rabbit testicular tissue infected with Treponema pallidum or T pertenue, and fixed in Bouin's fixative, 95% cold ethyl alcohol with 1% glacial acetic acid, or routine 10% buffered formalin solution. The fixative of choice clearly was Bouin's. Although we studied only rabbit tissue, we assume that these fixatives will work well in human biopsy or autopsy material when identification of pathogenic Treponema is needed.

Animals↗
PubMed1975

Effect macrophage activation on infection with Treponema pallidum.

Infection of rabbits with Treponema pallidum induces nonspecific acquired cellular resistance (ACR) to Listeria monocytogenes. This resistance can be adoptively transferred using thymus-dependent lymphocytes. Since infections that induce ACR are usually brought under control by cellular mechanisms, we sought to determine whether induction of ACR in rabbits stimulates resistance to challenge with T. pallidum. When BCG-infected rabbits which suppressed the growth of Listeria were challenged intravenously with T. pallidum, lesions appeared at the same time and progressed in a fashion similar to that in non-BCG-infected controls. There was a tendency for syphilitic lesions to disseminate more widely in BCG-infected animals and for the lesions to necrose more rapidly in controls. T. pallidum may resist phagocytosis by macrophages, as has been suggested previously, or macrophages may fail to be activated locally in the dermis. Although syphilitic infeciton appears to stimulate ACR, activation of the macrophages may not contribute significantly to the ability of the host to suppress T. pallidum.

Animals↗
PubMed1984

Experimental Treponema hyodysenteriae infection of mice.

Factors such as strain, fasting period, sex and age of the animals, and challenge dose were examined for their effects on the development of infection with Treponema hyodysenteriae in mice. Among mice tested, Ta:CF#1 mice were the most susceptible to the infection. Ta:CF#1 mice developed gross cecal lesions by a single oral dose ranging 10(2)-10(7) colony-forming units of T. hyodysenteriae without preinoculation fast. Oral challenge with 10(7) colony-forming units of the treponeme resulted in the development of gross lesions in all the mice at day 10. The number of T. hyodysenteriae in the feces and cecum of the mice reached the highest level at day 7 and 10, respectively; the levels lasted until day 21, the termination of the experiment. Macroscopic, microscopic and scanning electron microscopic findings of the lesions were similar to those of swine dysentery. These studies indicate that the Ta:CF#1 mice may be used as an excellent in vivo model system for swine dysentery.

Animals↗